Management of Biofyzikální ústav AV ČR, v. v. i.,
Královopolská 2590/135, 612 00 Brno

announces a selection procedure

Job title: PhD student - Bioinformatics
Scientific department: Department of Biophysics of Immune System

Project: NW25-08-00135 - Biodegradable polyester nanomaterials as a biotechnology platform for targeted therapy of rheumatoid arthritis, Funding provider: Czech Health Research Council

Size of workload: 0.65 FTE
Length of employment: 1. 10. 2026 – 31. 12. 2027

Minimum educational attainment: Master's degree
Qualification level: R1
Professional requirements:

• Knowledge of the principles of molecular and cellular immunology, particularly the biology of T and B lymphocytes, antigen-specific immune responses, TCR/BCR signaling, and the mechanisms of autoimmune and chronic inflammatory diseases.
• Experience with basic methods of experimental immunology and molecular biology, particularly processing primary biological samples, preparing samples or libraries for sequencing, and cell culture.
• Knowledge of high-dimensional biological data analysis and experience with statistical processing in R and/or Python.
• Knowledge of processing and bioinformatic analysis of transcriptomic data generated by bulk RNA-seq and single-cell RNA-seq, including quality control, normalization, data integration, and differential expression analysis.
• Knowledge of the principles of TCR and/or BCR repertoire analysis, including assessment of clonality, diversity, clonal expansion, and convergence of receptor sequences.
• Experience using publicly available transcriptomic and sequencing databases and systematically processing and integrating data from multiple independent datasets.
• Knowledge of functional and pathway analysis of transcriptomic data, including gene-set enrichment methods and the use of biological databases such as Gene Ontology, KEGG, and Reactome.
• Knowledge of the principles of structural bioinformatics and molecular protein modeling, particularly prediction of 3D receptor structures, analysis of protein–protein/protein–peptide interactions, and prediction of antigenic epitopes.
• Ability to link bioinformatic analysis with experimental validation of results, including designing experiments for functional validation of candidate receptors, antigens, or molecular markers.

Language requirements: English, minimum level B2

Employee benefits:

• 25 days annual leave + 3 sick days;
• flexible working hours;
• possibility of partial remote work;
• vocational and language courses;
• up to CZK 10,000 per year for recreation, sports activities or culture;
• company catering at a reduced price;
• vitamin supplements, free drinking water/fluids;
• sports and cultural teambuilding events.

Website: https://www.ibp.cz/cs/

Expected start date: 1. 10. 2026

Deadline for application: 17. 9. 2026

Applications for the selection procedure, including CV, cover letter and references (remove the redundant ones) should be sent electronically to kubalal@ibp.cz and ulrich@ibp.cz or by post to Královopolská 2590/135, 612 00 Brno, Czech Republic, with the visible indication ‘Selection Procedure + Specific Job Title’ on the envelope.