WORKSHOP INVITATION: ScanR workshop: Pushing the bounderies of high-content imaging
Our laboratory is happy to host the sencond ScanR workshop: Pushing the bounderies of high-content imaging. The workshop will offer a great lineup of speakers with the aim to build a community of leading scientists and experts in high-content imaging to discuss and share knowledge about the latest advancements. Four hands-on sessions on sample preparation, acquisition, data analysis, and presentation. Scientists and experts from various research disciplines, at all career stages, and with any level of experience in high-content imaging are welcome to join us.
🙏 We sincerely thank Evident Life Science, SVEN BioLabs s.r.o., and EMBO for their help and support in organizing this workshop.
👉 See more information here: https://scanrbrno.ibp.cz/
April 2024
NEW LAB PAPER: Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity
DNA replication is the essential process of life. The entire process starts with replication licensing, during which MCM protein complexes 'molecular motors of DNA replication' are loaded on DNA. In a recent review, our colleagues Anoop Kumar Yadav and Hana Polasek-Sedlackova summarized the latest findings on the biology of MCM complexes and how this can be exploited in cancer therapies. The full text of the article can be found here: https://rdcu.be/dyhfJ or under the QR code. The work was supported by grants from the Czech Science Foundation Junior Star (grant no. 22-20303M), the European Research Executive Agency under Horizon 2022 Widera Talent program (ERA grant agreement no. 101090292), and Jihomoravske centrum pro mezinarodni mobilitu (JCMM) project scholarship for foreign students. Enjoy the reading!
February 2024
TALK INVITATION: The Bright and the dark sides of DNA replication stress in human cell physiology and cancer by Assoc. Prof. Kumar Somyajit
On March 14, our laboratory will host Assoc. Prof. Kumar Somyajit at the Institute of Biophysics in Brno. Come to his talk and learn more about DNA replication stress in physiology and cancer.
February 2024
NEW FUNDING: Dr. Hana Polasek-Sedlackova receives a prestigious EMBO Installation Grant
EMBO Installation Grants support group leaders in establishing laboratories in participating countries to strengthen life sciences there. Recipients of the EMBO IG will receive annual grant support in the amount of 50,000 euros and a generous package of benefits for the principal investigator and entire research group, including networking, mentoring, and training offered by the EMBO. Dr. Hana Polasek-Sedlackova and her research group are going to study fundamental molecular mechanisms that couples DNA replication with cell cycle control essential to prevent genome instability and the development of severe diseases, such as cancer. Congratulations!
Foto: Jana Mensatorová
Read more about the funding and project here or here.
January 2024
OPEN POSITION: Postdoc position in DNA replication & genome stability
A postdoc position is available in our lab🔬. If you are interested in DNA replication & genome stability, please get in touch. More information can be found here.
December 2023
NEW FUNDING: MSc. Simran Negi receives a prestigious JCMM scholarship
JCMM scholarship supports talented foreign students from non-EU countries who study technical and natural sciences at four selected universities in Brno. Simran Negi is going to study the molecular interplay between DNA replication and cell cycle control. Many Congratulations! Read short interview with Simran here.
November 2023
OUTREACH ACTIVITY: Researchers' Night at IBP 2023
Last Friday, our institute hosted the Researchers' Night 2023. Our lab prepared a detective story for visitors to show that our research work is often inspired by the detective story, but our crime scene is usually the cell, and the suspects are proteins. Thanks for coming, and see you next year! #ERAfellowship #PublicEducation
October 2023
WORKSHOP INVITATION: IBP career day: Per Aspera Ad Astra 2023
Our lab is the main organizer of IBP career day: Per Aspera Ad Astra 2023. The career day is focused on future career possibilities in the academic and industrial spheres. During the event, four outstanding scientists will share stories of their scientific journeys and will lead popular round table discussions on various topics. We look forward to meeting you! More information here. Registration link here.
