Search results

Pedagogická činnost

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Postdoctoral Researcher / Junior Researcher

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Postdoctoral Researcher / Junior ResearcherScientific department: Department of Plant Developmental Genetics Project: TowArds Next GENeration Crops (OP JAK), CZ.02.01.01/00/22_008/0004581 Size of workload: 1,0Length of employment: until June 30, 2028 Minimum educational attainment: Completed Ph.D. studies in the field of molecular biology, genetics, genomics, or ...

E-mail

E-mailVelikost mailuCelková velikost příchozího mailu může být maximálně 13 MB, včetně zakódovaných příloh. Maximální velikost příloh před zakódováním je tedy cca 9 MB. Větší e-maily jsou mailserverem odmítány.Filtrace pošty na serverech BFÚ AV ČR v BrněZ důvodů rozsáhlého šíření zavirovaných a nevyž&...

Doktorand/ka

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History of the IBP

History of the IBP Research focused on the investigation of physical properties of biological systems has an old tradition in Brno. The history of biophysics in the former Czechoslovak Republic is closely connected with two men who worked at Masaryk University in the early 1930s, Ferdinand Herčík and Vilém Laufberger. While Professor Laufberger moved his activities to Charles University in Prague in 1935, Ferdinand Herčík remained in Brno. Professor Herčík's scientific interests ranged fr...

Collaborations

Collaborations International Prof. Bernhard Spingler – University of Zurich, Switzerland Dr. Janos Sagi – Rimstone labs, USA National Prof. Radovan Fiala – Faculty of Science, Masaryk University, Brno Prof. Libuše Trnková – Faculty of Science, Masaryk University, Brno Assoc. prof. Lukáš Trantírek – Central European Institute of Technology (CEITEC), Brno Assoc. prof. Peter Mojzeš – Faculty of Mathematics and Physics, Charles University, Praha Prof. Jan Vacek – Department of Me...

Genetický internet a GMO

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Projects

  Projects solved by the CIT:2016 vmware upgradeThe vmware virtualization infrastructure was upgraded from 5.x to 6.x including new hardware for ESXi servers.2015 WEB serverThere was installed a new web server and web pages of the IBP were transferred to it.2015 MAILThere was installed a new POP/IMAP server and mailboxes were transferred from MBOX to MAILDIR format. This new mailbox format enables to backup mailboxes of higher capacity.2015 Disk array for vmwareThe new disk array for s...

Vědecký inkubátor

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Group of DNA replication & genome stability

DNA replication & genome stability   Our lab is deeply interested in exploring the fundamental molecular mechanisms that ensure flawless DNA replication and maintain genome stability over multiple generations of dividing cells.   RESEARCH INTEREST: The development of the human body begins with a single cell, a fertilized egg, which divides about ten trillion times to form an adult. During each cell division, the entire genome is duplicated with ultra-high accuracy and subsequently inherit...

Ongoing grant projects

Fascinating Structure of Holliday Junction: The Crux of DNA Biophysics Studied by Molecular Dynamics Simulations Project Number: 25-16134S Principal Investigator: RNDr. Miroslav Krepl, Ph.D. Funding Agency: Czech Science Foundation (GA ČR) Project Duration: 2025–2027 Institution: Institute of Biophysics of the Czech Academy of Sciences, v.v.i. Project Description The project focuses on a detailed investigation of the so-called Holliday Junction (HJ), a unique four-stranded DNA structure that ...

Actions 2024-2026

Actions Action 1.  Support of mobility, particularly, for PhD students employed at the IBP – a career improvement. A new institutional regulation will be established Action 2.  Evaluation of departments (bibliometric analyses of scientific results). Evaluation of departments and their leader is performed using two independent systems Action 3.  The best PhD student award, Application Award, Internal cooperation Award, Methodology Award, and The scientific paper of the year Actio...

K postneodarwinismu

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Doktorand/ka

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Pedagogická činnost

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Research

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Research Results

 The List of the Most Important Scientific Results of the Institution obtained in the Period 2005–2009Department 1     Molecular Biophysics and Pharmacology (DMBP)[1] DNA-protein cross-links by antitumor cisplatin(a) K. Chvalova, V. Brabec, and J. Kasparkova:  Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin. Nucleic Acids Research, 35,1812-1821, 2007, IBP: all authors. IF 6.9; 15 citations on WOS(b)100% contribution by Brno laborat...

International Cooperation

 Importance of the international cooperationFundamentally, basic research is an international activity. International cooperation therefore plays a very significant role in research conducted at the Institute of Biophysics of the Czech Academy of Sciences (IBP). This kind of cooperation is important to all departments and is also a prerequisite for the independent existence of a department within the Institute. As can be seen from the attached list, a significant proportion of papers produc...

National Cooperation

National CooperationIn Czech only odděleníidentifikační kód projektuposkytovatelnázev projektuřešení projektuDBCMOIBS5004107AV ČRAplikace biofyzikálních metod v biotechnologické a klinické praxi20012005DBCMOIBS5004355AV ČRMožnosti elektrochemických metod v genomice, základy vývoje biosenzorů DNA20032005DC1QS500040507AV ČRTukové složky výživy - modulace jejich účinků a ...

Vědecký inkubátor

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Implementation/Embedding the HRS4R process 2024-2026

Implementation/Embedding the HRS4R process 2024-2026 General overview of the implementation process in 2022-2023:       The implementation process started with a great interest from both our Working Group, Screening Committee and Director of the Institute. The employees of the Institute of Biophysics had a good understanding and appreciation of the HRS4R activity keeping in mind the Gap Analysis and significance of the HRS4R process.        Our aim to consolidate the position of a nation...

Sedlackova lab news

NEW PAPER: PAF15-PCNA exhaustion governs the strand-specific control of DNA replication We are delighted to share that our lab contributed to a study recently published in Nature, which uncovers how human cells sense the limits of DNA replication—a fundamental mechanism with important implications for understanding replication stress in cancer. This exciting work reveals how cells monitor and protect genome duplication when replication demand becomes excessive, opening new perspectives on ho...

Research Reports

Research reportsResearch Report 2012-2014 (in the PDF format)Research Report 2011 (in the PDF format)Research Report 2010 (in the PDF format)Research Report 2009 (in the PDF format)Research Report 2008 (in the PDF format)Research Report 2007 (in the PDF format)Research Report 2006 (in the PDF format)Research Report 2005 (in the PDF format)Research Report 2004 (in the PDF format)Research Report 2003 (in the PDF format)Research Report&nbs...

Citation frequencies of the Institute in comparison to some advanced countries

The frequencies of highly cited publications of the Institute are similar or higher as compared to the average of some advanced countriesThe number of publications cited with some frequency (e.g. between 10-20 citations, 20-30 citations, etc.) divided by the total number of publications represents the probability density of the occurrence of any publication at given interval. This quantity in dependence on the number of citations provides a citation spectrum. Owing to its dependence on time, the...

Citation frequencies in biophysics for different countries

We are sorry, the results are so far presented only in the Czech language....

Research Profile

Research Profile IBP is engaged in basic research in the field of biophysics,more precisely, in the research of the structure, function and dynamics of biological systems (biomolecules, cell components, cells and cell populations) using a broad spectrum of methods (molecular biology, biochemistry, biophysics, bioinformatics, etc.). IBP contributes to increasing the level of knowledge and education, to the development of biotechnologies and to the transfer of reseach results to practical applicat...

Viry, pavučina života a lehký vánek bytí

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Pedagogická činnost

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Job offer

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Pedagogická činnost

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Meet Dr. Klara Janjic—a guest researcher & lecturer in the Sedlackova lab

Meet Dr. Klara Janjic—a guest researcher & lecturer in the Sedlackova lab Klara Janjic started her journey as a scientist with a Bachelor program in “Biomedicine and Biotechnology” at the University of Veterinary Medicine in Vienna, Austria. Afterward, she continued to study the Master's program “Molecular Medicine” at the University of Vienna, for which she performed her master's thesis at the University Clinic of Dentistry, Medical University of Vienna. In 2020, she completed her...

Stixova et al., 2024 Heliyon

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Doktorand/ka

Institute of Biophysics of the Czech Academy of Sciences Královopolská 135, 612 65 Brno, Czech Republic offers a position PhD student (R1) (part-time with 0.3 workload – 12 h/week) at the Department Biophysical Chemistry and Molecular Oncology project GAČR 22-21903S, Local DNA structures and their role in mutant p53 protein function in human tumours Requirements: Completed university education in biochemistry or biotechnology English at B2 level Experience working with electrophoretic sepa...

Člověk jako ekosystém

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Cumulative IF and AIS

In the following tables the cummulative impact factors and article influence scores for the period 2000-2010 and for the departments of our Institute are shown. The first two tables involve publications in which the corresponding author is affiliated with our Institute (own publications). The following two tables involve publications prepared in the frame of collaboration in which the corresponding author is affiliated to the collaborating institution. The list of publications has been generated...

Research Equipment

Department of Molecular Biophysics and PharmacologyUV/VIS Raman Spectrophotometer (Jobin-Yvon, Model T64000).Microcalorimeters Microcal (differential scanning and isothermal titration calorimeters)FUJIFILM bio-imaging analyzer (AIDA image analyzer software).Varian AA240Z Zeeman atomic absorption spectrometer equipped with a GTA 120 graphite tube atomizer.LZC-4V illuminator (photoreactor) (Luzchem, Canada) with temperature controller.This instrumentation belongs to a basic equipment of the Depart...

DNA, okno do minulosti i budoucnosti

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Pedagogická činnost

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Little Academic Gallery

http://mag.ibp.cz...

XXXVI. Moderní elektrochemické metody

XXXVI. Moderní elektrochemické metodyPozvánkaVzor příspěvku ve sborníku...

Koncepční záměr pracoviště

https://www.ibp.cz/cs/o-instituci/poslani-instituce/poslani-a-koncepce-biofyzikalniho-ustavu-av-cr...

Alumni

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Seeing is believing: Visualization of DNA replication machinery in living cells

Seeing is believing: Visualization of DNA replication machinery in living cells DNA replication is a fundamental process in every living organism. Precise regulation of genome duplication is absolutely critical for the fitness and survival of the organism as errors in DNA replication can lead to genome instability and the development of serious diseases such as cancer. Decades of beautiful work have provided new insights into the assembly, activation, and function of the replication fork, a basi...

Strategie AV21 - Udržitelná produkce a spotřeba potravin - Potraviny pro budoucnost

https://www.potravinyav21.cz/...

Research news

/getfile/?mode=readfile&path=/cms/Departments/DME/newres.pdf...

Hledání kódu lidství

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Pedagogická činnost

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Research profile

Research profile 1. Genetics of allopolyploid nucleus Polyploidy, in which the entire chromosome complement multiplies (3x, 4x, etc.), is widespread in angiosperms, indeed up to 80% of species may be polyploids and sequence data suggest that even apparently diploid species are, in fact, palaeopolyploids. When polyploidy occurs after interspecific hybridisation the process is called allopolyploidy. Allopolyploidy restores fertility to newly formed hybrids, a driving force behind sympatric speciat...

Research news

/getfile/?mode=readfile&path=/cms/Departments/DMBP/selected_results.pdf...

2015 - Struktura a funkce buňky v normě a patologii

Struktura a funkce buňky v normě a patologiiProgram...

HR AWARD

HR AWARD The Institute of Biophysics of the Czech Academy of Sciences (IBP) acquired the Human Resources Excellence in Research Award (HR AWARD) The Institute of Biophysics of the Czech Academy of Sciences (IBP) was founded in the year 1955 and became an important part of the research infrastructure in Czechoslovakia and later also in the Czech Republic as a part of the main scientific extracurricular research institution, the Czech Academy of Sciences. Scientists work here as researchers in man...

Key Research Worker

Management of Institute of Biophysics of the CAS, v. v. i., Královopolská 135, 612 65 Brno advertises postdoctoral position  “Key Research Worker” at the project reg. no. CZ.02.1.01/0.0/0.0/15_003/0000477 Structural gymnastics of nucleic acids: from molecular principles through biological functions to therapeutic targets. Support of integrated research team (SYMBIT) financed from the European Regional Development Fund   Description The Institute of Biophysics (https://www.ibp.cz) of th...

Projects

Ongoing projectsHoward Hughes Medical Institute (USA), HHMI, INTNL 55005613Platinum and ruthenium compounds. From DNA damage to cancer chemotherapyPrincipal investigator: J. Kašpárková, 2006 - 2010MŠMT.Center of Basic Research, ME, LC06030Biomolecular CenterCoprincipal investigator: V. Brabec, 2006 - 2011AV ČR, Program Nanotechnology for Society, KAN200200651Nanoparticle and supramolecular systems for targeted transport of therapeutic drugs,Coprincipal investigator: ...

Gallery

Gallery...

Research news

/getfile/?mode=readfile&path=/cms/Departments/DMCC/Research_news.pdf...

Postdoctoral fellow - bioinformatician

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Postdoctoral fellow - bioinformaticianScientific department: Cell Biology and Radiobiology (Assoc. Prof. Falk)Project: GAČR 23-04769 Telomere biology of Trypanosomatids: contrasting features point to diverse  strategiesGAČR 23-06643S Disposition, distribution, and processing of DNA lesions in the genome of Arabidopsis thaliana plants defective in DNA repair and...

Research news

/getfile/?mode=readfile&path=/cms/Departments/DBCMO/newres.pdf...

Copenhagen August 2008

Copenhagen August 2008...

2012 - International Workshop on Advanced Confocal Microscopy and Living Cell Studies

http://cellbiol.ibp.cz/novinka/2...

Projects

Granted projectsInteractions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy. GA AS CR IAA500040701Principal investigator: M. Fojta, 2007-2010Construction of novel functional nucleic acids for applications in chemical biology, catalysis and self assembly. GA CR 203/09/0317Principal investigator: M. Fojta, 2009-2013DNA labeling with redox markers for electrochemical sensing. Applications in analysis of nukleotide sequences and ...

Teaching

Overview of the teaching activities Lecturer University Subject title Jiří Šponer   Masarykova universita, Brno Struktura a dynamika nukleovych kyselin Molekulove interakce a jejich uloha v chemii a biologii Jiří Šponer Univerzita Palackého v Olomouci Structure and dynamics of nucleic acids  ...

Research Centre

Centre of Biophysical Chemistry, Bioelectrochemistry and BioanalysisNew Tools for Genomics, Proteomics and Biomedicine (LCO6035)Partners involved:Institute of Biophysics, Academy of Science of the Czech Republic, v.v.i.Department of Biophysical Chemistry and Molecular Oncology(Doc. Miroslav Fojta - Coordinator)Masaryk Memorial Cancer Institute, BrnoDepartment of Oncological and Experimental Pathology(Doc. Bořivoj Vojtěšek)Faculty of Science Charles University, PragueDepartment of Analyt...

