Institute of Biophysics of the Czech Academy of Sciences

Bártová Eva, assoc. prof., RNDr., Ph.D., DSc.

Phone: +420541517140

Email: bartova@ibp.cz

Eva Bártová

Born 16^th January 1968 in Kaplice (Czech Republic) as Eva Musilová

Affiliation:

Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, CZ-61265 Brno, Czech Republic

Education, training and employment:

1991: graduated in Experimental Biology, Faculty of Sciences, Masaryk University Brno

1992-1995: Ph.D. study: Department of Animal Physiology, Faculty of Sciences, Masaryk University Brno. The experimental part of PhD study: Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Laboratory of Cytokinetics and Flow-cytometry.

1995-1997: Faculty of Medicine, Department of Pathophysiology, Masaryk University Brno.

1997-present: Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic,v.v.i., Brno, Czech Republic.

2010: Assoc. Prof. in Molecular Biology and Genetics, Masaryk University Brno, Czech Republic.

2015-2017: a part-time job at Institute of Cellular Biology and Pathology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic.

2016-present: Department leader: Department of Molecular Cytology and Cytometry (DMCC) at the Institute of Biophysics of the Czech Academy of Sciences, Brno. In 2021 DMCC was renamed to Department of Cell Biology and Epigenetics (DCBE)

2017-present: Director of the Institute of Biophysics of the Czech Academy of Sciences, Brno

2019: DSc. - Reseach Professor

2020: became EMBO member

Eva Bártová graduated from the Faculty of Science of Masaryk University (MU) in Brno. For two years, she was an assistant professor at the Faculty of Medicine, Masaryk University, Brno. In 1997 she was recruited as a young scientist at the Institute of Biophysics (IBP), wherein in 2005, she established her laboratory focused on epigenetics. In 2010, she became the associate professor of Genetics and Molecular Biology. Since 2016 she has been working as a department leader at IBP. In 2016-2017 she completed her internship at the 1st Medical Faculty of the Charles University in Prague, but in 2017, she became director of the Institute of Biophysics Czech Acad. Sci. In 2018, she received a bronze medal from Masaryk University (MU), which was awarded to the 100 best students who graduated during 100 years of MU duration. Eva Bártová defended her Research professor degree (DSc.) in 2019, and in 2020 she was elected as a member of the European Molecular Biological Society (EMBO member 2020), which is a prestigious award for scientists working in the field of molecular biology. So far, she has published more than 100 scientific papers; according to Google Scholar H-index is 29, and the number of citations is 3428. Under her leadership, more than 20 students defended their work, including eight dissertations. She works in two scientific councils of MU (the Faculty of Medicine and the Faculty of Sciences), she has been working in panels of the Czech Science Foundation (the highest grant authority in the Czech Republic) for several years, and annually she is an opponent of many students’ theses. Also, she is a member of the Molecular biology commissions for doctoral dissertations at MU; and she also serves as an ad-hoc reviewer in many scientific journals, including NAR or Epigenetics & Chromatin, etc. As the director of the Institute of Biophysics, she supports the work of parents with children, especially women in science. In this sense, she established a kid’s corner at the institute, and she supports a part-time job for parents with small children. Also, she works for the Strategy AV21, an activity of the Czech Academy of Sciences. The main scientific focus of Eva Bártová’s work concerns epigenetics and DNA repair; the most important discovery is the description of the function of OCT4 protein in DNA repair processes in embryonic stem cells. Her team studies the structure and function of chromatin in tumor and embryonic stem cells and during cell differentiation. Her scientific team tries to optimize new modern approaches of high-resolution cytometry, especially the methodology of advanced confocal microscopy. The principles of advanced confocal microscopy and FISH technique Eva studied, in a frame of EU project 3D genome (coordinated by prof. Roel van Driel, Netherlands), and during her short-time visits in the laboratory of prof. Christoph Cremer (Heidelberg, Germany), a founder of 4pi super-resolution microscopy. Eva Bártová is (was) PI of several national projects (approximately ten Czech projects), the prestigious EU project, Marie Curie, and two projects supported by Norwegian funds. In the case of international projects, during three years, she coordinated the work of Czech-Polish and Russian scientists, and following three years, she supervised the Czech-Norwegian cooperation. She also guarantees the work of the Czech Biophysical Society, which cooperates with the International Union of Pure and Applied Biophysics (IUPAB). She is also annually invited as a speaker at international conferences, such as the FEBS meeting in St. Petersburg (2013), Wilhelm Bernhard Workshop in Vienna (2015), Meeting on ES cell biology, Eilat, Israel (2017), or conference on the epigenetics of aging, Halle, Germany (2019), EMBO members’ meeting 2021 in Heidelberg, and others.