September 2023
MEETING INVITATION: ScanR user meeting
The first ScanR user meeting, at which researchers from Czech research institutions will gather to share their knowledge and experience with the system. Two talks will be from the small IBP ScanR community #DNAreplication & #PlantTissue.
👉 See more information here: https://lnkd.in/em5Hsgrv
👉 Free registration here: https://lnkd.in/ej4hsXsE
August 2023
THESIS DEFENCE: New protein factors in the regulation of human DNA replication origins
Many congratulations to Anna Hrdličková, who successfully defended her bachelor thesis on the topic of New protein factors in the regulation of human DNA replication origins.
June 2023
TALK INVITATION: Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress by Dr. Jan Benada
On May 25-26, we will host Dr. Jan Benada at the Institute of Biophysics in Brno. Come to his talk and learn more about self-inflicted DNA breaks.
May 2023
NEW PAPER: 110 μm thin endo-microscope for deep-brain in vivo observations of neuronal connectivity, activity and blood flow dynamics
Dr. Jana Krejčí contributed to develop a new endo-microscopy technique for in-vivo brain imaging. Congratulations! Read about the story in Nature Communications.
April 2023
NEW FUNDING: Dr. Hana Polasek-Sedlackova receives a prestigious ERA individual fellowship from the European Research Executive Agency
ERA individual fellowship action builds on the MSCA postdoctoral fellowships 2023 action and supports career development and training of researchers in all scientific disciplines in Widening Countries. ERA fellowship covers living allowances, mobility allowances, family allowances, research and training costs, and administration and indirect costs. In terms of amount, the ERA fellowships belong to the most prestigious individual fellowships in Europe. Dr. Hana Polasek-Sedlackova is going to study replication origins during normal development and tumorigenesis. Congratulations!
January 2023
NEW FUNDING: MSc. Anoop Kumar Yadav receives a prestigious JCMM scholarship
JCMM scholarship supports talented foreign students from non-EU countries who study technical and natural sciences at four selected universities in Brno. Anoop Kumar Yadav is going to study the regulation and maintenance of human replication origins during cancer development. Congratulations!
December 2022
TALK INVITATION: Cullin-dependent ubiquitin ligases in cancer progression by Dr. Lukáš Čermák 
November 2022
NEW PAPER: Early recruitment of PARP-dependent m8A RNA methylation at DNA lesions is subsequently accompanied by active DNA demethylation
A new paper from the laboratory of Dr. Eva Bartova described the role of RNA modifications in base excision repair. Our laboratory contributed to this beautiful story through high-content imaging. Many congratulations to all authors! Read about the story here.
November 2022
NEW LAB PAPER: Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes
For several decades, the MCM2-7, the core of the replicative helicase, had never been visualized at DNA replication sites inside a cell, also known as the MCM paradox. Scientists from the Institute of Biophysics of the Czech Academy of Sciences and the University of Copenhagen revisit the mysterious MCM paradox, and their study published last week in Nature Communications solves this puzzling conundrum by CRISPR-Cas9 genome editing. These findings enable visualization of replication dynamics in living cells and open new avenues for understanding the molecular basis of serious human health diseases, such as cancer. Read more about the story here.
Read about the story on ScienceNews.
October 2022
NEW FUNDING: Dr. Hana Polasek-Sedlackova receives a prestigious Junior Star starting grant from the Czech Science Foundation
The JUNIOR STAR starting grants are intended for excellent early career scientists with strong research profiles and ambitious research proposals. Thanks to a five-year project with the possibility of drawing up to 25 million CZK, they get the opportunity to establish their own research group bringing new scientific topics to Czech science. Dr. Hana Polasek-Sedlackova and her new group is going to study how DNA replication is regulated in human cells to achieve a faithful copy of DNA, which is essential to prevent the emergence of mutations and genome instability associated with severe diseases of human health including cancer. The proposed research can lead to the design of new strategies in cancer treatment. Congratulations!
Read more about the project on the Czech Science Foundation webpage here.
February 2022