Publications Overview of the Department of Cytokinetics

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2012

• Chaki, M., Airik, R., Ghosh, AK., Giles, RH., Chen, R., Slaats, GG., Wang, H., Hurd, TW., Zhou, WB., Cluckey, A., Gee, HY., Ramaswami, G., Hong, CJ., Hamilton, BA., Cervenka, I., Ganji, RS., Bryja, V., Arts, HH., van Reeuwijk, J., Oud, MM., Letteboer, SJF., Roepman, R., Husson, H., Ibraghimov-Beskrovnaya, O., Yasunaga, T., Walz, G., Eley, L., Sayer, JA., Schermer, B., Liebau, MC., Benzing, T., Le Corre, S., Drummond, I., Janssen, S., Allen, SJ., Natarajan, S., O'Toole, JF., Attanasio, M., Saunier, S., Antignac, C., Koenekoop, RK., Ren, HN., Lopez, I., Nayir, A., Stoetzel, C., Dollfus, H., Massoudi, R., Gleeson, JG., Andreoli, SP., Doherty, DG., Lindstrad, A., Golzio, C., Katsanis, N., Pape, L., Abboud, EB., Al-Rajhi, AA., Lewis, RA., Omran, H., Lee, EYHP., Wang, SH., Sekiguchi, JM., Saunders, R., Johnson, CA., Garner, E., Vanselow, K., Andersen, JS., Shlomai, J., Nurnberg, G., Nurnberg, P., Levy, S., Smogorzewska, A., Otto, EA., Hildebrandt, F. (2012), Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling, CELL 150, 533-548 [AIS=20.554, IF=32.403 H]
• Wang, YL., Zhou, XY., Oberoi, K., Phelps, R., Couwenhoven, R., Sun, M., Rezza, A., Holmes, G., Percival, CJ., Friedenthal, J., Krejci, P., Richtsmeier, JT., Huso, DL., Rendl, M., Jabs, EW. (2012), p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice, JOURNAL OF CLINICAL INVESTIGATION 122, 2153-2164 [AIS=6.944, IF=13.069 H]
• Merrill, AE., Sarukhanov, A., Krejci, P., Idoni, B., Camacho, N., Estrada, KD., Lyons, KM., Deixler, H., Robinson, H., Chitayat, D., Curry, CJ., Lachman, RS., Wilcox, WR., Krakow, D. (2012), Bent Bone Dysplasia-FGFR2 type, a Distinct Skeletal Disorder, Has Deficient Canonical FGF Signaling, AMERICAN JOURNAL OF HUMAN GENETICS 90, 550-557 [AIS=5.867, IF=10.083 H]
• Lee, H., Graham, JM., Rimoin, DL., Lachman, RS., Krejci, P., Tompson, SW., Nelson, SF., Krakow, D., Cohn, DH. (2012), Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis, AMERICAN JOURNAL OF HUMAN GENETICS 90, 746-751 [AIS=5.867, IF=10.083 H]
• Krejci, P., Aklian, A., Kaucka, M., Sevcikova, E., Prochazkova, J., Masek, JK., Mikolka, P., Pospisilova, T., Spoustova, T., Weis, M., Paznekas, WA., Wolf, JH., Gutkind, JS., Wilcox, WR., Kozubik, A., Jabs, EW., Bryja, V., Salazar, L., Vesela, I., Balek, L. (2012), Receptor Tyrosine Kinases Activate Canonical WNT/beta-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct beta-Catenin Phosphorylation, PLOS ONE 7 [AIS=1.797, IF=4.092]
• Knopfova, L., Benes, P., Pekarcikova, L., Hermanova, M., Masarik, M., Pernicova, Z., Soucek, K., Smarda, J. (2012), c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis, MOLECULAR CANCER 11 [AIS=1.578, IF=3.993 H]
• Hofmanova, J., Ciganek, M., Slavik, J., Kozubik, A., Stixova, L., Vaculova, A., Dusek, L., Machala, M. (2012), Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids, JOURNAL OF NUTRITIONAL BIOCHEMISTRY 23, 539-548 [AIS=1.035, IF=3.891 H]