Photo Gallery

ConferencesHEIDELBERG August 2006MOSBACH March 2008PRAGUE-MEETING May 2008COPENHAGEN August 2008VIENNA January 2009L'ISLE SUR LA SORGUE September 2009MiscellaneousNEW YORK June 2010...

Projects

Projects Running: Finished:    ...

Výzkumná pracovnice – doktorandka / Výzkumný pracovník – doktorand

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výzkumná pracovnice - doktorandka / výzkumný pracovník - doktorand

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Senior researcher

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Senior researcherScientific department: Department of Plant Developmental GeneticsProject: TowArds Next GENeration Crops (OP JAK), CZ.02.01.01/00/22_008/0004581 Size of workload: 0.2Length of employment: 30. 6. 2028 Minimum educational attainment: Completed doctoral studies (Ph.D.) in the field of molecular biology, genetics, genomics or related fieldsQualificatio...

Internal Pages

Lab meetingsJournal clubImage galleryProtocolsLabStoreOrderSysList of booksPrivate...

2015 - XXXV. Moderní elektrochemické metody

XXXV. Moderní elektrochemické metodyPozvánkaVzor příspěvku ve sborníku...

Collaboration

Collaborations Genetics of allopolyploid nucleus Dr Christiane M. Ritz and Dr. Veit Herklotz, Senckenberg Museum of Natural History, Görlitz, Germany, https://www.senckenberg.de/en/institutes/museum-of-natural-history-goerlitz/ Prof Dr Andrew Leitch, School of Biological Sciences, Queen Mary, University of London, London E1 4NS, UK http://www.biology.qmul.ac.uk/research/(47 common papers 1995-2015) Dr Ilia Leitch, Jodrell Laboratory, Royal Botanic Gardens, Kew, http://www.kew.org/science-co...

Research profile

Research profileThe Global Structure of the Human Genome and Chromosome Territories in the Cell Nucleus and its Functional Consequences In eukaryotic cell nuclei genomic DNA is packaged into chromatin fibres. Properties of the chromatin fibres can be changed by modification of its constituent histone proteins and through interaction with structural non-histone proteins. These modifications contribute to packaging of the chromatin into higher-order structures, from the level of chromatin loop d...

Stixova et al., 2026

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Data

1. Submitted to JMCBMovie 1-3. Movement of PML bodies studied by time-lapse microscopy.Movie 1: Movement of PML bodies in LMNA wt cells.Movie 2: Movement of PML bodies in LMNA dn cells.Movie 3: Movement of PML bodies in LMNA dn cells treated by actinomycin D.2. J. Krejčí et al. (2009),J. Cellular Physiology3. J. Krejčí et al. (2009), Leuk. Res.,MELPHALAN AND CONTROL4. Šustáčková et al. (2011), J. Cellular PhysiologyTSACONTROLCONTROL5. D.Y.Orlova, Arrangement...

J. Cellular Physiology

12295502_ratio_peaks_mapToFeatures_All_Peaks.xls12301802_ratio_peaks_mapToFeatures_All_Peaks.xls...

MELPHALAN AND CONTROL

5287102_ratio_peaks_mapToFeatures_All_Peaks.xls5289502_ratio_peaks_mapToFeatures_All_Peaks.xls5501702_ratio_peaks_mapToFeatures_All_Peaks.xls...

2012 - International Conference: Functional genomics and proteomics for sustainable agriculture 2012

http://user.mendelu.cz/urban/konfer/FGPSA2012/...

HEIDELBERG August 2006

HEIDELBERG August 2006...

NEW YORK June 2010

NEW YORK June 2010...

Chromosomes and Sex Differentiation

Janousek B, Hobza R, Vyskot B (2012) Chromosomes and Sex Differentiation. In: PLANT GENOME DIVERSITY...

L ISLE SUR LA SORGUE September 2009

L'ISLE SUR LA SORGUE September 2009...

MOSBACH March 2008

MOSBACH March 2008...

Prague 2008

Prague 2008...

Eva Bártová CV

Bártová Eva, Prof., RNDr., Ph.D., DSc. Phone: +420541517140 Email: bartova@ibp.cz Eva Bártová Born 16th January 1968 in Kaplice (Czech Republic) as Eva Musilová Affiliation: Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, CZ-61265 Brno, Czech Republic   Education, training and employment: 1991: graduated in Experimental Biology, Faculty of Sciences, Masaryk University Brno 1992-1995: Ph.D. study: Department of Animal Physiology, Faculty of Science...

Publications

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Informace o provozu podatelny

Informace o provozu podatelny a o podmínkách přijímání dokumentů   Adresa pro doručování analogových dokumentů a přenosných technických nosičů dat: Biofyzikální ústav AV ČR, v.v.i. Královopolská 2590/135 612 00 Brno   Úřední hodiny podatelny:pondělí až pátek: 9:00-11:00, 12:00-14:00 Elektronická adresa podatelny:ibp@ibp.cz Identifikátor datové schránky:vpgnqkv Datové formáty, v nichž se dokumenty přijímají v digitální podobě: *.TXT prostý tex...

Group of the Structure and Function of the Cell Nucleus

Group of the Structure and Function of the Cell Nucleus Group leader: Prof. Eva Bártová, Ph.D., DSc. E-mail: bartova@ibp.cz; Tel.: +420 541517141 Deputy Group Leader: Ing. Magdalena Skalníková, CSc.   E-mail: skalnikova@ibp.cz; Tel.: +420 541517139   Department of Cell Biology and Epigenetics (DCBE) is interested in the studies of the structures and processes in the cell nucleus. We are focused on nuclear structures which are involved in transcription or DNA repair. Another field of our...

Marie Curie project - EU, PIRSES-GA-2010-269156-LCS

 Marie Curie project - EU, PIRSES-GA-2010-269156-LCSActivities 2011-2012:     http://lcs-programme.eu/Activities 2013:                A new contract 2013Meetings and publications 2011-2013Seminarin Brno,June 12, 2013Meeting St. Petersburg, July 6, 2013PDFPhotoMeeting in Brno, October 23, 2013Meetings in Russian Federation 2014PosterMeetingsPhotodocumentation- Moscow - university   &...

Czech-Norwegian Research Programme No.: 7F14369

Czech-Norwegian Research Programme (CZ09)Project title: Nuclear Architecture in the regulation of autophagy, DNA repair and gene expression Project No.: 7F14369 (2014-2017)Acronym: NuArch NuArch is based on the hypothesis that nuclear structural proteins, in addition to their roles in gene expression regulation, are also implicated in autophagy and DNA damage repair. Defects in these proteins are likely results in defective autophagy and DDR signaling, with important implications for c...

Czech-Norwegian Research Programme No.: 7F16012

Fund for Bilateral Relations in Czech-Norwegian Research Programme CZ09 Project title: Czech-Norwegian networking on nuclear structure and function Project No.: 7F16012 (2016-2017)Acronym:Cze-No-Net In April 2017 a meeting on nuclear architecture and function will be organized to strengthen the existing Czech-Norwegian co-operation between our laboratories (Laboratory of Molecular Cytology and Cytometry Institute of Biophysics [IBP] AVCR in Brno and Department of Oral Biology, Uni...

Strategie AV21 - Udržitelná produkce a spotřeba potravin

The Institute of Biophysics is part of the AV21 Strategy program “Sustainable Food Production and Consumption,” which focuses on comprehensive research into food production conditions, biotechnology, health, and social aspects. The program connects leading research institutions with the goal of improving agriculture’s resilience to climate change, enhancing soil and food quality, supporting the development of new crops, and contributing to a sustainable and healthy lifestyle.   https://w...

Research Funding

Our work is supported by funding from the Czech Science Foundation Junior Star (grant no. 22-20303M), the European Union’s Horizon 2022 Widera Talent program (ERA grant agreement no. 101090292), EMBO Installation Grant (grant no. EMBO IG-5689-2024), Czechoslovak Microscopy Society stipendia, Jihomoravske centrum pro mezinarodni mobilitu (JCMM) project scholarships for talented foreign students, Czech Academy of Sciences and internal IBP funding.     July 2025: Dr. Paolo Fagheraz...

Extrémní genomy

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Něco za něco, výhody dědičných nemocí

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DNA a RNA v pohybu

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Zkopíruj a ulož

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Heli

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Images

In the Laboratory of Cellular Biology and Epigenetics, we focus on studying lamins and the nucleolus using advanced confocal microscopy and deconvolution, while further improving super-resolution imaging methods. Deconvolution is used to enhance resolution, contrast, and signal-to-noise ratio, enabling more accurate reconstruction of the three-dimensional nuclear architecture and more detailed analysis of subnuclear structures.   Leica TCS SP-5 X High resolution confocal microscope Leica TCS S...

Collaborations

CollaborationsDepartment of Animal Physiology and Immunogy, Faculty of Science, Masaryk University, Brno Biomedical Center Dr. Miroslav MachalaDepartment of Chemistry and Toxicology, Veterinary Research Institute, Brno, Czech Republic Dr. Jan BouchalLaboratory of Molecular Pathology, Medical Faculty of Palacký University, Olomouc, Czech Republic Dr. Cornelia DietrichInstitute of Toxicology, Juhannes Gutenberg University, Mainz, Germany&nbs...

Research news

/getfile/?mode=readfile&path=/cms/Departments/DC/DC_report_2008.pdf...

Ph.D. positions in Cancer Research

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Research profile

Research Profile   Welcome to the Department of cytokinetics. Our research group has been established several years ago in order to pursue a research program focused on the study of the effects of metabolites of arachidonic acid (AA), eicosanoids, in signal transduction of cytokines at both cellular and molecular levels. This program is based on our previous original data, which demonstrated that the balance between cyclooxygenase (COX) and lipoxygenase (LOX) metabolites plays a signifi...

Links

Links Czech Society for Analytical Cytology (ČSAC)International Society for Analytical Cytology (ISAC)Society of ToxicologySociety of Environmental Toxicology and Chemistry (SETAC) DAVID Bioinformatics ResourcesHuman Protein AtlasAntibodypediaExactAntigenPlan your multicolor experiment using BD or INVG Fluorescence Spectrum Viewer....

Labmeetings

LabmeetingsPátek od 13 hodin v aule BFÚDatumJménoPracovištěNázevPo 5.10.2009 - klubovna BFÚPavel KrejčíPřF MU/BFÚ/UCLANF4499.10.2009Petr VaňharaPřF MUGrowth/differentiation factor-15 inhibuje diferenciaci osteoklastů.16.10.2009Alena VaculováKI/BFÚDoxorubicin zvyšuje citlivost buněk malobuněčného karcinomu plic, exprimujících kaspázu-8, k apoptóze indukované TRAIL(e...

Journal Club

Journal Clublast update 22.9. 2008- every Thursday at 7.45 AM- DC members can find full lenght articles, presentation and support articles here - javor\\group_rw\Journal_clubs200722.5. 2007intro - Karel Souček1. Craft, C. S., Romero, D., Vary, C. P. H., and Bergan, R. C. Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1 pathway. Oncogene, 2007.15.5. 2007intro - Eva LincováBryja, V., Gradl, D., Schambony, A., Arenas, E., and Schulte, G. beta-Arrestin is a necessa...

Protocols

Protocols...

List of Books

List of Bookslast update 27.11. 2008database in Endnote format is available at javor/group_rw/various/endnote/books_all.enl1. Biochemical indicators of radiation injury in man. Vienna: IAEA - international atomic energy agency, 1971.2. Abbas, A. K. and Lichtman, A. H. Cellular and Molecular Immunology, Fifth edition. Philadelphia: Elsevier Saunders, 2005.3. Adam, Z. and kolektiv, J. V. a. Hematologie II. Grada Publishing, spol. s r.o., 2001.4. Alberts, B., Bray, D., Johnson, A., Lewis, J., Raff,...

Private

Private...

Seminars

SeminarsZdeněk Andrysík, Ph.D. - Origins of Variability in the Cellular Response to p53 Activation (.pdf)...

Research news

/getfile/?mode=readfile&path=/cms/Departments/DPDG/newres.pdf...

Plant Transposable Elements

Kejnovsky E, Hawkins JS, Feschotte C (2012) Plant Transposable Elements. In: PLANT GENOME DIVERSITY...

Research news

/getfile/?mode=readfile&path=/cms/Departments/DFRP/newres.pdf...

Methods

MethodsIn vitro studies are carried out using the following cell systems: cultured HUVEC, HL-60, U937 cell lines and whole blood or isolated neutrophils (dextran sedimentation, Ficoll separation, ammonium chloride lysis). In cultured cells, interactions of neutrophils/macrophages with epithelial cells and the effect of RONM donors/inhibitors or antiinflammatory drugs on the functions and interactions of leukocytes and epithelial cells are studied. Interactions of neutrophils, macrophages, epithe...

Teaching

Teaching Radiation Biophysics (Masaryk University, Brno, CR, F8270) Structure and function of eukaryotic chromosomes (Masaryk University, Brno, CR, C9041) Radiation Biophysics (Heidelberg University, Heidelberg, Germany) Nanoscale microscopy and biophysical applications (Mikroskopie auf der Nanoskala und biophysikalische Anwendungen) (Heidelberg University, Heidelberg, Germany) Selected topics of radiation biophysics (Ausgewählte Themen der Strahlenbiophysik) (Heidelberg University, Heidelberg...

2012 - International Workshop – Structural and functional DIVERSITY OF GENOMES

http://www.ceitec.eu/cooperations/international-workshop-structural-and-functional-diversity-of-genomes/...

Info about the department

Department of Structure and Dynamics of Nucleic Acids Our main research aim is to provide unique insights into the role of molecular interactions in structure, dynamics, function and evolution of nucleic acids (RNA, DNA, and their complexes with other molecules), as well as chemical processes involved in origin of life. Our research is highly interdisciplinary and we wish to bring modern physical-chemistry insights into structural and molecular biology, biochemistry and bioinformatics. We use a ...

PR specialista

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Postdoctoral fellow

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno  announces a selection procedure  Job title: Postdoctoral fellowScientific department: Cell Biology and Radiobiology (Assoc. Prof. Falk)Project: GAČR 23-04769 Telomere biology of Trypanosomatids: contrasting features point to diverse strategiesGAČR 23-06643S Disposition, distribution, and processing of DNA lesions in the genome of Arabidopsis thaliana plants defective in DNA repair and nucleosome assem...

Doktorand/ka

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: PhD studentScientific department: Biophysical Chemistry and Molecular OncologyProject: GAČR 22-11252S, Electroactive and fluorescent modifications of nucleic acids for structure & interaction studies and for applications in diagnostics Size of workload: 0.5Length of employment: 31st August 2028 Minimum educational attainment: Master’s degreeQualification le...

