The adenylyl cyclase signaling pathway is considered to be a key regulator of immune system function - a new paper from the Department of Biophysics of the Immune System

17. 11. 2023

New research focusing on the immune system suggests that the adenylyl cyclase (AC) signaling pathway may play a key role in regulating immune system function. The study focused on the effects of cyclic adenosine monophosphate (cAMP) on the differentiation and function of T helper (Th) cells, specifically on the development of Th1, Th2 and Th17 subsets.

New research focused on the immune system suggests that the adenylyl cyclase (AC) signaling pathway may play a key role in regulating immune system function. The study focused on the effects of cyclic adenosine monophosphate (cAMP) on the differentiation and function of T helper (Th) cells, specifically on the development of Th1, Th2 and Th17 subsets.



The researchers used forskolin (FSK), a known AC activator, and found that FSK increased specific markers for Th1 and promoted Th2 differentiation, albeit with negative effects on cell metabolism. In contrast, the Th17 immunophenotype was strongly suppressed with a highly specific increase in CXCL13. The study also confirmed a causal link between FSK-activated cAMP production and the observed effects on Th2 differentiation by the AC inhibitor. Overall, it suggests that cAMP elevation by FSK can affect Th1, Th2 and Th17 differentiation, which may contribute to the identification of novel therapeutic targets for the treatment of Th cell-associated pathologies.



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