• Valovicova, Z., Mesarosova, M., Trilecova, L., Hruba, E., Marvanova, S., Krcmar, P., Milcova, A., Schmuczerova, J., Vondracek, J., Machala, M., Topinka, J., Gabelova, A. (2012), Genotoxicity of 7H-dibenzo[c,g]carbazole and its methyl derivatives in human keratinocytes, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 743, 91-98 [AIS=0.752, IF=3.035 H]
• Hammerova, J., Uldrijan, S., Taborska, E., Vaculova, AH., Slaninova, I. (2012), Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine, BIOLOGICAL CHEMISTRY 393, 647-658 [AIS=1.026, IF=2.965 H]
• Foldynova-Trantirkova, S., Wilcox, WR., Krejci, P. (2012), Sixteen Years and Counting: The Current Understanding of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling in Skeletal Dysplasias, HUMAN MUTATION 33, 29-41 [AIS=2.344, IF=5.686 VH]
• Starsichova, A., Hruba, E., Slabakova, E., Pernicova, Z., Prochazkova, J., Pencikova, K., Seda, V., Kabatkova, M., Vondracek, J., Kozubik, A., Machala, M., Soucek, K. (2012), TGF-beta 1 signaling plays a dominant role in the crosstalk between TGF-beta 1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells, CELLULAR SIGNALLING 24, 1665-1676 [AIS=1.478, IF=4.058 VH]
• Vanhara, P., Hampl, A., Kozubik, A., Soucek, K. (2012), Growth/differentiation factor-15: prostate cancer suppressor or promoter?, PROSTATE CANCER AND PROSTATIC DISEASES 15, 320-328 [AIS=0.632, IF=2.421 VH]
• Koci, L., Chlebova, K., Hyzdalova, M., Hofmanova, J., Jira, M., Kysela, P., Kozubik, A., Kala, Z., Krejci, P. (2012), Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo, ONCOLOGY LETTERS 3, 913-916 [AIS=0.023, IF=0.106 VH]

2011

• Bernatik, O., Ganji, RS., Dijksterhuis, JP., Konik, P., Cervenka, I., Polonio, T., Krejci, P., Schulte, G., Bryja, V. (2011), Sequential Activation and Inactivation of Dishevelled in the Wnt/beta-Catenin Pathway by Casein Kinases, JOURNAL OF BIOLOGICAL CHEMISTRY 286, 10396-10410 [AIS=2.029, IF=4.773 H]
• Prochazkova, J., Kabatkova, M., Bryja, V., Umannova, L., Bernatik, O., Kozubik, A., Machala, M., Vondracek, J. (2011), The Interplay of the Aryl Hydrocarbon Receptor and beta-Catenin Alters Both AhR-Dependent Transcription and Wnt/beta-Catenin Signaling in Liver Progenitors, TOXICOLOGICAL SCIENCES 122, 349-360 [AIS=1.353, IF=4.652 H]
• Hruba, E., Vondracek, J., Libalova, H., Topinka, J., Bryja, V., Soucek, K., Machala, M. (2011), Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands, TOXICOLOGY LETTERS 206, 178-188 [AIS=0.886, IF=3.581 H]
• Gabelova, A., Valovicova, Z., Mesarosova, M., Trilecova, L., Hruba, E., Marvanova, S., Krcmar, P., Milcova, A., Schmuczerova, J., Vondracek, J., Machala, M., Topinka, J. (2011), Genotoxicity of 7H-dibenzo[c,g]carbazole and Its Tissue-Specific Derivatives in Human Hepatoma HepG2 Cells Is Related to CYP1A1/1A2 Expression, ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 52, 636-645 [AIS=0.743, IF=3.493 H]