The list of scientific papers

1. Hofmanová J., Musilová E., Kozubík A. (1996). Suppression of human cancer cell proliferation by lipoxigenase inhibitors and gamma-radiation in vitro. Gen. Physiol. Biophys. 15, 317-331. IF=0.691. Hofmanová J., Musilová E., Kozubík A. (1996). Suppression of human cancer cell proliferation by lipoxigenase inhibitors and gamma-radiation in vitro. Gen. Physiol. Biophys. 15, 317-331. IF=0.69
2. Kozubík A., Hofmanova J., Dušek L., Musilová E. (1997) 5-lipoxigenase inhibitors potentiate effects of TGF-beta 1 on the differentiation of human leukemia HL-60 cells. J. Leuk. Biol., 62, 240-248. IF=4.22
3. Bártová E., Španová A., Janáková L., Bobková M., Rittich B. (1997) Apoptotic damage of DNA in human leukaemic HL-60 cells treated with C2-ceramide was detected after G1 blockade of the cell cycle. Physiol. Res., 46, 155-160. IF=1.14*3. Bártová E., Španová A., Janáková L., Bobková M., Rittich B. (1997) Apoptotic damage of DNA in human leukaemic HL-60 cells treated with C2-ceramide was detected after G1 blockade of the cell cycle. Physiol. Res., 46, 155-160. IF=1.14*
4. Kozubek M., Kozubek S., Lukášová E., Marečková A., Bártová E., Skalníková M., Jergová A. (1999) High-resolution cytometry: Automated 2-D and 3-D analysis of hybridization dots in interphase cell nuclei using multi-color FISH and CCD microscopy. Cytometry, 36, 279-293. IF=2.7
5. Lukášová E., Kozubek S., Kozubek M., Kroha V., Marečková A., Skalníková M., Bártová E., Šlotová J. (1999) Chromosomes participating in translocations typical of malignant haemoblastosis are also involved in exchange aberrations induced by fast neutrons. Radiat. Res., 151, 375-384. IF=3.23
6. Kozubek S., Lukášová E., Marečková A., Skalníková M., Kozubek M., Bártová E. , Kroha V., Krahulcová E., Šlotová J. (1999) The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9;22) translocations and in the pathogenesis of t(9;22) leukemias. Chromosoma, 108, 426-435. IF=2.71
7. Bártová E., Kozubek S., Kozubek M., Jirsová P., Lukášová E., Skalníková M., Buchníčková K. (2000) The influence of the cell cycle, differentiation and irradiation on the nuclear location of the abl, bcr and c-myc genes in human leukemic cells. Leukemia Research, 24, 233-241. IF=1.5*
8. Bártová E., Kozubek S., Kozubek M., Jirsová P., Lukášová E., Skalníková M., Cafourková A., Koutná I. (2000) Nuclear topography of the c-myc gene in human leukemic cells. Gene, 244, 1-11. IF=2.5*
9. Koutná I., Kozubek S., Žaloudík J. Kozubek M., Lukášová E., Matula P., Bártová E., Skalníková M., Cafourková A., Jirsová P. (2000) Topography of genetic loci in tissue samples: towards new diagnostic tool using interphase FISH and high-resolution image analysis techniques. Anal. Cell. Pathol. 20: (4) 173-185. IF=0.84
10. Skalníková M., Kozubek S., Lukášová E., Bártová E., Jirsová P., Cafourková A., Koutná I., Kozubek M. (2000) Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differentiation and after irradiation. Chromosome Res. 8: (6) 487-499. IF=1.73
11. Cafourková A., Lukášová E., Kozubek S., Kozubek M., Govorun R.D., Koutná I., Bártová E., Skalníková M., Jirsová P., Paseková R., Krasavin E.A. (2001) Exchange aberrations among 11 chromosomes of human lymphocytes induced by gamma-rays. Int. J. Radiat. Biol. 77: (4) 419-429. IF=2.36
12. Jirsová P., Kozubek S., Bártová E., Kozubek M., Lukášová E., Cafourková A., Koutná L., Skalníková M. (2001) Spatial distribution of selected genetic loci in nuclei of human leukemia cells after irradiation. Radiat. Res. 155: (2) 311-319. IF=2.45
13. Bártová E., Kozubek S., Jirsová P., Kozubek M., Lukášová E., Skalníková M., Cafourková A., Koutná I., Paseková R. (2001) Higher-order chromatin structure of human granulocytes. Chromosoma 110: 360-370. IF=3.29*
14. Kozubek M., Kozubek S., Lukášová E, Bártová E., Skalníková M., Matula P., Matula P., Jirsová P., Cafourková A., Koutná I. (2001) Combined confocal and wide-field high-resolution cytometry of fluorescent in situ hybridization-stained cells. Cytometry 45(1):1-12. IF=2.22
15. Bártová E., Kozubek S., Jirsová P., Kozubek M., Gajová H., Lukášová E., Skalníková M., Gaňová A., Koutná I., Hausmann M. (2002) Nuclear structure and gene activity in human differentiated cells. J. Struct. Biol. 139: 76-89. IF=4.2*
