News

BFÚ spolupořádá konferenci

XXXVI. Moderní elektrochemické metody

New publications

Recruitment of Oct4 Protein to UV-Damaged Chromatin in Embryonic Stem Cells

Bartova, E., Sustackova, G., Stixova, L., Kozubek, S., Legartova, S., Foltankova, V.

Energetics, conformation, and recognition of DNA duplexes containing a major adduct of an anticancer azolato-bridged dinuclear Pt-II complex

Mlcouskova, J., Malina, J., Novohradsky, V., Kasparkova, J., Komeda, S., Brabec, V.

A-Minor Tertiary Interactions in RNA Kink-Turns. Molecular Dynamics and Quantum Chemical Analysis

Reblova, K., Sponer, JE., Spackova, N., Besseova, I., Sponer, J.

Recognition of DNA bulges by dinuclear iron(II) metallosupramolecular helicates

Malina, J., Hannon, MJ., Brabec, V.

Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer

Kasparkova, J., Thibault, T., Kostrhunova, H., Stepankova, J., Vojtiskova, M., Muchova, T., Midoux, P., Malinge, JM., Brabec, V.
Further publications

Selected results

Strukturní vlastnosti DNA - nositelky genetické informace

Jedním z renomovaných světových pracovišť, systematicky a dlouhodobě se zabývajících studiem strukturních vlastností nukleových kyselin je laboratoř Prof. RNDr. Michaely Vorlíčkové, DrSc. 

Fagocyty ve zdraví a nemoci

Fagocyty (neutrofily, monocyty, makrofágy) jsou nezastupitelnými buňkami první obranné linie, chránicími tělo před invadujícími mikrobiálními patogeny. 

Osmium tetroxide, 2,2'-bipyridine (Os,bipy): Electroactive marker for probing accessibility of tryptophan residues in proteins.

Os,bipy forms at physiological conditions electroactive covalent adducts with tryptophan residues. 

Electroactive labeling of DNA and PNA by osmium tetroxide complexes

The labeling reaction can be performed in any biochemical or biological laboratory without any special requirements for equipment or expertise.

Mechanisms of DNA binding by tumor suppressor protein p53

Recognition of specific binding sites in DNA by the tumor suppressor protein p53 is given not only by nucleotide sequence of the binding site, but also by local and global DNA structure.

Further results