Teaching

Faculty of Science, Masaryk University, Brno Full-time semester courses PřF:Bi5220 Immunology PřF:Bi6728 Blood Physiology PřF:Bi9901 Free radicals in animal physiology PřF:Bi9902 Photobiology   Contribution to the lectures PřF:Bi9393 Analytical cytometry PřF:Bi9904 Journal club – animal physiology I PřF:Bi9905 Journal club – animal physiology II PřF:Bi0005 Introduction to the study of Special Biology PřF:Bi9907 Laboratory seminar OFIŽ   Bachelor, diploma and PhD thesis at Facul...

CV

/getfile/?mode=readfile&path=/cms/Departments/DSDNA/cvjs.doc...

Circular dichroism

Circular dichroismVorlíčková, M., Kypr, J. and Sklenář, V.: NUCLEIC ACIDS: (c) SPECTROSCOPIC METHODS, Encyklopedia of Analytical Science, vol. 6, sec. ed., Elsevier, Oxford(2005) 391-399.[Abstract, PDF, picture]Kypr, J. and Vorlíčková, M.: Circular dichroism spectroscopy reveals invariant conformation of guanine runs in DNA. Biopolymers67 (2002) 275-277. [Abstract, PDF]...

Citations

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Collaboration

Collaborations We are open for cooperations in all areas of our research, with experimental and computational groups. We have a wide range of international cooperations across the globe with leading groups in computational chemistry and experimental groups. The latest active cooperations include: Prof. Michal Otyepka, Prof. Petr Jurečka, Prof. Pavel Banáš, Dr. Marie Zgarbová (Palacký University, Olomouc, Czech Republic) - RNA and protein structural dynamics, NA force fields, quantum chemis...

Postdoc

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Public information

Public informationKlíčové biomolekuly jako DNA, RNA a bílkoviny uskutečňují i ty nejjemnější biologické funkce především na základě svých unikátních trojrozměrných (3D) struktur. Příroda dokázala v průběhu evoluce vyvinout neuvěřitelné bohatství trojrozměrných architektur biomolekul. Nalezení vztahu mezi primární genetickou informa...

Projektový manažer

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Photos

Photos of the laboratory...

Postdoc position

Postdoctoral (junior) research position at the Department of Structure and Dynamics of Nucleic Acids Joint Laboratory of theCentral European Institute of Technology (CEITEC), Masaryk UniversityandInstituteof Biophysics, Academy of Sciences of the Czech Republic,Brno, Czech Republic Please contact Prof. Jiri Sponer for further detailssponer at  ncbr.muni.cz, fax: 420 5412 12179, phone: 420 5415 17133http://www.ibp.cz/http://www.ibp.cz/en/departments/structure-and-dynamics-of-nuclei...

Doktorand

Institute of Biophysics of the Czech Academy of Sciences announces Position of a young scientist - PhD Student (R1), Department of Plant Developmental Genetics, part-time job (20 hours per week), contract for one year, opening from 1 March 2022.   Requirements: Finished master degree in microbiology, biotechnology, molecular biology or related field Knowledge of basic microbiology and molecular biology techniques Ability to carry out wetlab research and interpret the results Active English co...

Papers related to formamide in prebiotic chemistry

List of papers related to formamide in prebiotic chemistry published by us and others:1.            Saladino, R.; Crestini, C.; Costanzo, G.; Negri, R.; Di Mauro, E. A possible prebiotic synthesis of purine, adenine, cytosine, and 4(3H)-pyrimidinone from formamide: Implications for the origin of life. Bioorganic & Medicinal Chemistry2001,9(5), 1249-1253. http://dx.doi.org/10.1016/s0968-0896(00)00340-02.      ...

Research profile

Research profileThe laboratory studies conformational properties of the most important molecule in Nature - DNA. DNA can exist in conformations substantially different from the classical Watson-Crick double helix. Its structure can vary from the anti-parallel Watson-Crick helix in minor ways like nucleotide geometry, but can also vary significantly in parameters including double-helix handedness, orientation of strands, type of base pairing, and the number of associated strands. The capability o...

Abstracts

AbstractsKypr, J., Kejnovská, I., Renčiuk, D., and Vorlíčková, M.: Circular dichroism spectroscopy and conformational properties of DNA. Nucleic Acids Research, 37, 1713-1725Here we review studies that provided important information about conformational properties of DNA using circular dichroic (CD) spectroscopy. The conformational properties include the B-family of structures, A-form, Z-form, guanine quadruplexes, cytosine quadruplexes, triplexes and other less characteri...

2012 - 12th International Workshop on Radiation Damage to DNA

http://radamdna.odz.ujf.cas.cz/12th International Workshop on Radiation Damage to DNA...

Aktualní vědecký program

  V rámci tohoto plánu nabízíme disertační, diplomové případně bakalářské práce.     Rámcová představa zaměření vlastního výzkumu pro následujících 6 let (2015+), aktuální témata můžete nalézt na úvodní stránce   Základní cíl výzkumu.Základním cílem výzkumu je pochopení struktury, dynamiky, funkce a evoluce molekul nukleových kyselin (DNA a RNA) pomocí nejmodernějších počítačových metod. Zdůvodnění výzkumu a výchozí bod laboratoře.M...

Teaching

Speciální přednášky DSNAMichaela Vorlíčková se podílí na následujících přednáškách MU: Metody chemického výzkumu, Biofyzikální chemie, Chemické vlastnosti, struktura a interakce nukleových kyselin, Pokročilé biofyzikální metody v experimentální biologii, Experimentální metody biofyziky Výz...

Library

Library Search in IBP library funds - database ALEPH Journals since 1955 available at the IBP Library rules Library of the Academy of Sciences of the Czech Republic Licensed databases: ACS (American Chemical Society) Wiley Online Library, through Suweco Oxford Reference Online Science Direct (Elsevier) 5. collection, through Suweco Springer Link (Springer, Kluwer), through Suweco Ulrich's Periodical Directory Information sources, accessible from IBP Local Area Network SUWECO - nex...

Documents and links

Documents and links Charter for researchers (.pdf)Full Text of the Foundation Deed of the Institute of Biophysics of the Czech Academy of Sciences (.pdf)Ethical Code of the Institute of Biophysics of the CAS (.pdf)Internal regulation on the protection of intellectual property rights resulting from research, development and innovation activities or created otherwise in the Institute of Biophysics of the CAS, v. v. i. (.pdf)The Career Development Rules of Research Workers at Institute of Biophysic...

České biofyzikální sdružení

https://cbpa.cz/...

Research profile

 Structure of sex chromosomesFunction of sex chromosomes-linked genesStability and integrity of cell nucleusStructure of sex chromosomesThe existence and evolution of sex chromosomes is a basic question in evolutionary biology. While sex chromosomes in the majority of animal species are ancient, plant sex chromosomes have evolved relatively recently, making dioecious plants good models for the study of early steps of sex chromosome evolution. Silene latifolia (syn. Melandrium...

Introduction to Developmental Biology and Genetics

DOWNLOAD pdfVyskot, B.: Přehled vývojové biologie a genetikyIntroduction to Developmental Biology and Genetics (in Czech)Skripta pro doktorské studium molekulární biologie v biomedicínských vědách.Vydal Ústav molekulární genetiky AV ČR, ISBN 80-902588-1-6, 241 stran, náklad 450 výtisků, Praha 1999Developmental Genetics(B. Vyskot, syllabus of the winter courses at the Faculty of Science, Masaryk Univers...

Evolutionary Genomics

Eduard Kejnovský and Roman Hobza:Evolutionary genomicsSemestral course (2/0, spring semester) for students of the Faculty of Science, the Masaryk University 1. Origin of lifeCosmological introduction. Atributes of life. Origins of life. First genetic systems based on proteins or nucleic acids. Ribozymes. Origin of genetic code and proteosynthesis. Clay theory. Takeover of genetic information by DNA.  Panspermia and extremophiles. Silicon based life, other solvents than water.&nb...

Links

Links http://iupab.org/ http://iupab.org/ http://www.med.muni.cz/biofyz/ https://www.mff.cuni.cz/to.en/ https://www.faf.cuni.cz/Fakulta/Organizacni-struktura/Katedry/Katedra-biofyziky-a-fyzikalni-chemie/ http://biofyzika.upol.cz/en/ http://www.physics.muni.cz/ufkl/index.en.shtml https://www.fbmi.cvut.cz/...

Postdoctoral position

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Genetic Engineering

Roman Hobza: Genetic EngineeringSemestral course (autumn semester, 2/2)Mendel University of Agriculture and Forestry, Faculty of Agronomy, branch Plant BiotechnologyStructure of plant genome Complexity of plant genome, nuclear and extranuclear DNAOrganization of plant chromosomeCoding and non-coding DNARepetitive DNAsequences, transposonsGeneral principles of manipulation with nucleic acids Isolation of DNA and RNASeparation of DNA and RNA: centrifugation, electrophoresisHybridization of n...

Plant Physiology

Procházka, S. et al.:Fyziologie rostlin[Plant Physiology, a university textbook, in Czech]Vydala Academia, ISBN 80-200-0586-2, Praha 1998 DOWNLOAD pdfBoris Vyskot: Genetická podmíněnost fyziologických procesů(kapitola 16, str. 432-458) Abstrakt:V průběhu posledních dvou desetiletí bylo dosaženo velkého pokroku v oblasti molekulární a buněčné genetiky rostlin. Stalo se tak díky objevu možnosti vná...

Sex Determination in Plants

Ainsworth, C. C. [ed.]: Sex Determination in Plants(BIOS Scientific Publishers Ltd, Oxford, ISBN 1 85996 042 1, Oxford, United Kingdom 1999)Chapter 6 (pp. 101-120) - Boris VyskotThe role of DNA methylation in plant reproductive developmentAbstract:During the last few years, data have accumulated which show that DNA methylation and core histone acetylation play an important role in the long-term control of gene expression and development. They are obviously responsible for (or at least accompany)...

Molecular Biology and Genetics

Vyskot, B.: "Srovnávací vývojová biologie" and"Epigenetická dědičnost".  In: Molekulární biologie a genetika VIII[Molecular Biology and Genetics vol. VIII, a university textbook, in Czech]Skripta pro postgraduální studium biomedicínských vědVydal Ústav molekulární genetiky AV ČR (ISBN 80-902588-0-8), str. 5-24, Praha 1998Srovnávací vývojov&aacut...

Pokroky v molekulární biologii

http://www.ibp.cz/getfile/?mode=readfile&path=/cms/Departments/DPDG/e-learning/pdf/Vyskot_06_Pokroky.pdf...

Epigenetics

DOWNLOAD pdfBoris Vyskot: EpiGenetikaOlomouc 2010UNIVERZITA PALACKÉHO V OLOMOUCIPŘÍRODOVĚDECKÁ FAKULTAOponenti: RNDr. Aleš Kovařík, CSc.Mgr. Jaroslav Fulneček, CSc.1. vydání© Boris Vyskot, 2010ISBN 978-80-244-2534-4Obsah 1   ÚVOD 2   HISTORIE EPIGENETIKY 3   MECHANIZMY EPIGENETICKÝCH PROCESŮ3.1  Metylace cytozinu3.1.1  Distribuce 5-metylcytozinu3.1.2  DNA metyltran...

Y Chromosome Evolution

Vyskot B, (2012) Y Chromosome Evolution. In: ENCYCLOPEDIA OF GENETICS...

Software

 Bisprimer- A Program for the Design of Primers for Bisulfite-BasedGenomic Sequencing of Both Plant and Mammalian DNA Samples pdf file (abstract)exe file(download) ...

Interdoc project

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E-mail HORDE

https://webmail.ibp.cz/...

E-mail HORDE - mobile

/gohorde_mimp.php...

SSH Client

http://195.178.68.10/ssh.php...

Klíčový vědecký pracovník

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Epigenetics and chromatin structure

Epigenetics and chromatin structure Epigenetics, in the recent years, has focused on defining mechanisms of transmission of information which regulates gene expression in heritable fashion. This transgenerational epigenetic inheritance defines early pluripotent state of each cell and play an important role in development of each organism. Thus, the understanding of regulatory pathways affecting the transmission of epigenetic marks is essential for interpretation of important traits in plants and...

Instructions

EDUROAMConfiguration eduroam network - Windows XPChange settings according to following instructions. In some versions of Windows may be slightly different dialogs.In the properties of wireless network, select eduroam and click on the button Properties. If the network don't exist, create it using the Add button.In the properties of the Protocol PEAP write radar.ibp.cz and select the list of certification authorities AddTrust External CA Root.Close all open dialogs by pressing OK. In this mom...

OP TAK - Výzkum a vývoj zdravotnických prostředků ve společnosti Contipro a.s. pro léčbu a prevenci patologických stavů spojených s extrakcí zubů

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The mission and conception of the Institute of Biophysics

The mission and conception of the Institute of Biophysics The Institute of Biophysics, Czech Academy of Sciences (IBP) represents a cohesive unit profiling itself in the research of basic molecules of life, which are nucleic acids. Also, we aim to study the biophysical aspects of cellular systems and their organization. We are addressing these tasks at the physical, chemical, biological, and medical levels. Specifically, researchers focus on (i) the structural properties of nucleic acids. For th...

Media & popularization

Eduard Kejnovský - VESMÍRCo Gregor Mendel nevěděl?Jakou část naší bytosti určují geny a jakou prostředí? Co rozhoduje o tom, jak vypadáme, jak se chováme, jak jsme odolní vůči nemocem. Genetici říkají, že za většinu našich ...Vesmír 92, 442, 2013/7.(.pdf) Odkud pochází „cizí DNA “?Odkud pocházejí naše geny? Nikoho nepřekvap...

Position of a young scientist (R1-R3)

Institute of Biophysics of the Czech Academy of Sciences announces Position of a young scientist (R1-R2), Department of Molecular Cytology and Cytometry,   full-time job (40 hours per week), contract for an indefinite period, opening from 1 February 2022.   Department of Molecular Cytology and Cytometry is announcing the position of a young scientist who deals with the regulation of replication, the cell cycle in embryonic stem cells, and during their differentiation into cardiomyocytes. Appl...

Course

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IBP CAS/FNUSA-ICRC shared equipment

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Home

Workshop: „Unraveling and targeting sequence- and structure-specific p53-DNA interactions in development and disease“September 15-19, 2015, Brno, Czech Republic...

Mission

Workshop: „Unraveling and targeting sequence- and structure-specific p53-DNA interactions in development and disease“Four groups, four different approaches, twenty participants and huge amount of ideas. Our intensive workshop is designed to promote cooperation among our different groups with similar research topics to elevate our competitiveness in international scientific environment. This new professional opportunity is part of the Academy of Sciences initiative and will impulse fo...

