G-quadruplexes in the evolution of hepatitis B virus

4. 7. 2023

The prestigious journal Nucleic Acids Research is again publishing the results of IBP scientists.

Hepatitis B virus (HBV) is one of the most dangerous human pathogenic viruses found in all corners of the world. Recent sequencing of ancient HBV viruses has revealed that these viruses have been with mankind for several millennia. What has been discovered by examining the sequences that make up the G-quadruplexes (PQS) in modern and ancient HBV genomes that are considered potential therapeutic targets in virology?

This was the focus of an article in the prestigious NAR journal NAR Nucleic Acids Research. The authors are members of the IBP from the team of Václav Brázda in collaboration with Jean-Louis Mergny. Congratulations!!!