16. Kozubek S., Lukášová E., Jirsová P., Koutná I., Kozubek M., Gaňová A., Bártová E., Falk M., Paseková R.(2002) 3D structure of the human genome: order in randomness. Chromosoma 111: 321-331. IF=2.83
17. Taslerová R., Kozubek S., Lukášová E., Jirsová P., Bártová E., Kozubek M. (2002) Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells. Hum. Genet. 112(2):143-55. IF=3.43
18. Kozubek M., Skalníková M., Matula P., Bártová E., Rauch J., Neuhaus F., Eipel H., Hausmann M. (2002) Automated microaxial tomography of cell nuclei after specific labelling by fluorescence in situ hybridisation. Micron 33(7-8): 655-65. IF=1.54
19. Bártová E., Kozubek S., Gajová H., Jirsová P., Žlúvová J., Taslerová R., Koutná I., Kozubek M. (2003) Cytogenetics and cytology of retinoblastomas. J. Cancer Res. Clin. Oncol. 129(2):89-99. IF=2.16*
20. Bártová E., Jirsová P., Fojtová M, Souček K., Kozubek S. (2003) Chromosomal territory segmentation in apoptotic cells. Cell Mol Life Sci.60(5): 979-990. IF=4.99*
21. Galiová G., Bártová E., Kozubek S. (2004) Nuclear topography of beta-like globin gene cluster in IL-3-stimulated human leukemic K-562 cells. Blood Cells Mol. Dis. 33, 4-14. IF=2.55*
22. Bártová E., Harničarová A., Pacherník J., Kozubek S. (2005) Nuclear topography and expression of the BCR/ABL fusion gene and its protein level influenced by cell differentiation and RNA interference. Leuk Res. 29,901-913. IF=2.24*
23. Bártová E., Pacherník J., Harničarová A., Kovařík A., Kovaříková M., Hofmanová J., Skalníková M., Kozubek M., Kozubek S. (2005) Nuclear levels and patterns of histone H3 modifications and HP1 proteins after inhibition of histone deacetylases. J. Cell Sci. 118 (21), 5035-5046. IF= 6.91*
24. Bártová E., Kozubek S. (2006) Nuclear architecture in the light of gene expression and cell differentiation studies. Biol Cell. 98(6):323-36. Review. IF= 4.3*
25. Taslerová R., Kozubek S., Bártová E., Gajdušková P., Kodet R., Kozubek M.(2006) Localization of genetic elements of intact and derivative chromosome 11 and 22 territories in nuclei of Ewing sarcoma cells. J. Struct. Biol. 155(3):493-504. IF= 3.49
26. Harničarová A., Kozubek S., Pacherník J., Krejčí J., Bártová E. (2006) Distinct nuclear arrangement of active and inactive c-myc genes in control and differentiated colon carcinoma cells. Exp Cell Res. 312(20):4019-35. IF=3.77*
27. Skalníková M., Bártová E, Ulman V., Matula P., Svoboda D., Harničarová A., Kozubek M., Kozubek S. (2007) Distinct patterns of histone methylation and acetylation in human interphase nuclei. Physiol Res. 56(6):797-806. IF= 2.09*
28. Bártová E., Pacherník J., Kozubík A., Kozubek S. (2007) Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites. Histochem Cell Biol. 127(4):375-88. IF= 3.22*
29. Fojtova M., Piskala A., Votruba I., Otmar M., Bártová E., Kovařík A. (2007) Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer. Pharmacol. Res. 55(1):16-22. IF= 2.42
30. Koutná I., Krontorád P., Svoboda Z., Bártová E., Kozubek M., Kozubek S. (2007) New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways. Genomics 89(1):81-8. IF= 3.56
31. Kroupová J., Bártová E., Fojt L., Strasák L., Kozubek S., Vetterl V. (2007) Low-frequency magnetic field effect on cytoskeleton and chromatin. Bioelectrochemistry 70(1):96-100. IF= 1.88*
32. Bártová E., Krejčí J., Harnicarová A., Kozubek S. (2008) Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci. Differentiation. 76(1):24-32. IF= 3.75*
33. Bártová E., Harničarová A., Krejčí J., Strašák L. and Kozubek S. (2008) Single-cell c-myc gene expression in relationship to nuclear domains, accepted for publication in Chromosome Research, 6(2):325-43. IF=3.41*
34. Gabriela Galiová, Eva Bártová, Ivan Raška, Jana Krejčí and Stanislav Kozubek. (2008) Chromatin changes induced by lamin A/C deficiency and the HDAC inhibitor TSA. European Journal of Cell Biology, 87(5):291-303. IF=3.96*
35. Bártová E, Krejčí J, Harničarová A, Galiová G, Kozubek S. (2008) Histone Modifications and Nuclear Architecture: A Review. J Histochem Cytochem. 56(8):711-21. IF=2.82*
36. Krejčí J, Harničarová A, Kůrová J, Uhlířová R, Kozubek S, Legartová S, Hájek R, Bártová E. (2008) Nuclear organization of PML bodies in leukaemic and multiple myeloma cells. Leuk. Res., 32(12):1866-77. IF=2.39*