Garants

Workshop: „Unraveling and targeting sequence- and structure-specific p53-DNA interactions in development and disease“Joanna Zawacka-Pankau,Karolinska Institutet, SwedenJoanna Zawacka-Pankau is Assistant Professor and junior PI in Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Stockholm, Sweden. Joanna Zawacka-Pankau obtained her PhD in biochemistry from the University of Gdansk, Poland in 2005. Under supervision of Prof. Podhajska she investigated the ther...

OP JAK

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Program

Workshop: „Unraveling and targeting sequence- and structure-specific p53-DNA interactions in development and disease“September 15-19, 2015 Morning sessions:Plenary lectureYoung researcher project lecturesAfternoon sessions:            Methodological approaches            Brainstorming session focused to cooperation         &nb...

Venue

Workshop: „Unraveling and targeting sequence- and structure-specific p53-DNA interactions in development and disease“Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i.  September 15-19, 2015, Brno, Czech Republic...

Contacts

Workshop: „Unraveling and targeting sequence- and structure-specific p53-DNA interactions in development and disease“Organizing committee: Joanna Zawacka-Pankau, Karolinska Institutet, Sweden; Elena V. Savvateeva-Popova, Pavlov Institute of Physiology, St. Petersburg, Russia; Alberto Inga, University of Trento, Italy; Václav Brázda, Institute of Biophysics AS CR, v.v.i., Brno, Czech Republic Václav Brázda, Ph.D.Institute of Biophysics, Academy of Scie...

Promiskuitní DNA

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Sponsors

Workshop: „Unraveling and targeting sequence- and structure-specific p53-DNA interactions in development and disease“Workshop is supported by Academy of Sciences Czech Republic, University of Trento, Italy and commercial partners:Thank you for your cooperation and support.September 15-19, 2015, Brno, Czech Republic ...

2015 - SYLICA Workshop on electrochemical analysis of biomolecules and its applications in diagnostics

SYLICA Workshop on electrochemical analysis of biomolecules and its applications in diagnosticsorganized by Central European Instritute of Technology (CEITEC)in collaboration with Institute of Biophysics, ASCR, v.v.i., Metrohm Česká republik, s.r.o. and BioTech, a.s.The workshop is devoted to electrochemical properties of nucleic acids, protein and carbohydrates, their modification with redox and other labels, and applications in biosensing and molecular diagnostics. The goal of the...

ORGANONET 2014 CONFERENCE

http://www.organonet.cz/...

2014 - 47th Heyrovský Discussion: Electrochemistry of Organic and Bioactive Compounds

http://www.jh-inst.cas.cz/~hdisc/2014/...

2014 - XXXIV. Moderní elektrochemické metody

XXXIV. Moderní elektrochemické metody(.pdf)...

2013 - SYLICA Workshop on chemical modification and redox labeling of biopolymers for biosensing

http://www.ceitec.eu/sylica-workshop-on-chemical-modification-and-redox-labeling-of-biopolymers-for-biosensing/t1516...

2013 - Conference Analytical Cytometry VII

http://www.csac.cz/conference2013/...

International Conference on Cell Biology and Radiobiology 2016, Brno

International Conference on Cell Biology and Radiobiology 2016, BrnoThe International Conference on Cell Biology and Radiobiology – The Satellite Conference to the 6th International Conference on Genomics & Pharmacogenomics (held in Berlin, Germany, in September 12th– 14th, 2016) – is organized by the Institute of Biophysics, v.v.i., in Brno in 8th– 10thSeptember 2016.The conference is focused on the most recent advances and applications in different fields of cell bi...

2012 - International Conference - 45th Heyrovský Discussion

http://www.ceitec.eu/45th-heyrovsky-discussion-electrochemistry-of-biopolymers-and-bioactive-compounds/...

2012 - The International PhD Student Conference on Experimental Plant Biology

http:/www.biomania.cz/phd-conference...

2011 Workshop on Animal Physiology and Immunology

WORKSHOP ON ANIMAL PHYSIOLOGY AND IMMUNOLOGYBRNO, June 23-24, 2011organised byInstitute of Biophysics, Academy of Sciences of the Czech Republic, BrnoandDept. of Animal Physiology and Immunology, Faculty of Science, Masaryk University, BrnoMeeting TopicsThe workshop is planned as a conference of PhD students with scientists’supervision.Biology and physiology of phagocytesComparative innate immunityCell and molecular physiologyBehavioral physiologyModulation of physiological and immune proc...

2009 - Conference Analytical Cytometry V

http://csac.cz/conference2009/...

2008 - Electrochemistry of Nucleic Acids and Proteins

Satellite Symposium to ESEAC 2008(held in Prague, June 16-19, 2008)The symposium is dedicated to the 60th birthday of Prof. Joseph Wang Institute of Biophysics, v.v.i.Academy of Sciencesof the Czech Republic ScopeThe Brno satellite symposium will extend the scope of the Prague ESEAC meeting within the area of electrochemistry of nucleic acids and proteins, including recent applications in biosensing. The symposium will deal with the following topics:general electrochemistry and electro...

Events with International Participation since 2005

Events with International Participation Organised or Co-Organized by the Institution in 2005–2009NEvent NamePlaceDate(s)Participants (from abroad)1Biochemistry, Structural and Cellular Biology of Non-Classical Antitumor Platinum CompoundsJerusalemApril 17 – 18, 200542 (37 from abroad)2Metal Compounds in the Treatment of Cancer and Viral DiseasesBrnoJune 15 – 18, 2006145 (132 from abroad)3Structure, recognition, and processing of DNA damage by antitumour metal-based compoundsVer...

Vesmír glosa

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Older conferences

Older conferencesCOST Chemistry D20, 10th Management Committee Meeting and Final Conference, "Metal Compounds in the Treatment of Cancer and Viral Diseases"; June 15 - 18, 2006, BrnoPlant Reproduction: From Mendel to Molecular Biology.XIth International Conference on Plant Embryology. September 1-4, 2003Analytická cytometrie IV / Česká společnost pro analytickou cytologiiBiophysics of the Genome, 2.-4. April, 2003Symposium teoretické a aplikovan&ea...

General information

Center of Information Technologies Head: Ing. Jan Kovařík Technician: David Král Librarian: Bc. Jana Poláková (MVS, ALEPH) Standard services of the Centre: Network (Computer & Telephone) and Computers Care on operation, servicing and development of the IBP local area network (LAN) Care on operation of the connection of the IBP LAN to Brno Academic Computer Network and to the Internet Care on exchange and IP telephony Maintenance of the IBP e-mail server, including antiv...

Přístup k informacím

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Ph.D. student s technickým zaměřením

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IT administrátor

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Public procurements

Public procurements https://zakazky.ibp.cz/ https://nen.nipez.cz/profil/ibp...

Research profile

  Research profile The main research objective of the Department is to increase knowledge and understanding of the mechanisms of biological (antitumor and antibiotic) action of metallodrugs and to use this enhanced knowledge to develop new classes of metallodrugs with truly novel mechanisms of action and novel spectra of biomedical activity. The methods, which we had available in the last period, enabled us to obtain a more complex view on the mechanism of action  of new metallodrugs based on...

Info about the department

Department of Biophysics of Nucleic Acids Head: Daniel Renčiuk   Structural properties and interactions of nucleic acids important from the point of view of their function or pathology Biophysical characterisation of unusual structures of nucleic acids In vivo / in vitro detection of unusual structures of nucleic acids Interaction of unusual structures with proteins and small-molecule ligands  ...

Přehled dohod o spolupráci mezi BFÚ a vysokými školami

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Finanční manažer

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Postdoctoral biologist

DESCRIPTION: We are seeking a motivated postdoctoral biologist with background in cancer biology, to investigate the pathological plasticity and heterogeneity of tumours, its role in cancer dissemination and therapy resistance. Project: Multiparametric single cell analysis of tumor cells and microenvironment in the triple-negative breast cancer PROFILE OF CANDIDATE: Ph.D. in cell or cancer biology/physiology/biochemistry/molecular biology/immunology/pharmacology high motivation and enthusi...

Building a Sustainable Laboratory Culture

In our lab, sustainability is not a side project. It is part of how we work every day. From mindful ordering to creative reuse, we believe that caring for the environment goes hand in hand with doing good science. Our approach is simple: reduce, reuse, rethink, and recycle. But most importantly, we make it fun and collaborative. Here are some of the ways we do it: 🔄 We reuse and Repurpose: Why throw something away if it can serve again? We refill and autoclave our tip boxes instead of buying ...

Projects

Projects Biophysical Properties of Biologically and Medically Important Regions of Human DNA (2007 - 2011), Grant Agency of the Academy of Sciences of the Czech Republic Tetraplexes in the Human Genome (2007 - 2009) Grant Agency of the Czech Republic Tetraplexes of DNA and Their Occurrence in the Human Genome (2002 - 2006), Grant Agency of the Academy of Sciences of the Czech Republic Conformational Polymorphism of DNA Molecules Containing Trinucleotide Repeats Associated with Genetic Diseases ...

Doktorand

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Odborný vědecký pracovník - projekt OP VVV

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Ošetřovatel – ošetřovatelka malých laboratorních zvířat

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Rebutal PubPeer

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Research news

https://www.ibp.cz/getfile/?mode=readfile&path=/cms/Departments/DBNA/newres.pdf...

Odborný pracovník

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Vedoucí výzkumné skupiny

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Vědecký výzkumný pracovník

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IBP co-organizes international conference „Bioelectrochemistry and Bioelectronics of Macromolecules“

IBP co-organizes international conference „Bioelectrochemistry and Bioelectronics of Macromolecules“ http://bioelectrochemistry.ceitec.cz/...

Odborný pracovník

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IBP co-organizes international conference „XXXVIII. MODERN ELECTROCHEMICAL METHODS“

IBP co-organizes international conference „XXXVIII. MODERN ELECTROCHEMICAL METHODS“ http://www.bestservis.eu/en/upcoming/mem38en/30/...

Postdoktorand

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Vědecký pracovník

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Výzkumný technik

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For public

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IT Specialista

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Výsledky výzkumu

/getfile/?mode=readfile&path=/cms/Departments/DMBP/selected_results_END.pdf...

Media releases

Media releases Lidové noviny21. dubna 2018 Nejcitovanější vědci jsou chemici Hvězdárna a planetárium Brno5. dubna 2018 VZNIK ŽIVOTA – NEJVĚTŠÍ TAJEMSTVÍ VESMÍRU Lidové noviny22. prosince 2017 Víme, jak začal život Interview10/2017 Judit a Jiří Šponerovi: Jak vznikla první živá molekula na této planetě RCPTM NEWSLETTER3/2017 http://www.rcptm.com/newsletter/03-2017-CZ.pdf Akademie věd České republiky6. října 2017 http://www.avcr.cz...

News

News News from IUPAB 2021:  IUPAB.News-79 News from IUPAB 2021:  IUPAB.News-78 IUPAB.News-77 IUPAB.News-76 News from IUPAB 2020:  IUPAB.News-75 IUPAB.News-74 IUPAB.News-73 News from IUPAB 2019:  IUPAB.News-72 IUPAB.News-71 IUPAB.News-70 News from IUPAB 2018:  IUPAB-news-69 IUPAB.News-68 IUPAB.News-67 Inivitation: Invitation on the lecture 2021: Dr. Hector Mertinez-Seara Monne: Exploring the cell-membrane proximal region using classical molecule dynamics simulations 1st June 2021 For more ...

Relikty

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Aby se kamínky nevydrolily

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Post

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Group of Gabriela Ambrožová

Gabriela Ambrožová, Mgr., Ph.D.   Kristýna Turková, Mgr., Ph.D. Miriam Sandanusová, Mgr. Martin Šindelář, Mgr. Eva Pecháčková,Bc. Lucia Caleková, Bc. Mlčeková Veronika Orlovská Júlia     Myeloid cells and regulation of their functions Myeloid cells represent a heterogeneous group of blood cells, responsible for, besides other functions, for triggering and regulating immune response and the subsequent inflammatory process. While acute inflammation is directed toward invading p...

Kontakty

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Ph.D. student

DESCRIPTION: We are seeking a motivated student for a Ph.D. in the Department of Cytokinetics at Institute of Biophysics of the Czech Academy of Sciences, Czech Republic. Project: Multiparametric single cell analysis of tumor cells and microenvironment in the triple-negative breast cancer, Toll-like receptors in prostate carcinogenesis and therapy resistance   PROFILE OF CANDIDATE: finished M.S. degree in biology, biochemistry, pharmacology recommendation for admission to the doctoral program...

Výzkumný pracovník

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Odborný/á referent/ka MTZ a ASEP

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Nová strana

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Vědecký pracovník

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Evoluce lidských pohlavních chromozomů

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Mikrosatelitní DNA

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Život jako film, experiment jako momentka

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Acytota, další říše života?

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Sex chromosomes

Sex chromosomes The existence and evolution of sex chromosomes is a basic question in evolutionary biology. While sex chromosomes in the majority of animal species are ancient, plant sex chromosomes have evolved relatively recently, making dioecious plants good models for the study of early steps of sex chromosome evolution. Silene latifolia (syn. Melandrium album or white campion) is the dioecious plant possessing heteromorphic sex chromosomes, X and Y. It formally resembles the mammalian type ...

Administrátor projektu

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Postdoktorand

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Annual Reports

Economic Reports Economical report of IBP for the year 2017 Economical report of IBP for the year 2016 Economical report of IBP for the year 2015 Economical report of IBP for the year 2014 Economical report of IBP for the year 2013 Economical report of IBP for the year 2012 Economical report of IBP for the year 2011 Economical report of IBP for the year 2010 Economical report of IBP for the year 2009 Economical report of IBP for the year 2008 Economical report of IBP for the year 2007 Economical...

Doktorand

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Vedoucí technické správy

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Postdoc

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Group of Lukáš Kubala

Lukáš Kubala, doc., Mgr., Ph.D.   Petra Daďová, Mgr. Michaela Chorvátová, Mrg.  Radim Jaroušek, Mgr. Daniela Rubanová, Mgr. Josef Bryja, Bc.       Currently ongoing projects Role of myeloperoxidase in the regulation of immune system function The neutrophil-derived heme enzyme myeloperoxidase (MPO) has been shown to be critically involved in the pathophysiology of cardiovascular diseases, since it is now widely acknowledged that MPO itself is a major pro-inflammatory mediator involve...

Program PPLZ

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Grantové agentury

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Řešené projekty

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Program interní podpory výzkumu

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test

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Pracovník údržby venkovního areálu

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Cesta k postneodarwinismu

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Vesmir_Skakajici geny

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Odkud pochází "cizí DNA"?

