Mlýnský Vojtěch, Mgr., Ph.D.

Research Interests

• Molecular dynamics of RNA and RNA:protein complexes
• Interactions of RNA with small molecules
• Enhanced Sampling Methods and their application to RNA dynamics
• QM and QM/MM calculations of RNA catalytic reactions

Education

• 2005 – 2009 - M.Sc. Physical Chemistry, Palacký University, Olomouc
• 2009 – 2014 - Ph.D. Physical chemistry, Palacký University, Olomouc

International Experience

• 2012 - Stay at University of Bristol (group of Prof. Adrian J. Mulholland)
• 2013 - Stay at University of Michigan (group of Prof. Nils G. Walter)
• 2015 – 2018 - Postdoc at SISSA, Trieste, Italy (group of Prof. Giovanni Bussi)

Cooperation

• Prof. Giovanni Bussi, SISSA, Trieste, Italy – Enhanced Sampling Methods 

Recent Publications

Mlynsky V, Bussi G: Exploring RNA structure and dynamics through enhanced sampling simulations, CURR. OPIN. STRUCT. BIOL., in press (2018)

Mlynsky V, Bussi G: Molecular Dynamics Simulations Reveal an Interplay between SHAPE Reagent Binding and RNA Flexibility, J. PHYS. CHEM. LETT., 9(2), 313-318 (2018)

Mlynsky V, Kuhrova P, Jurecka P, Sponer J, Otyepka M, Banas P: Mapping the Chemical Space of the RNA Cleavage and its Implications for Ribozyme Catalysis, J. PHYS. CHEM. B, 121(48), 10828-10840 (2017)

Mlynsky V, Bussi G: Understanding in-line probing experiments by modeling cleavage of nonreactive RNA nucleotides, RNA, 23(5), 712-720 (2017)