37. Bártová E, Galiová G, Krejčí J, Harničarová A, Strašák L, and Kozubek S. (2008) Epigenome and chromatin structure in human embryonic stem cells undergoing differentiation. Developmental Dynamics. 237(12):3690-702. IF=3.02*
38. Bártová E., Krejčí J., Hájek R., Harničarová A., Kozubek S. (2008) Chromatin Structure and Epigenetics of Tumour Cells: a Review. Cardiovascular and Haematological Disorders - Drug target, Mar;9(1):51-61. Review. IF=0*
39. Krejčí J., Uhlířová R., Galiová G., Kozubek S., Smogová J, Bártová E. (2009) Genome-wide reduction in H3K9 acetylation during human embryonic stem cell differentiation. Journal of Cellular Physiology, 219(3):677-87. IF=4.58.
40. Strašák L., Bártová E., Harničarová A., Galiová G., Krejčí J. nad Kozubek S. (2009) H3K9 acetylation influences radial chromatin positioning. Journal of Cellular Physiology, 220(1):91-101. IF=4.58*
41. Strašák L, Bártová E, Krejčí J, Fojt L, Vetterl V. (2009) Effects of ELF-EMF on brain proteins in mice. Electromagn Biol Med. 2009;28(1):96-104.IF=0.73
42. Epigenetics of multiple myeloma after treatment with cytostatics and gamma radiation. Krejčí J, Harničarová A, Štreitová D, Hájek R, Pour L, Kozubek S, Bártová E (2009) Leuk Res. 33(11):1490-8. IF=2.36*
43. Legartová S, Krejčí J, Harničarová A, Hájek R, Kozubek S, Bártová E. Nuclear topography of the 1q21 genomic region and Mcl-1 protein levels associated with pathophysiology of multiple myeloma. Neoplasma. 2009;56(5):404-13. IF=1.19*
44. Harničarová-Horáková A, Galiová G, Soňa L, Kozubek S, Matula P, Bártová E. (2010) Chromocentre integrity and epigenetic marks. J Struct Biol. 169(1):124-33. IF=3.50*
45. Uhlířová R, Harničarová Horáková A, Galiová G, Legartová S, Matula P, Fojtová M, Vařecha M, Amrichová J, Vondráček J, Kozubek S, Bártová E. (2010) SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement. J. Cellular Biochemistry, 109(5):915-26. IF=3.12*
46. Harničarová Horáková A., Bártová E., Galiová G., Uhlířová R., Matula P., Kozubek S. (2010) SUV39h-independent association of HP1β with fibrilarin-positive nucleolar region. Chromosoma, 119(3):227-41. IF=4.20*
47. Bártová E., Harničarová Horáková A., Uhlířová R., Raška I, Galiová G, Orlova D, Kozubek S. (2010) Structure and epigenetics of nucleoli in comparison with non-nucleolar compartments, J. Histochemistry & Cytochemistry, 58(5):391-403. IF=2.38*
48. Harničarová Horáková A, Bártová E, Kozubek S. (2010) Chromatin structure with respect to histone signature changes during cell differentiation. Cell Struct Funct. 35(1):31-44. Epub 2010 Apr 15. Review. IF=3.27*
49. Legartova S, Harnicarova-Horakova A, Bartova E, Hajek R, Pour L, Kozubek S. (2010)Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors. Neoplasma 57(5):482-7. IF=1.45*
50. Eva Bártová, Gabriela Galiová, Soňa Legartová, Lenka Stixová, Alžběta Jugová, Stanislav Kozubek. (2010) Genome instability in the context of chromatin structure and fragile sites. Critical Reviews in Eukaryotic Gene expression, 20(3):181-94. IF=4.11*
51. Bártová E, Stixová L, Galiová G, Horáková AH, Legartová S, Kozubek S. (2011) Mutant genetic background affects functional re-arrangement and kinetic properties of JMJD2B histone demethylase. J. Mol. Biol. 405(3):679-95. IF=4.01*
52. Darya Yu. Orlova, Eva Bártová , Valeri P. Maltsev, Stanislav Kozubek (2011) A non-fitting method employing a spatial sine window transform for inhomogeneous effective diffusion measurements by FRAP. Biophysical Journal, 100(2):507-16. IF=4.2252. Darya Yu. Orlova, Eva Bártová , Valeri P. Maltsev, Stanislav Kozubek (2011) A non-fitting method employing a spatial sine window transform for inhomogeneous effective diffusion measurements by FRAP. Biophysical Journal, 100(2):507-16. IF=4.22
53. Stixová L, Bártová E, Matula P, Daněk O, Legartová S, Kozubek S. (2011) Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin. Epigenetics and Chromatin 4:5. IF=4.73*
54. Jugova A, Sustackova G, Legartova S, Stixova L, Kozubek S, Bartova E. (2011) Effects of epigenetic-based anti-cancer drugs in leukemia and multiple myeloma cells. Cell Biol Int. 35(12):1195-203, IF=1.75*
55. Šustáčková G, Kozubek S, Stixová L, Legartová S, Matula P, Orlova D, Bártová E. (2011) Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. J Cell Physiol. 227(5):1838-50; IF=4.0*
