Internal Research Support

Mission of the Programme

• Support the research activities of young, promising researchers at the Institute, thereby facilitating the start of their scientific careers while also supporting the development of existing fields and, in the future, new fields as well.
• For already established scientific teams, bridge unexpected and non-attributable interruptions in the funding of the team’s research activities from external grant sources.
• Support the implementation of preliminary experiments designed to verify an original scientific idea/hypothesis.

Supported Projects

• Gabriela Ambrožová: AhR Ligands as Regulators of Anti-Tumor Immunity in Melanoma
• Jana Perečková: From Treatment to Metastasis: Radiotherapy and Hypoxia Reprogram Neutrophils in Head and Neck Cancer
• Martina Outlá: Electrochemical Behavior of Selected Ligands Recognizing G-Quadruplexes in the Absence and Presence of Various DNA Structures

• Iva Kejnovská – Kinetically Preferred Structures of Guanine Quadruplexes

• Lukáš Fojt – New Possibilities in Electrochemical Analysis of Biomolecules Based on Boron Cluster Compounds as Tunable Redox Labels
• Olga Nováková – Biophysical Analysis of Metal-Based Drug–Protein Conjugates. Effect of Carrier Protein on the Transport of New Organometallic Antitumor Compounds.

• Lucie Horáková – Establishing Advanced Cytogenetic and Imaging Methods to Study Genome Instabilities in Common Hop (Humulus lupulus).

• Lucie Kajan Grodecká – Metagenomic Analysis of the Soil Microbiome: Evaluation and Optimization of Methodology
• Gabriela Ambrožová – Eukaryotic EVs as Transporters of Pro-inflammatory and Bacterial Cargo
• Hana Polášek Sedláčková – Regulation of Human ORC Complex During Genome Duplication

• Zdeněk Kubát – Temporally and Spatially Restricted Mobilization of Transposons in Plants
• Daniel Renčiuk – Alternative Structures of Nucleic Acids
• Eva Sýkorová – Characterization of the Properties of Telomerase Interaction Partners

• Leon Jenner – Characterising Telomerase RNA Binding Proteins in Plants
• Zuzana Kahounová – Innovative Multiparametric Approach for Circulating Tumor Cell Detection and Analysis
• Alena Svobodová Kovaříková – The Role of the RNA Modification N6,N6-Dimethyladenosine in the Repair of Human Skin Cells Damaged by UV Radiation
• Vazquez Goméz – Development of In Vitro Model(s) for Assessing the Role of the AhR/CYP1 Axis in the Production of Reactive PAH Metabolites

• Magdaléna Skalníková: Effect of NAT10 on Chromatin Structure After UV-Light Irradiation Using the Hi-C Method
• José Luis Rodriguez Lorenzo: Cytosine Oxidative Modifications as Evolutive Architects of Silene latifolia Sex Chromosomes
• Zuzana Dvořáková: Structural Changes in Nucleic Acids After Binding of Silver Ions in the Context of Antimicrobial Activity
• Radka Kalfusová: Identification and Analysis of Repetitive Sequences in the Assembled R. canina Chromosomes

• Vlastimil Tichý: The Role of Non-coding RNAs in the Initiation of the UV-induced DNA Damage Response
• Vojtěch Hudzieczek: Genome-wide Analysis of Transcription Factor Binding Sites to Identify Regulatory Networks Controlled by Sex Chromosomes
• Jana Lunerová: Epigenetic Regulation of Bivalent and Univalent Chromosomes in Dogroses
• Pavel Veverka: Elucidation of the Function of the Codanin-1 Protein in the Regulation of Histone Deposition Through Interaction with ASF1 and CDIN1

• Václav Bačovský: The Ultrastructure of the Synaptonemal Complex in Plants with Young Sex Chromosomes During Meiotic Prophase
• Jana Krejčí: Characteristics of the Epigenome and Epitranscriptome During the Differentiation of Embryonic Stem Cells and During Mouse Embryonic Development
• Jiřina Procházková: Surface Profiling of Glycosphingolipids in Breast Cancer
• Martin Stojaspal: Characterization of Factors Affecting Congenital Dyserythropoietic Anemia I – Determination of the Structure and Description of Interactions of the CDIN1 and CDAN1 Proteins
• Lenka Šindlerová: Mechanism of the Pro-inflammatory Effects of Selected Cyanobacterial Lipopolysaccharides

• Soňa Legartová: The Epigenetics of the DNA Damage Response in Cancer Cells
• Kristýna Turková: Extracellular Vesicles Produced by Bacteria of the Genus Lactobacillus and Their Immunomodulatory Effects In Vitro

• Alessio Cantara: New G-quadruplex Ligands and Their Effect on the Viability of Tumour Cell Lines; Localization and Interaction with DNA
• Ctirad Hofr: Quantitative Biophysical Characterization of Factors Affecting the Development of Anemia – Pilot Support for the New Department of Quantitative Biophysics of Assoc. Prof. Ctirad Hofr
• Pavel Jedlička: Dynamics of LTR Retrotransposons in Plant Genomes with Holocentric Chromosomes

• Stanislav Hasoň: Detection of Selected Groups of Substances in Body Fluids Using the Unique Properties of Graphene Oxides. Insight into the Nature of Electrochemical Oxidation Processes Generating Graphene Oxides of Different Morphologies
• Denisa Komůrková: Spatial Mapping of the Occurrence of DNA G-quadruplexes in the Nucleus in Relation to DNA Repair
• Lenka Stixová: Epigenetics of the Nucleolus After DNA Damage
• Ondřej Vašíček: Natural Pseurotins as Potential Cytostatics in Human Lymphomas
• Jan Víteček: The Role of the CD44 Receptor and the Hippo Signaling Pathway in Endothelial Inflammation

• Marie Brázdová: The Effect of G-quadruplex Structure on Its Recognition by p53 Proteins
• Milan Číž: Hypoxia-induced Epigenetic Changes Modulate the Functional Plasticity of Neutrophils
• Andrea Horáková: Interphase Organization of X Chromosomes in Pluripotent Cells
• Emil Paleček: Chemical Modification and Electrochemical Analysis of Glycans and Glycoproteins as New Tools in the Diagnosis of Socially Significant Diseases
• Michal Štros: HMGB Proteins: New Regulators in the Biology of Human Telomeres