A special issue of Monatshefte für Chemie devoted to conferences co-organized by the Instittute of Biophysics in 2014
XXXV. Moderní elektrochemické metody
Novel strategies of labeled nucleic acids construction and their application in electrochemical DNA sensing
Collaboration with the group of M. Hocek at the IOCB ASCR in Prague resulted in development of novel facile techniques of enzymatic construction of modified nucleic acids.
Electrochemical approaches have been applied to detect specific nucleobase lesions and to design fast techniques for the monitoring of DNA-processing enzymes activity.
Recognition of specific binding sites in DNA by the tumor suppressor protein p53 is given not only by nucleotide sequence of the binding site, but also by local and global DNA structure.