56. Šustáčková G, Legartová S, Kozubek S, Stixová L, Pacherník J, Bártová E. (2011) Differentiation-Independent Fluctuation of Pluripotency-Related Transcription Factors and Other Epigenetic Markers in Embryonic Stem Cell Colonies. Stem Cells Dev. 21(5):710-20. IF=4.79*
57. Bártová E, Šustáčková G, Stixová L, Kozubek S, Legartová S, Foltánková V. (2011) Recruitment of Oct4 protein to UV-damaged chromatin in embryonic stem cells. PLoS One. 2011;6(12):e27281. IF=4.3.
58. FOLTÁNKOVÁ V., LEGARTOVÁ S., KOZUBEK S., BÁRTOVÁ E. (2012) Tumor-specific histone signature and DNA methylation in multiple myeloma and leukemia cells. Neoplasma. 59(4):450-62.
59. Orlova DY, Stixová L, Kozubek S, Gierman HJ, Sustáčková G, Chernyshev AV, Medvedev RN, Legartová S, Versteeg R, Matula P, Stoklasa R, Bártová E. (2012) Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells. J Cell Biochem. 113(11):3313-29. doi: 10.1002/jcb.24208.
60. Stixová L, Matula P, Kozubek S, Gombitová A, Cmarko D, Raška I, Bártová E. (2012) Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency. Biol Cell. 2012 Jul;104(7):418-32. doi: 10.1111/boc.201100053. Epub 2012 May 23.
61. Legartová S, Jugová A, Stixová L, Kozubek S, Fojtová M, Zdráhal Z, Lochmanová G, Bártová E. (2012) Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin. Biochimie. 2012 Sep 27. pii: S0300-9084(12)00387-2. doi: 10.1016/j.biochi.2012.09.027.
62. Šmigová J. Juda, Bártová E., Raška I. Dynamics of Polycomb chromatin domains under conditions of increased molecular crowding. Accepted in Biology of the Cell, 2013.
63. Legartová S., Stixová L., Strnad H., Kozubek S., Martinet N., Dekker FJ, Franek M., Bártová E. Basic nuclear processes affected by HAT and HDAC inhibitors. Epigenomics, 2013, 5(4):379-96.
64. Bártová E and Stixová L. Functional Consequences of Nuclear and Nucleolar Architecture. Kniha proteins of the Nucleolus, Editors: Danton H. O’Day and Andrew Catalano, Springer, 2013, ISBN 978-94-007-5818-6. doi: 10.1007/978-94-007-5818-6. Chapter in book.
65. Přikrylová T., Pacherník J., Kozubek S., Bártová E. Epigenetics and chromatin plasticity in embryonic stem cells. World Journal of Stem Cells, 5(3): 73-85. ISSN 1948-0210. doi: 10.4252/wjsc.v5.i3.73. review
66. Foltánková V, Legartová S, Kozubek S, Hofer M, Bártová E. DNA-damage response in chromatin of ribosomal genes and the surrounding genome. Gene. 2013, 15;522(2):156-67.
67. Foltánková V, Matula P, Sorokin D, Kozubek S, Bártová E. Hybrid detectors improved time-lapse confocal microscopy of PML and 53BP1 nuclear body colocalization in DNA lesions. Microsc Microanal. 2013, 19(2):360-9.
68. Juda P, Smigová J, Kováčik L, Bártová E, Raška I. Ultrastructure of cytoplasmic and nuclear inosine-5'-monophosphate dehydrogenase 2 "rods and rings" inclusions. J Histochem Cytochem. 2014 Oct;62(10):739-50.
69. Bártová E, Foltánková V, Legartová S, Sehnalová P, Sorokin DV, Suchánková J, Kozubek S.Coilin is rapidly recruited to UVA-induced DNA lesions and γ-radiation affects localized movement of Cajal bodies. Nucleus. 2014 May-Jun;5(3):460-8.
70. Krutá M, Seneklová M, Raška J, Salykin A, Zerzánková L, Pešl M, Bártová E, Franek M, Baumeisterová A, Košková S, Neelsen KJ, Hampl A, Dvořák P, Rotrekl V. Mutation Frequency Dynamics in HPRT Locus in Culture-Adapted Human Embryonic Stem Cells and Induced Pluripotent Stem Cells Correspond to Their Differentiated Counterparts. Stem Cells Dev. 2014 Oct 15;23(20):2443-54.70. Krutá M, Seneklová M, Raška J, Salykin A, Zerzánková L, Pešl M, Bártová E, Franek M, Baumeisterová A, Košková S, Neelsen KJ, Hampl A, Dvořák P, Rotrekl V. Mutation Frequency Dynamics in HPRT Locus in Culture-Adapted Human Embryonic Stem Cells and Induced Pluripotent Stem Cells Correspond to Their Differentiated Counterparts. Stem Cells Dev. 2014 Oct 15;23(20):2443-54.
71. Legartová S, Kozubek S, Franek M, Zdráhal Z, Lochmanová G, Martinet N, Bártová E.Cell differentiation along multiple pathways accompanied by changes in histone acetylation status. Biochem Cell Biol. 2014 Apr;92(2):85-93.
72. Sehnalová P, Legartová S, Cmarko D, Kozubek S, Bártová E. Recruitment of HP1β to UVA-induced DNA lesions is independent of radiation-induced changes in A-type lamins. Biol Cell. 2014 May;106(5):151-65.
