2026
Prof. Eva Bártová, director of the Institute of Biophysics, has been elected as a member of the Scientific Council of the Faculty of Science at Masaryk University in Brno.
/Aktuality_z_odd%C4%9Blen%C3%AD/V%C4%9Bdeck%C3%A1_rada_AG.jpg)
We present the methodological capabilities of our department, which cover a wide range of modern approaches as well as experimental and theoretical techniques. Our workplace is equipped with the expertise and infrastructure that enable the implementation of interdisciplinary research, from basic analytical methods to advanced specialized procedures. Thanks to the combination of an experienced team and state-of-the-art instrumentation, we are able to provide comprehensive solutions to research challenges and support innovative projects.
/Aktuality_z_odd%C4%9Blen%C3%AD/My_lab.png)
2025
Congratulations to Dr. Lenka Stixová on obtaining the INTER-EXCELLENCE Czech-American cooperation project. The project focuses on studying the effects of steroid hormones on RNA modifications in the irradiated genome and will be carried out in collaboration with the Laboratory of Receptor Biology and Gene Expression at the National Cancer Institute, National Institute of Health, USA.
/Skupina_Struktury_a_funkce_bun%C4%9B%C4%8Dn%C3%A9ho_j%C3%A1dra/PR_-_Lenka_grant.jpg)
January 2024
Our colleague Dr. Hana Polasek-Sedlackova receives a prestigious EMBO Installation Grant
Up to two-thirds of all cancers arise due to errors that occur during DNA replication. Dr. Hana Polasek-Sedlackova and her team have dedicated their research efforts to studying this phenomenon. Recently, they were awarded the prestigious EMBO Installation grant, which will enable them to explore the molecular mechanisms that guarantee accurate DNA replication.
EMBO grant recipients will receive annual financial support of €50,000 and a generous benefits package for the entire research group, including networking, mentoring, and training activities offered by EMBO.
Congratulations to Dr. Polasek-Sedlackova and her team!
July 2023
Cell differentiation and aging lead to up-regulation of FTO, while the ALKBH5 protein level was stable during aging but up-regulated during in vitro-induced cardiomyogenesis
Jana Krejčí, Orazio Angelo Arcidiacono, Radim Čegan, Katarzyna Radaszkiewicz, Jiří Pacherník, Jan Pirk, Martin Pešl, Petr Filaand Eva Bártová
V srpnu 2023 vyjde v časopise Physiological Research práce Krejčí et al. V této práci jsme studovali funkci dvou proteinů demetylujících RNA. Zjistili jsme, že v porovnání s proteinem ALKBH5, prochází hladina proteinu FTO daleko významnějšími změnami během buněčné diferenciace a stárnutí. Dospěli jsme k závěru, že během stárnutí a diferenciace buněk do cardiomyocytů je methylace RNA v pozici m6A pravděpodobně regulována preferenční demetylujícím proteinem FTO.
