The Department of Biophysics of Immune System is focused on molecular mechanisms regulating complex immune responses under both physiological and disease states including inflammation, infection and tissue injury.  

Deregulation of immune response is the underlying cause precipitating the development of a wide range of pathologies such as cardiovascular diseases and diabetes, and many others. Therefore, improving understanding of the molecular mechanisms involved in the development of these pathological processes and the effects of external factors that cause deregulation of these mechanisms will lead to development of new therapeutic strategies to treat these maladies. In collaboration with medicinal chemists and pharmacological companies, we evaluate novel potential therapeutic targets and newly designed compounds to bring about improvements to therapy in the context of human disease.

Enabling us to elucidate the molecular mechanisms that regulate function, fate and the interaction of immune cells, we utilize all basic methods of biochemistry, molecular and cell biology, biophysical methodological tools, and rely heavily on state-of-the-art proteomics and genomics. We use cell cultures and also primary immune cells isolated from healthy donors. To model pathological processes in vivo, we continue to employ a wide range of mouse models, including mice colonies with target gene modification. As required, primary patient samples are obtained in cooperation with the Faculty Hospital Brno. Whether alone or in collaboration, we are trying to take advantage of data validation in vivo where possible, having incorporated mouse experimental models to our repertoire, housed in our on-site animal facility at IBP.

You can find more information about the Department at the following link https://dbis.ibp.cz/