73. Legartová S, Stixová L, Laur O, Kozubek S, Sehnalová P, Bártová E. Nuclear structures surrounding internal lamin invaginations. J Cell Biochem. 2014 Mar;115(3):476-87.
74. Stixová L, Sehnalová P, Legartová S, Suchánková J, Hrušková T, Kozubek S, Sorokin DV, Matula P, Raška I, Kovařík A, Fulneček J, Bártová E. HP1β-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs. Epigenetics Chromatin. 2014;7(1):39. doi:10.1186/1756-8935-7-39.
75. Stixová L, Hrušková T, Sehnalová P, Legartová S, Svidenská S, Kozubek S, Bártová E. Advanced microscopy techniques used for comparison of UVA- and γ-irradiation-induced DNA damage in the cell nucleus and nucleolus. Folia Biol (Praha). 2014;60 Suppl 1:76-84.
76. Sorokin DV, Suchánková J, Bártová E, Matula P. Visualizing stable features in live cell nucleus for evaluation of the cell global motion compensation. Folia Biol (Praha). 2014;60 Suppl 1:45-49.
77. Suchánková J, Legartová S, Sehnalová P, Kozubek S, Valente S, Labella D, Mai A, Eckerich C, Fackelmayer FO, Sorokin DV, Bártová E. PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage. Eur J Histochem. 2014;58(2):2389. doi:10.4081/ejh.2014.2389.
78. Suchánková J, Kozubek S, Legartová S, Sehnalová P, Küntziger T, Bártová E. Distinct kinetics of DNA repair protein accumulation at DNA lesions and cell cycle-dependent formation of γH2AX- and NBS1-positive repair foci. Biol Cell. 2015. doi:10.1111/boc.201500050.
79. Sorokin D V, Stixová L, Sehnalová P, Legartová S, Suchánková J, Šimara P, Kozubek, Matula P, Skalníková M, Raška I, Bártová E. Localized movement and morphology of UBF1-positive nucleolar regions are changed by γ-irradiation in G2 phase of the cell cycle. Nucleus. 2015;6(4):301-313. doi:10.1080/19491034.2015.1075111.
80. Legartová S, Sbardella G, Kozubek S, Bártová E. Ellagic Acid-Changed Epigenome of Ribosomal Genes and Condensed RPA194-Positive Regions of Nucleoli in Tumour Cells. Folia Biol (Praha). 2015;61(2):49-59.
81. Franek M, Legartová S, Suchánková J, Milite C, Castellano S, Sbardella G, Kozubek S, Bártová E. CARM1 modulators affect epigenome of stem cells and change morphology of nucleoli. Physiol Res. 2015.
82. Krejčí J, Stixová L, Pagáčová E, Legartová S, Kozubek S, Lochmanová G, Zdráhal Z, Sehnalová P, Dabrawolski S, Hejátko J, Bártová E. Post-Translational Modifications of Histones in Human Sperm. J Cell Biochem. 2015. doi:10.1002/jcb.25170.
83. Suchánková J, Kozubek S, Legartová S, Sehnalová P, Küntziger T, Bártová E. Distinct kinetics of DNA repair protein accumulation at DNA lesions and cell cycle-dependent formation of γH2AX- and NBS1-positive repair foci. Biol Cell. 2015. doi:10.1111/boc.201500050. IF=2.55*
84. Sorokin D V, Stixová L, Sehnalová P, Legartová S, Suchánková J, Šimara P, Kozubek, Matula P, Skalníková M, Raška I, Bártová E. Localized movement and morphology of UBF1-positive nucleolar regions are changed by γ-irradiation in G2 phase of the cell cycle. Nucleus. 2015;6(4):301-313. doi:10.1080/19491034.2015.1075111. IF=2.45*
85. Legartová S, Sbardella G, Kozubek S, Bártová E. Ellagic Acid-Changed Epigenome of Ribosomal Genes and Condensed RPA194-Positive Regions of Nucleoli in Tumour Cells. Folia Biol (Praha). 2015;61(2):49-59. IF=0.83*
86. Franek M, Legartová S, Suchánková J, Milite C, Castellano S, Sbardella G, Kozubek S, Bártová E. CARM1 modulators affect epigenome of stem cells and change morphology of nucleoli. Physiol Res. 2015. IF=1.64*
87. Krejčí J, Stixová L, Pagáčová E, Legartová S, Kozubek S, Lochmanová G, Zdráhal Z, Sehnalová P, Dabrawolski S, Hejátko J, Bártová E. Post-Translational Modifications of Histones in Human Sperm. J Cell Biochem. 2015. doi:10.1002/jcb.25170. IF=3.45*87. Krejčí J, Stixová L, Pagáčová E, Legartová S, Kozubek S, Lochmanová G, Zdráhal Z, Sehnalová P, Dabrawolski S, Hejátko J, Bártová E. Post-Translational Modifications of Histones in Human Sperm. J Cell Biochem. 2015. doi:10.1002/jcb.25170. IF=3.45*
88. Bártová E, Večeřa J, Krejčí J, Legartová S, Pacherník J, Kozubek S.The level and distribution pattern of HP1β in the embryonic brain correspond to those of H3K9me1/me2 but not of H3K9me3. Histochem Cell Biol. 2016. IF=2.78*
89. Franek M, Suchánková J, Sehnalová P, Krejčí J, Legartová S, Kozubek S, Večeřa J, Sorokin DV, Bártová E. Advanced Image Acquisition and Analytical Techniques for Studies of Living Cells and Tissue Sections. Microsc Microanal. 2016. IF=1.73*