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Co Gregor Mendel nevěděl

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_Vesmir_Skakajici geny_2

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Vesmír Esej

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Vesmir_X crossroad glosa

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Skákající geny v mozku a rakovinných buňkách

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Evoluce ve zkumavce

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Genetický kód

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Group of Lenka Šindlerová

Lenka Šindlerová, RNDr., Ph.D. Petra Raptová, Mgr. Veronika Skočková, Mgr.   Pro-inflammatory effects of LPS of cyanobacterial water bloom from freshwater reservoirs in the Czech Republic Cyanobacterial water blooms (HAB) in freshwater reservoirs represent a serious human health hazard. They might produce high amounts of well-recognized hazardous cyanotoxins like microcystin, cylindrospermopsin, nodularin and others. At the same time, they are the source of endotoxins, lipopolysaccharides...

Výzkumný pracovník

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Vědecko-výzkumný pracovník

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Council of the Institute

Council of the Institute Chairman: RNDr. Aleš Kovařík, CSc.Deputy chairman: doc. RNDr. Miroslav Fojta, CSc. Internal members:prof. RNDr. Jiří Šponer, DrSc.prof. RNDr. Jan Vondráček, Ph.D.doc. RNDr. Eduard Kejnovský, CSc.doc. RNDr. Martin Falk, Ph.D. External members:prof. RNDr. Jan Šmarda, CSc.doc. Mgr. Jan Paleček, Dr. ret. nat.prof. Mgr. Martin Lysák, Ph.D., DSc.  ...

Ovlivníme myšlenkami naši DNA?

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Basic Information

Basic information about the InstituteThe Institute was established on 1st January 1955 from the Biophysical Laboratory of the Academy of Sciences founded one year earlier. In 2007 the Institute converted into a public research organization according to the law no. 341/2005 Sb. The mission of the Institute is a basic research of the structure, function and dynamics of biological systems (biomolecules, cell components, cells and cell populations) using ...

Výzkumný pracovník - doktorand

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Genome dynamics

Genome dynamics     The emerging paradigm represents a genome as a very dynamic system generating its own rearrangements where mostly transposable elements but also (micro)satellites and promiscuous DNA are the key players. Recent studies showed that epigenetics can shape dynamics of transposable elements thus responding to environmental changes.      We study behavior of transposable elements and other dynamic genome components like microsatellites and promiscuous DNA in non-recombinin...

Zámek a klíč

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Initial phase

Initial Phase In 2020, we launched a long-term GAP Analysis process, revealing gaps in the 40 C&C principles. Based on discussions with scientists of all levels, administrative and technical staff, a GAP Analysis was performed and an Action Plan for the next four years was prepared. Implementing the HRS4R strategy is one of the ways to demonstrate that the IBP supports its scientists. The whole process was supervised by the Expert Team (the Director’s decision from 08/2020). This team aske...

Odborný vědecký pracovník

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Finanční účetní

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Právník, specialista VŘ

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Collaboration

Collaboration Prof. RNDr. Ivan Raška, DrSc. Institute of Cellular Biology and Pathology the First Faculty of Medicine, Charles University in Prague. Electron microscopy   Prof. Ohad Medalia Department of Biochemistry University of Zurich Winterthurerstr. 190 CH-8057 Zurich A new LA CSF project application   Mgr. Gabriela Lochmanová CEITEC Brno, Research group of prof. Zbyněk Zdráhal Kamenice 753/5 625 00 Brno ...

Postdoc

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Collaborations

International Prof. Peter Ertl, Cell Chip Group, Technical University of Viena, Austria Assoc. prof. Anna Klinke, Herz- und Diabeteszentrum NRW, Ruhr University of Bochum, Germany Prof. Stephan Baldus, Heart Center, University of Cologne, Germany   National Prof. Martin Weiter, Material Research Centre, Brno University of Technology, Czech Republic Prof. Robert Mikulík, International Research Center, St. Anne’s University Hospital in Brno, Czech Republic Prof. Jiří Damborský, Loschmict La...

Bioinformatics

Bioinformatics Our group has experience in a wide range of bioinformatics approaches including genomics, transcriptomics, statistics and software development. In our studies we used several model organisms and also we are opened for any collaboration. In genomics we participate genome assembly projects, genomic data analysis (BAC sequencing, Illumina and ONT whole genome sequencing, amplicon sequencing) gene prediction and genome annotation, genome wide association studies (GWAS), Chip-seq, tran...

Technický pracovník výzkumu

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Position of Director of the Institute

Call for Applications for the Position of Director of the Institute The Council of the Institute of Biophysics of the CAS /IBP/ is accepting applications for the position of Director of the Institute. Expected term of office is from May 1, 2022 to April 30, 2027. See the Institute website for more details: https://www.ibp.cz/en/about-ibp/basic-information. Requirements: full legal capacity1), no criminal records and no sanctions according to Section 17 (4) (b) and (c) of Act No 341/2005 Coll...

Labmeetings

LabmeetingsLabmeetings in English are organised each Friday at 10am in the library.All contributors are welcome !...

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Department´s News

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Group of Milan Číž

Milan Číž, RNDr., Ph.D. Adéla Dvořáková, Mgr.   It is known that histone modifications may interfere with epigenetic changes in neutrophils. Histone H3 citrullination leads to chromatin decondensation and promotes DNA cleavage which results in altered gene expression profile. We hypothesize that hypoxia enhances the activity of peptidylarginine deiminase and production of citrullinated proteins, including histone H3 proteins in neutrophils. Altered gene expression is in-turn, manifested ...

Ph.D. student / postdoc

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Krejci et al., 2023 PhysRes

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Group of Ondřej Vašíček

Mgr. Ondřej Vašíček Ph.D.     Research Topic: NATURAL AND SYNTHETIC PSEUROTIN ALKALOIDS AS IMMUNOSUPPRESSIVE COMPOUNDS Small organic molecules isolated from fungi represent a highly attractive compounds that have a potential for the modulation of specific physiological processes by affecting individual cellular pathways. A particularly interesting group of such fungal secondary metabolites is pseurotins, ergot-like alkaloids containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione core, that ...

Downloads

Downloads ZÁPIS Z JEDNÁNÍ KOMITÉTU /getfile/?mode=readfile&path=/cms/IUPAB/Zápis z jednání komitétu IUPAB 2016.docx /getfile/?mode=readfile&path=/cms/IUPAB/Zápis z jednání komitetu IUPAB 2017.docx VÝROČNÍ ZPRÁVA /getfile/?mode=readfile&path=/cms/IUPAB/Vyrocni zprava komitetu IUPAB 2016.pdf...

Nová strana

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Genetic engineering

 Plant transformation and genome editing facility      One of the most symptomatic feature of the post-genomic era is huge amount of uncharacterized sequencing data. On the other hand, recent advantages in reverse genetics encourages the scientific community to assess the functions of newly identified genes and improve our knowledge about molecular mechanisms that control biological processes in living organisms.      Our plant transformation and genome editing facility deals with Agro...

Organization structure

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Vědecký pracovník

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Projects

GAČR 19-09980S - Pro-inflammatory effects of LPS of cyanobacterial water bloom from freshwater reservoirs in the Czech Republic GAČR 17-18858S - Natural pseurotin alkaloids as significant immunotoxic contaminants GAČR 16-24949S - Importance of Toll-like receptors in intestinal epithelium response to cyanobacterial water bloom  CMST COST Action CM1201: Biomimetic Radical Chemistry      BMBS COST Action BM0806 Recent advances in histamine receptor H4R research GAČR 13-29358S (Jan Vitec...

Postdoctoral position in DNA replication & genome stability

  Postdoctoral position in DNA replication & genome stability The Department of Cell Biology & Epigenetics is looking for talented candidates who are interested in joining our department as postdoctoral fellows. The postdoctoral fellow will be affiliated with the laboratory of Dr. Hana Polasek-Sedlackova at the Department of Cell Biology and Epigenetics, Institute of Biophysics, Czech Academy of Sciences. The position is available from 1st March 2024 (or can be negotiated) Application ...

Projects

Ongoing projects National: Czech science foundation # P501/20-28029S     Relevance of duplicated promoter sequences for the function of plant 35S rDNA intergenic spacers. Investigator: Roman Matyášek   International: Czech science foundation / DFG (Germany) #20-14133J                    When sex may or may not happen – The impact of asymmetrical meiosis on the evolutionary fate of genes in polyploid roses. Investigators: Aleš Kovařík/Christiane M. Ritz      ...

Postdoktorand

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Právník

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Vědecký pracovník

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Teaching

Semester courses of DMBP Lecturer University Title of the lecture Viktor Brabec Palacký University, Olomouc Physical properties of nucleic acids Biophysics seminar 1 Structure of biomolecules Structure, properties and function of nucleic acids Molecular biology of mutagens Jana Kašpárková Palacký University, Olomouc Experimental methods in biophysics Molecular biophysics Molecular biology of mutagens Olga Nováková Masaryk University, Brno Selected topics in applied b...

Facebook

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Výzkumná pracovnice – postdoktorandka/ Výzkumný pracovník – postdoktorand

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Facebook page

https://www.facebook.com/biofyzs/...

Výzkumný/á pracovník/pracovnice

PhD position is available for highly motivated candidates   in the group Molecular DNA Complexes (Department of Cell Biology and Radiobiology) Institute of Biophysics, Czech Academy of Sciences, Brno, Czech Republic Start date: January 2020 or based on agreement We are long established team interested in the function and evolution of telomeres and telomerases in plants. We focus on telomerase genes, their regulation during plant growth and development with a special interest in DNA-protein, R...

POSTDOC position

POSTDOC position is available for highly motivated candidates  in the group Molecular DNA Complexes (Department of Cell Biology and Radiobiology) Institute of Biophysics, Czech Academy of Sciences, Brno, Czech Republic Start date: 1st January 2021 or earlier based on agreement We are long established team interested in the function and evolution of telomeres and telomerases in plants. We focus on telomerase genes, their regulation during plant growth and development with a special interest in ...

Výzkumný/á pracovník/pracovnice – postdoktorand/ka

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Strategie AV21 - program Qualitas

Strategie AV21 - program Qualitas2015 Černá hora2016 Brno2017 Lednice...

Výzkumný pracovník/pracovnice na pozici Ph.D. student

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PhD

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Doktorand/ka

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Doktorand/ka

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno  announces a selection procedure  Job title: PhD studentScientific department: Biophysical Chemistry and Molecular OncologyProject: GAČR- 22-21903S, Local DNA structures and their role in mutant p53 protein function in human tumours  Size of workload: 0.2Length of employment: 15. 2. 2024-31. 12. 2024 Minimum educational attainment: universityQualification level: R1Professional requirements: Completed ...

Ph.D. student

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Ph.D. student Scientific department: Department of Plant Developmental Genetics Project: TowArds Next GENeration Crops (OP JAK), CZ.02.01.01/00/22_008/0004581 Size of workload: 0,5Length of employment: until June 30, 2028 Minimum educational attainment: Completed master's degree in plant biotechnology, molecular biology or genetics.Qualification level: R1Professio...

Info about the department

Department of Molecular Epigenetics   Head: Aleš KovaříkScientific interests: Evolution of polyploid genomes Structure and expression of ribosomal RNA genes Organisation of satellite DNA repeats Animal rDNA database: www.animalrdnadatabase.com  ...

Selected results

VÝSLEDEK 1: NANOSCALE, 2018 Název výsledku: Zlomy DNA vytvořené urychlenými částice s podobným LET vykazují odlišnou komplexitu a opravitelnost: studie ohnisek γH2AX/53BP1 pomocí mikroskopie s vysokým rozlišením Title: Particles with similar LET values generate DNA breaks of different complexity and reparability: a high-resolution microscopy analysis of γH2AX/53BP1 foci Popis výsledku: Účinek ionizujícího záření na buňky odráží schopnost daného typu záření ioniz...

Postdoktorand/ka

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Co-operations

Co-operation   Prof. RNDr. Ivan Raška, DrSc. Institute of Cellular Biology and Pathology the First Faculty of Medicine, Charles University in Prague. Electron microscopy   Prof. Ohad Medalia Department of Biochemistry University of Zurich Winterthurerstr. 190 CH-8057 Zurich A new LA CSF project application   Mgr. Gabriela Lochmanová CEITEC Brno, Research group of prof. Zbyněk Zdráhal Kamenice 753/5 625 00 Brno...

OP JAK - Nové poznatky pro plodiny nové generace

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Specialista průtokové cytometrie a mikroskopie

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Doktorand/ka

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Foundations

In the field of electrochemical analysis of nucleic acids DBCMO possesses the world primacy thanks to the discovery of DNA electroactivity, made by prof. Emil Paleček in the late 1950‘s [Naturwiss. 45 (1958), 186-187, Nature 188 (1960) 656-657]. This discovery showed that it was possible to observe signals for adenine, cytosine and guanine using oscillographic polarography at dropping mercury electrode. Since then, the department has been intensively dealing with the study of the behavior ...

Vědecký pracovník

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Research profile

Electrochemistry and structure of nucleic acids We are interested in relations between primary (sequence), secondary (global and local conformation) and/or tertiary (superhelicity, topology) DNA structure and its interactions with charged surfaces of electrodes. These interactions are reflected in electrochemical (oxidation, reduction) and/or surface (adsorption, 2D condensation) activities of DNA and its components. Up to recently, electrochemical reduction of nucleic acids was feasible at merc...

Pedagogická činnost

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Doktorand/ka

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Group of DNA replication & genome stability

DNA replication & genome stability   Our lab is deeply interested in exploring the fundamental molecular mechanisms that ensure flawless DNA replication and maintain genome stability over multiple generations of dividing cells.   RESEARCH INTEREST: The development of the human body begins with a single cell, a fertilized egg, which divides about ten trillion times to form an adult. During each cell division, the entire genome is duplicated with ultra-high accuracy and subsequently inherit...

Valná hromada IUPAB

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Overview

Overview AB Attune: Flow cytometer equipped with two lasers (405 and 488nm) with separate optical paths and six detectors with high resolution (4.194.304 channels). The instrument uses a unique technology of acoustic focusing of the sample, which enables the user to analyse big sample volume in a short time (up to 1mL/min) and detect rare populations in your sample. The cytometer is controlled by the Attune Cytometric Software application, which is installed on a powerful workstation.   BD FAC...

Equipment

Equipment, technological expertise Hypoxbox Invivo2 400 (Baker Ruskinn) for cell culturing in hypoxia PCR thermocyclers: PTC-100 (MJ Research) and some others. Applications: FISH probe denaturation, genome fragment amplification, colony screening, plant genotyping, preparation and control of gene constructs 4D-Nucleofector (Lonza) – a transfection device for cells that can be transfected with difficulty Flowcytometer Muse Cell Analyzer (Merck Millipore): Analyses of cell numbers, cell cycle d...

Administrátor projektu

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Pedagogická činnost

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IUPAB General Assembly

https://www.ibp.cz/getfile/?mode=readfile&path=cms/Vyzkum/GA-Agenda-Congress2021.pdf...

Zvláštnosti v genomu koaly

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Teaching

Semester courses of DME Lecturer University Title of the lecture Aleš Kovařík Masarykova universita, Brno Special methods in microbiology Aleš Kovařík VUT Brno, Chemicko-technologická fakulta. The basics of modern bioinformatic methods ...

Pedagogická činnost

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Strengths and weaknesses of the current practice 2022-23

Strengths and weaknesses of the current practice Ethical and professional aspects Initial Phase 2021 Strengths: Freedom of research, respect to ethical principles as well as a professional responsibility. The Institute is well-recognized not only within the Czech Academy of Sciences but also worldwide. Ethics in scientific attitudes are promoted by a long tradition as well as strategic documents, stipulated at the IBP (https://www.; the Organization Code, the Career Code, the Guideline on the Pr...

Group of Jan Víteček

Jan Víteček, Mgr., Ph.D. Eva Šafaříková, Mgr. Marek Černík, Mgr. Sandra Thalerová, Mgr. Veronika Schildová, Bc. Patrícia Kittová, Bc. Michaela Pešková, Bc.   Organic electronics in biological applications Acute cardiotoxicity is a serious problem in modern drug development. A cell-based biosensor can reveal drug candidates, showing acute cardiotoxicity before they enter the animal testing phase. The option of organic semiconductors enables us to develop a low-cost disposable sen...

Preludium o sopkách, bombardování Země a formamidu

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Hardware

HardwareThe laboratory is presently equipped with several computer clusters of different architecture for a wide range of MD and QMapplications. The newest computer cluster cloud consists of four separate units. The first cluster is composed of 36 nodes with total number of 432 1.9 GHz E5-2420 Xeon cores with 0.8 TB of memory. Second unit dedicated for memory-demanding jobs comprises 12 nodes with 144 1.9 GHz E5-2420 Xeon CPU cores, each one having 96 GB of RAM memory. The third one is a GPU clu...

Contacts

Contact: Institute of Biophysics of the CAS, v. v. i.Královopolská 135612 00 BrnoCzech Republic Telephon: +420 - 541 517 111 E-mail: ibp@ibp.cz ...

DNA/RNA book

Computational Studies of RNA and DNA Springer Book Series - Volume 2 Edited by J. Šponer and F. Lankaš   Computational Studies of RNA and DNA includes, in an integrated way, modern computational studies of nucleic acids, ranging from advanced electronic structure quantum chemical calculations through explicit solvent molecular dynamics (MD) simulations up to mesoscopic modelling, with the main focus given to the MD field. It gives an equal emphasis to the leading methods and applications whil...

PhD program

PhD program, Postdocs, Students We offer high-quality PhD program and postdoctoral training in all areas of our research. We prefer to work with a smaller number of students based on an individual approach, contrasting the "massive student throughput system" common in many research laboratories. This allows the students to step by step develop their own research carrier. All our recent and current PhD students successfully published their work in high-impact international journals such as Journa...

Gender Equality Plan

Gender Equality Plan Since December 2021, the Institute of Biophysics (IBP) has been the holder of the HR Excellence in Research Award, which it received from the European Commission. The IBP creates a working, educational and cultural environment in which the equal rights and dignity of all employees are respected. Ensuring equal opportunities for women and men in the workplace is important to achieve this goal. To oversee the implementation of this plan, the HR Award will be given to the Steer...

Postdoctoral position – DNA damage repair and epigenetics

Postdoctoral position – DNA damage repair and epigenetics   The Department of Cell Biology & Epigenetics is looking for a postdoctoral fellow in the laboratory of Dr. Eva Bártová, the Department of Cell Biology and Epigenetics, Institute of Biophysics, Czech Academy of Sciences. The position is available from December 1st, 2022. Application deadline: September 15th, 2022 Department of Molecular Cytology and Cytometry is interested in the studies of the structures and processes in the ce...

Implementation phase

Implementation phase A) Implementation of the Action Plan (2022-2023) Implementation phase proceeded according to slightly modified Action Plan (here), where recommendations of EC (EC Consensus Report) were reflected. After 2 years of implementation we elaborated report on the realisation of the Action Plan for all actions (here), we prepared and analysed questionnairy on the implementation for our employees (here) and we submitted to EC an Internal Review according to the rules for HRAW (here)....

Collaboration

Collaboration J. Heyrovský Institute of Physical Chemistry, AS CRDepartment of Electrochemistry at the Nanoscale(Doc. Tomáš Navrátil) Faculty of Science, Charles University, Prague, Department of Analytical Chemistry UNESCO Laboratory of Environmental Electrochemistry(Prof. Jiří Barek, Dr. Karolina Schwarzová)   Faculty of Medicine and Dentistry, Palacký University Olomouc Department of Medical Chemistry and Biochemistry (Prof. Jan Vacek)   Masaryk Memorial Cancer Institute, BrnoRegio...

Conferences

Conferences Modern Electrochemical Methods series (annually held in Jetřichovice)         Individual books of abstracts can be downloaded here: https://www.bestservis.eu/en/past/   "Electrochemistry of Nucleic Acids and Proteins. New Tools for Biotechnologies".Brno, June 19-22, 2008. Satellite symposium to the ESEAC 2008 meeting.Photos from the conference (gallery,photos.zip)   Conference on Bioelectrochemistry and Bioelectronics of Macromolecules held on the occasion of the 70th...

Ph.D. student

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Ph.D. studentScientific department: Immune system biophysicsProject: MEDITECH CZ.02.01.01/00/23_021/0009171 Size of workload: 0.1 FTELength of employment: 1. 4. 2025-31. 12. 2028 Minimum educational attainment: Master of Science/Engineer with focus on biology or biochemistryQualification level: V2Professional requirements: experience with in vitro vascular models...

Supervisory Board

Supervisory Board of the Institute Chairman: prof. Ing. Luboš Náhlík, Ph.D. (Academy Council Czech Acad Sci) Vice-Chairman: Mgr. Vojtěch Novohradský, Ph.D. (Czech Acad Sci, Inst Biophys) Members: prof. RNDr. Jiří Doškař, CSc. (MUNI SCI)doc. RNDr. Pavel Matula, Ph.D. (MUNI FI)Ing. Ilona Müllerová, DrSc. (Czech Acad Sci, Inst Sci Instruments)prof. RNDr. Renata Veselská, Ph.D., M.Sc. (MUNI SCI) Secretary: Hana Křivánková, DiS...

Department News

2026 Prof. Eva Bártová, director of the Institute of Biophysics, has been elected as a member of the Scientific Council of the Faculty of Science at Masaryk University in Brno.   We present the methodological capabilities of our department, which cover a wide range of modern approaches as well as experimental and theoretical techniques. Our workplace is equipped with the expertise and infrastructure that enable the implementation of interdisciplinary research, from basic analytical me...

Researcher

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Position: ResearcherScientific Department: Department of Biophysics of the Immune System Size of working time: 0.5Length of employment: 1/1/2024-31/12/2025 Minimum educational attainment: PhD degree or its equivalentQualification level: V3 (R1)Professional requirements: certificate enabling independent work with laboratory animals; knowledge of performing experimental model...

Open Data and IT Network Rules

Open Data and IT Network Rules The establishment of scientific repositories in the Czech Republic was created on the basis of the "Action Plan for the Implementation of the National Strategy of Open Access to Scientific Information for 2017-2020", which was approved by the Government of the Czech Republic on 29 April 2019. Scientific information mean the results of science and research; it most often includes scientific publications, and their research data (data obtained during research, which ...

Teaching

Teaching Courses provided at the Faculty of Science, Masaryk University, Brno   Bi1033      Introduction to the study of Experimental Biology of Animals and Immunology                  (Úvod do studio specializace Experimentální biologie živočichů a imunologie) Bi1010      Biology of animal cell (Biologie živočišné buňky) Bi8110      Mechanisms of carcinogenesis (Mechanismy karcinogeneze) Bi6871      Health risks (Zdravotní rizika) Bi5599      A...

EDUROAM

  At the IBP AS CR there is available the access to EDUROAM (wiki, www.eduroam.org) network. The eduroam network enables transparent interconnection of academic computer networks. End users usually connect their terminals (notebook, PDA, WiFi phone) by wireless network (WiFi) but connection is also possible by wire. The user with an account in the eduroam network can get network connectivity enywhere, where the eduroam network is accessible - academic institutions in Europe, Asia-Pacific an...

Seeing is believing: Visualization of DNA replication machinery in living cells

Seeing is believing: Visualization of DNA replication machinery in living cells DNA replication is a fundamental process in every living organism. Precise regulation of genome duplication is absolutely critical for the fitness and survival of the organism as errors in DNA replication can lead to genome instability and the development of serious diseases such as cancer. Decades of beautiful work have provided new insights into the assembly, activation, and function of the replication fork, a basi...

PhD student

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: PhD studentScientific department: Department of Biophysical Chemistry and Molecular OncologyProject: 21-46325L (Czech Science Foundation) - Development of a sensitive and selective electrochemical genosensor for on-site detection of Citrus Bark Cracking Viroid (CBCVd) Size of workload: 0.3Length of employment: 15. 2. 2024 – 31. 12. 2024 Minimum educational attai...

Actions 2022-2023

Actions Action 1. Support of mobility, particularly, for PhD students employed at the IBP – a career improvement. A new institutional regulation will be established.  Action 2.  Recruitment tool - the external part containing job advertisements Action 3.  Translation of all internal rules into English.  Action 4.  Evaluation of departments (bibliometric analyses of scientific results). Evaluation of departments and their leader is performed using two independent systems. Act...

Research and development specialist

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Research and development specialistScientific department: Department of CytokineticsProject: CSF 24-10086S, The impact of polycyclic aromatic hydrocarbons on cellular processes linked with stress signaling and deregulation of metabolism Size of workload: 0.7Length of employment: until December 31, 2024 Minimum educational attainment: completed master's degree in b...

Doktorand2

Institute of Biophysics of the Czech Academy of Sciences Královopolská 135, 612 65 Brno, Czech Republic  offers a position  PhD student (R1), part-time with 0.4 workload – 16 h/week  at the Department of Biophysics of the Nucleic Acids for the project focusing on the unusual secondary structures of nucleic acids and their interactions with proteins and small-molecule ligands. Requirements: Student of a doctoral programme in Biophysics, Biochemistry, Chemistry or Molecular Biology at any ...

Rada Komercializace

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Projects

ProjectsGA ČR 202-04-0907High-resolution cytometry of living cells. (2004 - 2006) AS ČR 1QS500040508Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission. (2005 - 2009)GA AS ČR A1065203The use of multiple optical tweezers to controlled manipulation and rotation of micro objects. (2002 - 2006)GA AS CR A5004306Structure of human genome. (2004 - 2008)ME, COST 1P050C084Dynamic structure and function of the cell nucleus after irradiation. (2005 - 2007)IGA MH CR 1...

Implementation/Embedding the HRS4R process 2022-2023

Implementation/Embedding the HRS4R process General overview of the implementation process: (max. 1000 words)       The implementation process started with a great interest from both our Working Group, Screening Committee and Director of the Institute. The employees of the Institute of Biophysics had a good understanding and appreciation of the HRS4R activity keeping in mind the Gap Analysis and significance of the HRS4R process.        Our aim to consolidate the position of a national as ...

Open Data

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Finanční účetní

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Info about the department

The Department of Biophysics of Immune System is focused on molecular mechanisms regulating complex immune responses under both physiological and disease states including inflammation, infection and tissue injury.   Deregulation of immune response is the underlying cause precipitating the development of a wide range of pathologies such as cardiovascular diseases and diabetes, and many others. Therefore, improving understanding of the molecular mechanisms involved in the development of these ...

Info about the department

Department of Cell Biology and Radiobiology (DCBR) Head: Falk Martin, RNDr., Ph.D. (falk@ibp.cz; +420-728084060) Research profile DCBR In the Department of Cell Biology & Radiobiology, we investigate a broad scale of questions associated with structure and function of chromatin and DNA–molecular complexes in humans and plants. We are mostly interested in the principles of chromatin organization in nuclei of eukaryotic cells and relationships between chromatin architecture and function upon...

Professional staff - Researcher

Institute of Biophysics of the Czech Academy of Sciences announces Position: Professional staff - Researcher (R1) The Department Biophysics of the Immune System    Basic information: Position: Professional staff - Researcher Working place: The Department Biophysics of the Immune System A fully funded position with competitive salary in a well-established laboratory Full-time job – 1.0 full time equivalent The successful candidate can start immediately, the expected starting date is 1. 8. 20...

2018

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Národní

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Mezinárodní

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3D laboratory tour

http://ibp.pano3d.eu/?fbclid=IwAR157_drssRT2bIa_YawhF0EkCbMcbSMSYMYuT8wFP9XLqCE5dki-fZ1tFA...

PhD. student

PhD. student For the project team of Eva Sýkorová and Jiří Fajkus, dealing with plant telomere biology and telomerase characterization, we are looking for 1-2 PhD students for the period 1/7/2023-31/12/2023. Immediate start (as of July 1, 2023) is a requirement. It is a joint project of BFÚ AV ČR, v. v. i., and CEITEC MU. The work will therefore include activities at both sites and provides access to equipment at both participating institutions. Requirements: Completed MSc. education in t...

Info about the department

Department of Biophysical Chemistry and Molecular Oncology The Department of biophysical chemistry and molecular oncology (DBCMO) studies nucleic acids (NA), proteins and other biologically important molecules in solutions and at surfaces using a wide range of biophysical and bioanalytical techniques. It is engaged in electrochemical analysis of NA and proteins, including studies of their structure, interactions or labeling and develops novel materials and approaches for electrochemical analys...

Smlouvy o spolupráci

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Info about the department

Department of Cell Biology and Epigenetics (DCBE)  ...

Teaching

Semester courses of DCBE Lecturer University Title of the lecture Eva Bártová Masaryk University, Brno PřF:Bi8141 Molecular Physiology of Genom Pavel Veverka Masaryk University, Brno PřF:ILLU01 Illustration in science – attractive and comprehensive graphic visualization in research and educati PřF:C7235 Fluorescence methods in life sciences - excercise Tomáš Brom Masaryk University, Brno PřF:ILLU01 Illustration in science – attractive and comprehensive graphic vi...