90. Smirnov E, Hornáček M, Kováčik L, Mazel T, Schröfel A, Svidenská S, Skalníková M, Bartová E, Cmarko D, Raška I. Reproduction of the FC/DFC units in nucleoli. Nucleus. 2016;7(2):203-15. IF=2.45
91. Soňa Legartová, Petra Sehnalová, Barbora Malyšková, Thomas Küntziger, Philippe Collas, Dušan Cmarko, Ivan Raška, Dmitry V. Sorokin, Stanislav Kozubek and Eva Bártová. PML protein deficiency affects levels of 53BP1 protein and trajectory of 53BP1 positive DNA repair foci co-localizing with interchromatin granule-associated zones and nuclear speckles. Accepted for publication in Journal of Cellular Biochemistry, 2016; 117(11):2583-96. IF=3.45*
92. Legartová S, Sehnalová P, Malyšková B, Küntziger T, Collas P, Cmarko D, Raška I, Sorokin DV, Kozubek S, Bártová E. Cover Image, Volume 117, Number 11, November 2016. J Cell Biochem. 2016 Nov;117(11):i. doi: 10.1002/jcb.25671. IF=3.45*
93. Krejčí J, Legartová S, Bártová E. Neural Differentiation in HDAC1-Depleted Cells Is Accompanied by Coilin Downregulation and the Accumulation of Cajal Bodies in Nucleoli. Stem Cells Int. 2017;2017:1021240. doi: 10.1155/2017/1021240.
94. Večeřa J, Bártová E, Krejčí J, Legartová S, Komůrková D, Rudá-Kučerová J, Štark T, Dražanová E, Kašpárek T, Šulcová A, Dekker FJ, Szymanski W, Seiser C, Weitzer G, Mechoulam R, Micale V, Kozubek S. HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals. J Cell Physiol. 2017 Mar 16.
95. Bártová E, Malyšková B, Komůrková D, Legartová S, Suchánková J, Krejčí J, Kozubek S. Function of heterochromatin protein 1 during DNA repair. Protoplasma. 2017 May;254(3):1233-1240. doi: 10.1007/s00709-017-1090-3. Review.
96. Bártová E, Suchánková J, Legartová S, Malyšková B, Hornáček M, Skalníková M, Mašata M, Raška I, Kozubek S. PCNA is recruited to irradiated chromatin in late S-phase and is most pronounced in G2 phase of the cell cycle. Protoplasma. 2017 Jan 20. doi: 10.1007/s00709-017-1076-1.
97. Franek M, Kovaříková A, Bártová E, Kozubek S. Nucleolar Reorganization Upon Site-Specific Double-Strand Break Induction. J Histochem Cytochem. 2016 Nov;64(11):669-686. doi: 10.1369/0022155416668505.97. Franek M, Kovaříková A, Bártová E, Kozubek S. Nucleolar Reorganization Upon Site-Specific Double-Strand Break Induction. J Histochem Cytochem. 2016 Nov;64(11):669-686. doi: 10.1369/0022155416668505.
98. Suchánková J, Legartová S, Ručková E, Vojtěšek B, Kozubek S, Bártová E.Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants. Histochem Cell Biol. 2017 Apr 10. doi: 10.1007/s00418-017-1567-3.
99. Hornáček M, Kováčik L, Mazel T, Cmarko D, Bártová E, Raška I, Smirnov E. Fluctuations of pol I and fibrillarin contents of the nucleoli. Nucleus. 2017 Jun 16:1-12. doi: 10.1080/19491034.2017.1306160.
100. Legartová S, Suchánková J, Krejčí J, Kovaříková A, Bártová E. Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions. J Vis Exp. 2017 Nov 12;(129). doi: 10.3791/55999.100. Legartová S, Suchánková J, Krejčí J, Kovaříková A, Bártová E. Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions. J Vis Exp. 2017 Nov 12;(129). doi: 10.3791/55999.
101. Harikumar A, Edupuganti RR, Sorek M, Azad GK, Markoulaki S, Sehnalová P, Legartová S, Bártová E, Farkash-Amar S, Jaenisch R, Alon U, Meshorer E. An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells. Stem Cell Reports. 2017 Oct 10;9(4):1304-1314. doi: 10.1016/j.stemcr.2017.08.022. Epub 2017 Sep 28.
102. Legartová S, Suchánková J, Krejčí J, Kovaříková A, Bártová E Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions. J Vis Exp. 2017 Nov 12;(129). doi: 10.3791/55999.
103. Glazachev YI, Orlova DY, Řezníčková P, Bártová E. Effective scheme of photolysis of GFP in live cell as revealed with confocal fluorescence microscopy. Phys Biol. 2018 Mar 23;15(3):036008. doi: 10.1088/1478-3975/aab31e
104. Eva Bártová, Soňa Legartová, Jana Krejčí, Petra Řezníčková, Alena Kovaříková, Jana Suchánková, Radek Fedr, Evgeny Smirnov, Matúš Hornáček and Ivan Raška. Depletion of A-type lamins and Lap2α reduces 53BP1 accumulation at UV-induced DNA lesions and Lap2α protein is responsible for compactness of irradiated chromatin. Accepted for publication in J Cell Biochem. 2018.