National projects

Summary of national projects: From conformation to biological functions of HP1 protein Project ID: 18-07384S (standard project) Project Provider: GA ČR (Czech Science Foundation) Project Duration: 2018 - 2020 Principal Investigator: assoc. prof. RNDr. Stanislav Kozubek, DrSc. Project objectives: During cell differentiation and DNA repair processes, changes in post-translation modifications and conformation properties of heterochromatin protein 1 (HP1) are expected. These changes, determined by ...

Cooperation

Cooperation International Kirchhoff Institute für Physik, Heidelberg, Germany (Prof. Michael Hausmann) University Paris Sud / ISMO, Paris, France (Assoc. Prof. Sandrine Lacombe) European Institute of Oncology, Milano, Italy (Prof. Pier Giuseppe Pelicci) Joint Institute for Nuclear Research (JINR), Dubna, Russia (Accad. Prof. Evgeny Krasavin) - Terminated due to Russian aggression against Ukraine Department of Otorhinolaryngology, Universitätsklinikum Essen, University of Duisburg-Essen, Germa...

Postdoktorand/ka

POSTDOC position is available in the group Molecular DNA Complexes (Department of Cell Biology and Radiobiology), Institute of Biophysics, Czech Academy of Sciences Brno, Czech Republic We are established research team interested in the function and evolution of telomere and telomerase in plants. We focus on telomerase function during plant growth and vegetative development as well as on telomerase interactions in vivo and in vitro to establish working models. The successful candidates will join...

Eduard Kejnovský

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Researcher

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Position: ResearcherScientific Department: Department of Biophysics of the Immune System  Size of working time: 0.7Length of employment: 1/1/2024-31/12/2025 Minimum educational attainment: MSc degree or its equivalentQualification level: V1 (R1)Professional requirements: knowledge of enzymatic assays for screening of adenylyl cyclase activity modulation; knowledge of perf...

PhD POSITION IN CANCER BIOLOGY

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Members

Members Chair Assoc. Prof. RNDr. Eva Bártová, Ph.D.Institute of Biophysics of the CAS, v. v. i.Královopolská 135, 612 65 Brno, Czech Republicmailto:bartova@ibp.cz Deputy Chair Prof. RNDr. Vojtěch Mornstein, CSc.Faculty of Medicine, Masaryk UniversityKamenice 753/5, 625 00 Brno, Czech Republic Secretary  Mgr. Denisa Komůrková, Ph.D.Institute of Biophysics of the CAS, v. v. i.Královopolská 135, 612 65 Brno, Czech Republicmailto:komurkova@ibp.cz   Members Prof. RNDr. Viktor Brabec, Dr...

Network and Computers

We are sorry, but this text is only in czech language. Network and Computers IP adresy přidělené BFÚ AV ČR v Brně: 195.178.68.1 - 195.178.69.255, 147.231.203.1-255Ochrana elektronické pošty na serverech BFÚ před viry a zneužíváním e-mailu spammery. Pravidla provozu elektronické pošty BFÚ (.pdf)Pravidla provozu počítačové sítě BFÚ (.pdf)Pravidla správy sítě BFÚ (.pdf)Potvrzení o seznámení s pravidly provozu počítačové sítě Biofyzikálního ústavu AV ČR (...

Lab Techniques

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Teaching

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Vědecký pracovník

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Staff

Head of department Lukáš Kubala, doc., Mgr., Ph.D. (kubalal@ibp.cz) ORCID: https://orcid.org/0000-0002-7729-7338 ResearcherID: http://www.researcherid.com/rid/H-6329-2014 Publons: https://publons.com/a/259373 https://www.researchgate.net/profile/Lukas_Kubala   Group leaders  Gabriela Ambrožová, Mgr., Ph.D. (ambrozova@ibp.cz) ResearcherID: http://www.researcherid.com/rid/H-1891-2014 ORCID: https://orcid.org/0000-0002-8172-9746   Lenka Šindlerová, RNDr., Ph.D. (sindler@ibp.cz) ResearcherI...

Meet Sedlackova lab

Meet Sedlackova lab   Celebrating the 1st anniversary of the lab – February 2023. Holi in Sedlackova lab – March 2023. X-mas time – December 2022. Cell culture lab, ScanR microscope in High-content imaging lab, benches in the Core cell biology lab....

Národní projekty

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Info about the department

Department of Molecular Biophysics and Pharmacology   Head: Mgr. Vojtěch Novohradský, Ph.D.Scientific interests: Molecular and cellular mechanisms of action of anticancer and antimicrobial metallodrugs   The main research objective of the Department is to increase knowledge and understanding of the mechanisms of biological (antitumor and antibiotic) action of metallodrugs and to use this enhanced knowledge to develop new classes of metallodrugs with truly novel mechanisms of act...

ISAB MEMBERS

ISAB MEMBERS Tom Misteli, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, USABen Luisi, University of Cambridge, United KingdomElena Ferapontova, Aarhus University of Copenhagen, DenmarkMary Anne O'Connell, CEITEC MU, Brno, Czech RepublicJiří Forejt, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech RepublicGiovanni Natile, University of Bari, Aldo Moro, ItalyEran Meshorer, The Hebrew University of Jerusalem, Israel...

ERA fellowship

Regulation of DNA replication during normal development and tumorigenesis ABSTRACT: The development of the human body begins with a single cell of a fertilized egg, which must accurately replicate the entire DNA material and divide it between two daughter cells. These fundamental cellular processes, DNA replication, and cell division are constantly repeated until the generation of ten trillion cells that form the human adult body. How the cell regulates DNA replication to achieve ultra-high acc...

Research Associate Position

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Research Associate PositionScientific department: Department of Biophysics of Immune SystemProject: EXIT & SIT; EX VIVO TISSUE MODELS FOR SMALL INTESTINE TISSUE, 25-17718S, GACR Size of workload: 0.5Length of employment: till 31. 7. 2029 Minimum educational attainment: University DegreeQualification level: R1Expertise and qualifications: Master's degree in ce...

PhD Position in Radiation Biophysics for MSCA-DN “MS-RADAM”

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Skupina Replikace DNA a stability genomu (Sedlackova lab)

DNA replication & genome stability   Our lab is deeply interested in exploring the fundamental molecular mechanisms that ensure flawless DNA replication and maintain genome stability over multiple generations of dividing cells.   RESEARCH INTEREST: The development of the human body begins with a single cell, a fertilized egg, which divides about ten trillion times to form an adult. During each cell division, the entire genome is duplicated with ultra-high accuracy and subsequently inherit...

Meet Sedlackova lab

Current lab members. Celebrating the 2nd anniversary of the lab – February 2024. Hosting lecture of Dr. Jan Benada and Mendel Museum visit – May 2023. Holi in Sedlackova lab – March 2023. X-mas time – December 2022. Researchers' Night (October 2023) & discussion during the labmeeting (January 2024). Discussion during IBP career day (November 2023) and X-mas time (December 2023).  Cell culture lab, ScanR microscope in High-content imaging lab, benches in the Core cell biolog...

Department website

https://lc.ibp.cz/...

Teaching-old

Přehled semestrálních přednášek DPDGPřednášejícíUniverzitaNázev sem. přednáškyBoris VyskotUniverzita Karlova, PrahaPokroky v molekulární biologii pro doktorandy biomedicínyBoris VyskotMasarykova univerzita, BrnoVývojová genetikaOdborný seminář v angličtině (jarní a podzimní semestr)Eduard KejnovskýRoman HobzaMasarykova univerzita, BrnoEvolučn&...

INKUBATOR - Epigenetics of telomeres

Epigenetics of telomeres laboratory director Mgr. Pavel Veverka, Ph.D. postdoctoral researcher Mgr. Tomáš Brom, Ph.D. laboratory technician Bc. Tereza Paříková GRANT: Transcriptional regulation of Epstein–Barr oncovirus – biophysical implications for Rta-targeted therapy (Czech Science Foundation, grant, grant GA23-05241S), co-investigator at the Institute of Biophysics: Pavel Veverka, Ph.D.   V rámci výzkumu nyní bádáme nad virem Epstein-Barrové (EBV), který způsobuj...

Meet Borna Markusic — Visiting PhD student in the Sedlackova lab

Meet Borna Markusic — Visiting PhD student in the Sedlackova lab Borna Markusic began his scientific journey by earning a Bachelor’s degree in Biochemistry at Saint Joseph University in Philadelphia, USA. There, he secured two scholarships for his early research and received the “Scholastic Achievement” award from the American Chemical Society (ACS) in recognition of his academic excellence. After completing his undergraduate studies, Borna returned to Europe to pursue a PhD at the Inter...

National Projects

AhR Ligands as Regulators of Anti-Tumor Immunity in Melanoma Provider: CAS/IBP Academy of the Future Program Years: 2026 Investigator: Gabriela Ambrožová MEDITECH - Center for Multidisciplinary Research in Cardiovascular Medicine Project ID code: CZ.02.01.01/00/23_021/0009171 Provider: Ministry of Education Youth and Sports (OP JAK projects) Years: 2025 - 2028 Investigator: Jan Víteček   EXIT & SIT; Ex vivo tissue models for small intestine tissue  Project ID code: GACR 25-17718S Pro...

Management of the Institute

Management of the Institute Director Prof. RNDr. Eva Bártová, Ph.D., DSc.Phone: +420 - 541 517 141 (501)bartova@ibp.cz Deputy Director RNDr. Aleš Kovařík, CSc.Phone: +420 - 541 517 178kovarik@ibp.cz Head of Institute Board RNDr. Aleš Kovařík, CSc.Phone: +420 - 541 517 178kovarik@ibp.cz Head of Economic Administration Ing. Robert UlrichPhone: +420 - 541 517 131ulrich@ibp.cz Head of Technical Administration JUDr. Pavel VacekPhone: +420 - 541 517 287pavel.vacek@ibp.cz PR manager Assoc. P...

Nová strana - doplnit

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Sedlackova lab news

WORKSHOP INVITATION: IBP career day: Per Aspera Ad Astra 2024 Our lab is the main organizer of IBP career day: Per Aspera Ad Astra 2024. The career day is focused on future career possibilities in the academic and industrial spheres. During the event, four outstanding scientists will share stories of their scientific journeys and will lead popular round table discussions on various topics. We look forward to meeting you! More information here. Registration link here. October 2024 NEW PREPRI...

Sedlackova lab news

WORKSHOP INVITATION: IBP career day: Per Aspera Ad Astra 2024 Our lab is the main organizer of IBP career day: Per Aspera Ad Astra 2024. The career day is focused on future career possibilities in the academic and industrial spheres. During the event, four outstanding scientists will share stories of their scientific journeys and will lead popular round table discussions on various topics. We look forward to meeting you! More information here. Registration link here. October 2024 NEW PREPRI...

OP JAK - Meditech - Centrum pro multidisciplinární výzkum v kardiovaskulární medicíně

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Meet Dr. Klara Janjic—a guest researcher & lecturer in the Sedlackova lab

Meet Dr. Klara Janjic—a guest researcher & lecturer in the Sedlackova lab Klara Janjic started her journey as a scientist with a Bachelor program in “Biomedicine and Biotechnology” at the University of Veterinary Medicine in Vienna, Austria. Afterward, she continued to study the Master's program “Molecular Medicine” at the University of Vienna, for which she performed her master's thesis at the University Clinic of Dentistry, Medical University of Vienna. In 2020, she completed her...

Info about the department

Department of Cytokinetics Head: prof. RNDr. Jan Vondráček, Ph.D. Deputy head: Assoc. prof. Karel Souček, Ph.D.Scientific interests here Open positions ...

Meet Sedlackova lab

Current lab members. Celebrating the 4th anniversary of the lab (February 2026) & Journal Club with Klara Janjic (2025). Cold Spring Harbor Eukaryotic DNA Replication & Genome Stability Meeting, USA - September 2025. Central European Genome Stability Meeting, Debrecen, Hungary - June 2025. Celebrating the 3rd anniversary of the lab – February 2025. Hosting ScanR workshop: Pushing the boundaries of high-content imaging – August 2024. Hosting ScanR workshop: Pushing the boundar...

The Czech Society for Analytical Cytometry

https://www.csac.cz/en...

INTER-EXCELLENCE II

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Mission of the Institution

Mission of the Institute of Biophysics AS CR Who we are? Scientists of the Institute of Biophysics AS CR (IBP) are talented and highly motivated specialists, conducting research of fundamental importance. According to the results of the latest evaluation performed by an international committee, IBP is one of the best research institutes in the Academy of Sciences of the Czech Republic. Each year IBP publishes around 100 original results in journals that ensure high standards of peer review. Thes...

Organisational-information 2024-26

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Seeing is believing: Visualization of DNA replication machinery in living cells

Seeing is believing: Visualization of DNA replication machinery in living cells DNA replication is a fundamental process in every living organism. Precise regulation of genome duplication is absolutely critical for the fitness and survival of the organism as errors in DNA replication can lead to genome instability and the development of serious diseases such as cancer. Decades of beautiful work have provided new insights into the assembly, activation, and function of the replication fork, a basi...

Doktorand/ka

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Doktorand/ka

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: PhD studentScientific department: Department of Biophysical Chemistry and Molecular OncologyProject: 21-46325L (Czech Science Foundation) - Development of a sensitive and selective electrochemical genosensor for on-site detection of Citrus Bark Cracking Viroid (CBCVd) Size of workload: 0.5Length of employment: 1. 9. 2023 – 31. 12. 2023 Minimum educational attain...

OP VVV - SYMBIT - Structural gymnastics of nucleic acids: from molecular principles through biological functions to therapeutictargets. Support of integrated research team

https://www.ibp.cz/opvvv/symbit/index_en.html...

Info about the department

Department of Plant Developmental Genetics   Head: Roman Hobza Genome Dynamics We focus on understanding the dynamics of plant genomes in the context of the reproductive strategies of individual species. Our goal is to uncover the role of transposable elements in the evolution and regulation of gene expression, replication, and the structure of individual chromosomes. In our research, we employ single-cell (chromosome) genomics and transcriptomics approaches, combined with sophisticated bioinfo...

About us

About us In 2018, the Czech Committee for Biophysics was administered by the Institute of Biophysics, Academy of Sciences of the Czech Republic and was renamed the Czech Biophysical Association. The members of the association are scientists of the Institute of Biophysics, as well as teachers and professors of universities in Prague, Brno, Olomouc and Hradec Králové. The members of the association participate in biophysics research and teaching, regularly participate in biophysical meetings, c...

Profiles of research groups

Group of Gabriela Ambrožová Group of Lukáš Kubala Group of Lenka Šindlerová Group of Ondřej Vašíček Group of Jan Víteček    ...

PhD student

Management of Biofyzikální ústav AV ČR, v. v. i., Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: PhD studentScientific department: Department of Structure and Dynamics of Nucleic AcidsProject: 23-05639S, Molecular dynamics simulations of RNA: from static structures to molecular ensembles, Czech Science Foundation Size of workload: 1.0Length of employment: until 31. 12. 2024 Minimum educational attainment: Master degree diplomaQualification level: V2Professio...

Strengths-and-weaknesses-of-the-current-practice 2024-26

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OP PIK - Fotovoltaický systém Biofyzikálního ústavu AV ČR, v. v. i.

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Meet Sedlackova lab

Current lab members. Celebrating the 2nd anniversary of the lab – February 2024. Hosting lecture of Dr. Jan Benada and Mendel Museum visit – May 2023. Holi in Sedlackova lab – March 2023. X-mas time – December 2022. Researchers' Night (October 2023) & discussion during the labmeeting (January 2024). Discussion during IBP career day (November 2023) and X-mas time (December 2023).  Cell culture lab, ScanR microscope in High-content imaging lab, benches in the Core cell biolog...

Doctoral student

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Doctoral studentScientific department: Molecular biophysics and pharmacology Size of workload: 0,1Length of employment: 1. 11. – 31. 12. 2023 Minimum educational attainment: UniversityQualification level: R1Professional requirements: graduated from the Master's studies of the Faculty of Science, majoring in biochemistry; doctoral student, majoring in biochemist...

Organisational information 2022-23

Organisational information Staff & Students Total researchers = staff, fellowship holders, bursary holders, PhD. students either full-time or part-time involved in research: 151Of whom are international (i.e. foreign nationality): 20Of whom are externally funded (i.e. for whom the organisation is host organisation):  0Of whom are women: 78Of whom are stage R3 or R4 = Researchers with a large degree of autonomy, typically holding the status of Principal Investigator or Professor: 68Of whom a...

Postdoctoral position

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Research Funding

Our work is supported by funding from the Czech Science Foundation Junior Star (grant no. 22-20303M), the European Union’s Horizon 2022 Widera Talent program (ERA grant agreement no. 101090292), EMBO Installation Grant (grant no. EMBO IG-5689-2024), Jihomoravske centrum pro mezinarodni mobilitu (JCMM) project scholarships for talented foreign students and internal IBP funding.      January 2024: Dr. Hana Polasek-Sedlackova receives a prestigious EMBO Installation Grant EMBO Ins...

Výzkumný pracovník

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno  announces a selection procedure  Position: ResearcherScientific Department: Department of Biophysics of the Immune System  Size of working time: 0.3Length of employment: 1/11/2023 – 31/12/2025 Minimum educational attainment: Master’s degree or its equivalentQualification level: V1Professional requirements: certificate enabling independent work with laboratory animals; knowledge of performing exper...

Head of Scientific Department

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Head of Scientific DepartmentScientific department: Molecular Biophysics and Pharmacology Size of workload: 1,0Length of employment: 3-5 years with the possibility of further extension Minimum educational attainment: university degree (min. PhD)Qualification level: min. V4 (R2-R4)Professional requirements: a university degree in biophysics, biochemistry, molecula...

Organisational-information 2024-26

Organisational information 2024-2026 Organisational information 2024 Staff & Students Total researchers = staff, fellowship holders, bursary holders, PhD. students either full-time or part-time involved in research: 151Of whom are international (i.e. foreign nationality): 20Of whom are externally funded (i.e. for whom the organisation is host organisation):  0Of whom are women: 78Of whom are stage R3 or R4 = Researchers with a large degree of autonomy, typically holding the status of Princi...

Researcher - PhD student

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno  announces a selection procedure  Job title: Researcher - PhD studentScientific department: Cell biology and epigenetics - laboratory for preparation of viral constructsProject: GA ČR 23-05241S, Transcriptional regulation of Epstein–Barr oncovirus – biophysical implications for Rta-targeted therapy  Size of workload: 0.6Length of employment: till 31. 12. 2025  Minimum educational attainment: Unive...

Seeing is believing: Visualization of DNA replication machinery in living cells

Seeing is believing: Visualization of DNA replication machinery in living cells DNA replication is a fundamental process in every living organism. Precise regulation of genome duplication is absolutely critical for the fitness and survival of the organism as errors in DNA replication can lead to genome instability and the development of serious diseases such as cancer. Decades of beautiful work have provided new insights into the assembly, activation, and function of the replication fork, a basi...

ERA fellowship

Regulation of DNA replication during normal development and tumorigenesis ABSTRACT: The development of the human body begins with a single cell of a fertilized egg, which must accurately replicate the entire DNA material and divide it between two daughter cells. These fundamental cellular processes, DNA replication, and cell division are constantly repeated until the generation of ten trillion cells that form the human adult body. How the cell regulates DNA replication to achieve ultra-high acc...

Research Funding

Our work is supported by funding from the Czech Science Foundation Junior Star (grant no. 22-20303M), the European Union’s Horizon 2022 Widera Talent program (ERA grant agreement no. 101090292), EMBO Installation Grant (grant no. EMBO IG-5689-2024), Jihomoravske centrum pro mezinarodni mobilitu (JCMM) project scholarships for talented foreign students and internal IBP funding.      January 2024: Dr. Hana Polasek-Sedlackova receives a prestigious EMBO Installation Grant EMBO Ins...

ERA fellowship

Regulation of DNA replication during normal development and tumorigenesis ABSTRACT: The development of the human body begins with a single cell of a fertilized egg, which must accurately replicate the entire DNA material and divide it between two daughter cells. These fundamental cellular processes, DNA replication, and cell division are constantly repeated until the generation of ten trillion cells that form the human adult body. How the cell regulates DNA replication to achieve ultra-high acc...

Meet Dr. Klara Janjic—a guest researcher & lecturer in the Sedlackova lab

Meet Dr. Klara Janjic—a guest researcher & lecturer in the Sedlackova lab Klara Janjic started her journey as a scientist with a Bachelor program in “Biomedicine and Biotechnology” at the University of Veterinary Medicine in Vienna, Austria. Afterward, she continued to study the Master's program “Molecular Medicine” at the University of Vienna, for which she performed her master's thesis at the University Clinic of Dentistry, Medical University of Vienna. In 2020, she completed her...

Strengths and weaknesses of the current practice 2024-2026

Strengths and weaknesses of the current practice 2024-2026 Ethical and professional aspects Interim Assessment 2024 STRENGTHS: The research is focused to expanding knowledge for the good of mankind. Researchers have freedom in the selection of the subject of investigation, freedom of thought and expression, they use all methods available at the Institute. Good practice in research involves adoption of safe working practices and evaluation of the results using advanced scientific algorithms inclu...

Klíčový pracovník

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: Key ResearcherScientific department: Immune system biophysicsProject: MEDITECH CZ.02.01.01/00/23_021/0009171 Size of workload: 0.2 FTELength of employment: 1. 4. 2025-31. 12. 2028 Minimum educational attainment: Ph.D. degreeQualification level: R2/R3Professional requirements: scientific focus – demonstrated by a Ph.D. degree and a minimum of 10 years of researc...

Research Associate Position

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job Title: Research Associate PositionScientific Department: Cell Biology and Epigenetics Size of Workload: 1,0Length of Employment: till 31. 12. 2025 Minimum Educational Attainment: University DegreeQualification Level: V2 (R1) Professional Requirements: Study and labeling of mitochondria using confocal microscopy in live cells Epigenetic modifications of RNA and histones ...

Fagherazzi et al, 2025

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Confocal Microscopy

Confocal MicroscopyThere are 2 facilities in our Institute:Spinning disc confocal microscopy. Leica upright microscope, DMSTC motorized stage, Piezzo z-movement, MicroMax CCD camera, CSU-10 confocal unit, laser diodes (488, 562, and 714 nm) with AOTF. The equipment is controlled by the corresponding software using PC and software Acquarium developed in collaboration with MasarykUniversity.Laser scanning confocal microscopy (LSCM). In 2009, we established new Laboratoy Cellular Biophysics that in...

Teaching

 Overview of pedagogical activities of IBP departments in 2025  ...

Research Associate Position

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job Title: Research Associate PositionScientific Department: Department of Molecular biophysics and pharmacology Size of Workload: 0,5Length of Employment: till 31. 12. 2026 Minimum Educational Attainment: University DegreeQualification Level: R1 Professional Requirements: Tumor and molecular biology Biochemistry and pharmacology of drugs Technical Skills: Work with tissu...

Expanding the HaloTag toolbox: A new tool to fish out protein variants from live cells

Expanding the HaloTag toolbox: A new tool to fish out protein variants from live cells Proteins inside our cells are incredibly dynamic. They exist in different forms, change locations, and take on distinct roles depending on what the cell needs. To study these differences, scientists use technologies that help them ‚tag‘ proteins so they can be seen under a microscope or pulled out for closer examination. One of the most widely used systems for this is the HaloTag technology, which allows r...

Teaching

 EpigeneticsIntroduction to Developmental Biology and GeneticsEvolutionary GenomicsGenetical EngineeringPlant PhysiologySex Determination in PlantsMolecular Biology and GeneticsPokroky v molekulární biologii 2006Chromosomes and Sex DifferentiationPlant Transposable Elements Y Chromosome Evolution...

Collaboration

Collaborating scientists: Jaroslav DolezelLaboratory of Molecular Cytogenetics and Cytometry, Institute of Experimental Botany, Olomouc, Czech Republic Manuel JamilenaDepartment of Applied Biology, University od Almería, Almería, Spain Karel AngelisLaboratory of Repair Processes, Institute of Experimental Botany, Praha, Czech Republic Sarah R. GrantDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Jiri MacasLaboratory of Molecular Cytogenetics...

PhD Student

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno  announces a selection procedure  Job title: PhD StudentScientific department: DBSMOProject: LUAKR25078, Precision Control of Mitochondrial DNA via Structure–Sequence Integration for Medical Applications (Ministry of Education, Youth and Sports, Inter-Action programme)Size of workload: 0.2 FTELength of employment: until 30 September 2028 Minimum educational attainment: University degreeQualification le...

Keeping DNA Replication in Check: A New Mechanism Linking CRL4-DCAF12 and MCMBP

Keeping DNA Replication in Check: A New Mechanism Linking CRL4-DCAF12 and MCMBP Every time a cell divides, it must make an exact copy of its DNA. This process, called DNA replication, is tightly controlled to prevent errors that could lead to genome instability and disease. A key part of this process involves a group of proteins known as MCMs (minichromosome maintenance proteins), which form a complex that unwinds DNA and ensures that each segment is copied only once. Previous work from the Sedl...

Completed joint projects and collaboration of DCBE with universities

Completed joint projects and collaboration of DCBE with universities  LC535, Center of Basic Research: Structure of the cell nucleus in normal and pathological conditions, coordinator I. Raška, investigator, S. Kozubek (IBP AS CR), Kyra Michalova (FM UK), Michal Kozubek (FI MU), 2 joint publications LC06027, Center of Basic Research: Monoclonal gammopathy and multiple myeloma, coordinator R. Hájek, investigator E. Bártová (IBP AS CR) Other collaboration: P. Matula, analysis of confocal im...

International projects

International projects: Project: Czech-Norwegian networking on nuclear structure and function (Cze-No-Net) Project ID: 7F16012 Project Provider: MEYS (Fund for Bilateral Relations in Czech-Norwegian Research Programme CZ09) Project Duration: 2016 - 2017 Principal Investigator: assoc. prof. RNDr. Eva Bártová, Ph.D., DSc. (Department of Cell Biology and Epigenetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, CR) Project Partner: assoc. prof. Thomas M. Kutziger, Ph.D. (Instit...

Postdoc

Management of Biofyzikální ústav AV ČR, v. v. i.,Královopolská 2590/135, 612 00 Brno announces a selection procedure Job title: PostdocScientific department: Department of CytokineticsProject: CSF 26-20368S, “Unknown aspects of toxic effects of metabolites and oxygenated derivatives of polycyclic aromatic hydrocarbons linked with AhR action” Size of workload: 0.4Length of employment: until December 31, 2028  Minimum educational attainment: completed Ph.D.Qualification level: R1Profess...

Laboratory for Viral Constructs

Commercial services of the Laboratory for Viral Constructs The following biological agents of class 2 may be handled in the laboratory: Human cell lines eg. HEK, HeLa, Caov-3, HME, DU 145 Insect cell lines Sf9, Sf21, High Five, S2 Recombinant human immunodeficiency virus VSV-G pseudotyped retroviral and lentiviral vectors Baculovirus AcMNPV from the family Baculoviridae Modified Sendai viruses from the Paramyxoviridae group and derived SeV vectors The laboratory space consists of a preparation...

Aktuálně řešené projekty

Project Title: Fascinating Structure of Holliday Junction: The Crux of DNA Biophysics Studied by Molecular Dynamics Simulations Project Number: 25-16134S Principal Investigator: RNDr. Miroslav Krepl, Ph.D. Funding Agency: Czech Science Foundation (GA ČR) Project Duration: 2025–2027 Institution: Institute of Biophysics of the Czech Academy of Sciences, v.v.i. Project Description The project focuses on a detailed investigation of the so-called Holliday Junction (HJ), a unique four-stranded DNA...

Komerční služby

Commercial services   Commercial services associated with the Laboratory of Cellular Biophysics I. Available microscopes with climate chamber systems include the Leica TCS SP5 X and Leica TCS SP8 X SMD. The microscopes are equipped with a WLL laser, argon laser, and lasers with wavelengths of 355 nm and 405 nm. Services depend on capacity availability and access is subject to the internal booking system. A combination of the listed techniques is possible, as well as modification of their protoc...

Teaching

Miroslav Fojta: Masaryk University Brno, Faculty of Science: Chemical properties, structure and interactions of nucleic acids Brno University of Technology: Molecular biology   Václav Brázda: Brno University of Technology: Gene technology; Special molecular biotechnology   Marie Brázdová: Masaryk University, Faculty of Pharmacy: Biochemistry; Molecular biology; Methods of Molecular Biology...

Research profile

Electrochemistry and structure of nucleic acids (Head of the group: Miroslav Fojta) We are interested in relations between primary (sequence), secondary (global and local conformation) and/or tertiary (superhelicity, topology) DNA structure and its interactions with charged surfaces of electrodes. These interactions are reflected in electrochemical (oxidation, reduction) and/or surface (adsorption, 2D condensation) activities of DNA and its components. Up to recently, electrochemical reduction o...

Main page

Present events        https://www.nature.com/articles/s41586-025-10011-3#Sec44             Prof. Jiří Šponer gave his lecture at the conference of researchers of the Academic Award of the Academy of Sciences of the Czech Republic.   The lecture can be found at: https://www.youtube.com/live/86lgoiRDpVE The lecture starts at the 3rd hour, 8th minute.      We congratulate colleagues Hobza, Jedlička and Čegan on their extraordinary success, on the scientific paper publi...