105. Pokorná P, Krepl M, Bártová E, Šponer J. Role of Fine Structural Dynamics in Recognition of Histone H3 by HP1γ(CSD) Dimer and Ability of Force Fields to Describe Their Interaction Network. J Chem Theory Comput. 2019 Oct 8;15(10):5659-5673. doi: 10.1021/acs.jctc.9b00434. Epub 2019 Sep 18.105. Pokorná P, Krepl M, Bártová E, Šponer J. Role of Fine Structural Dynamics in Recognition of Histone H3 by HP1γ(CSD) Dimer and Ability of Force Fields to Describe Their Interaction Network. J Chem Theory Comput. 2019 Oct 8;15(10):5659-5673. doi: 10.1021/acs.jctc.9b00434. Epub 2019 Sep 18.
106. Bártová E, Legartová S, Dundr M, Suchánková J.A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair. Aging (Albany NY). 2019 Apr 17;11(8):2488-2511. doi: 10.18632/aging.101917.
107. Stixová L, Komůrková D, Svobodová Kovaříková A, Bártová E. UVA irradiation strengthened an interaction between UBF1/2 proteins and H4K20 di-/tri-methylation. Chromosome Res. 2019 Mar;27(1-2):41-55. doi: 10.1007/s10577-018-9596-x. Epub 2019 Jan
108. Svobodová Kovaříková A, Legartová S, Krejčí J, Bártová E. H3K9me3 and H4K20me3 represent the epigenetic landscape for 53BP1 binding to DNA lesions. Aging (Albany NY). 2018 Oct 11;10(10):2585-2605. doi: 10.18632/aging.101572.
109. Arcidiacono OA, Krejčí J, Suchánková J, Bártová E. Deacetylation of Histone H4 Accompanying Cardiomyogenesis is Weakened in HDAC1-Depleted ES Cells. Int J Mol Sci. 2018 Aug 16;19(8). pii: E2425. doi: 10.3390/ijms19082425.
110. Bártová E, Lochmanová G, Legartová S, Suchánková J, Fedr R, Krejčí J, Zdráhal Z.Irradiation by γ-rays reduces the level of H3S10 phosphorylation and weakens the G2 phase-dependent interaction between H3S10 phosphorylation and γH2AX. Biochimie. 2018 Nov;154:86-98. doi: 10.1016/j.biochi.2018.07.029. Epub 2018 Aug 8.
111. Legartová S, Lochmanová G, Zdráhal Z, Kozubek S, Šponer J, Krepl M, Pokorná P, Bártová E. DNA Damage Changes Distribution Pattern and Levels of HP1 Protein Isoforms in the Nucleolus and Increases Phosphorylation of HP1β-Ser88. Cells. 2019 Sep 17;8(9). pii: E1097. doi: 10.3390/cells8091097.
112. Svobodová Kovaříková A, Stixová L, Kovařík A, Komůrková D, Legartová S, Fagherazzi P, Bártová E. N6-Adenosine Methylation in RNA and a Reduced m3G/TMG Level in Non-Coding RNAs Appear at Microirradiation-Induced DNA Lesions. Cells. 2020 Feb 4;9(2). pii: E360. doi: 10.3390/cells9020360.
113. E Bártová, S Legartová, J Krejčí, OA Arcidiacono. Cell differentiation and aging accompanied by depletion of ACE2. protein. Aging (Albany NY) 12 (22), 22495, 2020113. E Bártová, S Legartová, J Krejčí, OA Arcidiacono. Cell differentiation and aging accompanied by depletion of ACE2. protein. Aging (Albany NY) 12 (22), 22495, 2020
114. V Ledvina, K Klepárník, S Legartová, E Bártová. A device for investigation of natural cell mobility and deformability Electrophoresis 41 (13-14), 1238-1244, 2020
115. A Svobodová Kovaříková, E Bártová, A Kovařík, E Lukášová. Spatiotemporal mislocalization of nuclear embrane-associated proteins in γ-irradiation-induced senescent cells. Cells 9 (4), 999, 2020
116. A Svobodová Kovaříková, L Stixová, A Kovařík, D Komůrková, ...Bártová E.116. A Svobodová Kovaříková, L Stixová, A Kovařík, D Komůrková, ...Bártová E.N6-Adenosine Methylation in RNA and a reduced m3G/TMG level in non-coding RNAs appear at microirradiation-induced DNA lesions. Cells 9 (2), 360, 2020
117. OA Arcidiacono, J Krejčí, E Bártová. The distinct function and localization of METTL3/METTL14 and METTL16 enzymes in cardiomyocytes. International Journal of Molecular Sciences 21 (21), 8139, 2020.
118. OA Arcidiacono, J Krejčí, S Legartová, L Stixova, E Bártová. Epigenetic processes and DNA repair in embryonic stem cells. Stem Cell Epigenetics, 1-23, A book Chapter, 2020.
119. Legartova S., J Suchankova, E Bartova. PARP dependent recruitment of RNA methylated at 8-adenosine is linked to base excision repair mechanism. Preprint Research Square, 2021.
120. Legartová, P Fagherazzi, L Stixová, A Kovařík, I Raška, E Bártová. The SC-35 Splicing Factor Interacts with RNA Pol II and A-Type Lamin Depletion Weakens This Interaction. Cells 10 (2), 297, 2021.
121. Komůrková, AS Kovaříková, E Bártová. G-Quadruplex Structures Colocalize with Transcription Factories and Nuclear Speckles Surrounded by Acetylated and Dimethylated Histones H3. International Journal of Molecular Sciences 22 (4), 2021