• Pernicova, Z., Slabakova, E., Kharaishvili, G., Bouchal, J., Kral, M., Kunicka, Z., Machala, M., Kozubik, A., Soucek, K. (2011), Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2, NEOPLASIA 13, 526-536 [AIS=1.689, IF=5.946 VH]
• Blanarova, OV., Jelinkova, I., Szoor, A., Skender, B., Soucek, K., Horvath, V., Vaculova, A., Andera, L., Sova, P., Szollosi, J., Hofmanova, J., Vereb, G., Kozubik, A. (2011), Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway, CARCINOGENESIS 32, 42-51 [AIS=1.543, IF=4.795 VH]
• Vondracek, J., Umannova, L., Machala, M. (2011), Interactions of the Aryl Hydrocarbon Receptor with Inflammatory Mediators: Beyond CYP1A Regulation, CURRENT DRUG METABOLISM 12, 89-103 [AIS=1.197, IF=3.896 VH]
• Umannova, L., Machala, M., Topinka, J., Schmuczerova, J., Krcmar, P., Neca, J., Sujanova, K., Kozubik, A., Vondracek, J. (2011), Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells, TOXICOLOGY LETTERS 206, 121-129 [AIS=0.886, IF=3.581 VH]
• Koci, L., Hyzd'alova, M., Vaculova, A., Hofmanova, J., Kozubik, A. (2011), Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial colon cells, CYTOKINE 55, 34-39 [AIS=0.933, IF=3.537 VH]
• Prochazkova, J., Kozubik, A., Machala, M., Vondracek, J. (2011), Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells, TOXICOLOGY 279, 146-154 [AIS=0.796, IF=3.241 VH]
• Kaucka, M., Krejci, P., Plevova, K., Pavlova, S., Prochazkova, J., Janovska, P., Valnohova, J., Kozubik, A., Pospisilova, S., Bryja, V. (2011), Post-translational modifications regulate signalling by Ror1, ACTA PHYSIOLOGICA 203, 351-362 [AIS=0.982, IF=3.138 VH]
• Tanneberger, K., Pfister, AS., Kriz, V., Bryja, V., Schambony, A., Behrens, J. (2011), Structural and Functional Characterization of the Wnt Inhibitor APC Membrane Recruitment 1 (Amer1), JOURNAL OF BIOLOGICAL CHEMISTRY 286, 19204-19214 [AIS=5.299, IF=10.124 H]
• Tanneberger, K., Pfister, AS., Brauburger, K., Schneikert, J., Hadjihannas, MV., Kriz, V., Schulte, G., Bryja, V., Behrens, J. (2011), Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P-2 to LRP6 phosphorylation, EMBO JOURNAL 30, 1433-1443 [AIS=5.552, IF=8.993 H]
• Scuto, A., Krejci, P., Popplewell, L., Wu, J., Wang, Y., Kujawski, M., Kowolik, C., Xin, H., Chen, L., Wang, Y., Kretzner, L., Yu, H., Wilcox, WR., Yen, Y., Forman, S., Jove, R. (2011), The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival, LEUKEMIA 25, 538-550 [AIS=2.82, IF=8.966 H]
• Cervenka, I., Wolf, J., Masek, J., Krejci, P., Wilcox, WR., Kozubik, A., Schulte, G., Gutkind, JS., Bryja, V. (2011), Mitogen-Activated Protein Kinases Promote WNT/beta-Catenin Signaling via Phosphorylation of LRP6, MOLECULAR AND CELLULAR BIOLOGY 31, 179-189 [AIS=3.435, IF=6.057 H]
• Hamers, T., Kamstra, JH., Cenijn, PH., Pencikova, K., Palkova, L., Simeckova, P., Vondracek, J., Andersson, PL., Stenberg, M., Machala, M. (2011), In Vitro Toxicity Profiling of Ultrapure Non-Dioxin-like Polychlorinated Biphenyl Congeners and Their Relative Toxic Contribution to PCB Mixtures in Humans, TOXICOLOGICAL SCIENCES 121, 88-100 [AIS=1.323, IF=5.093 H]
• Trilecova, L., Krckova, S., Marvanova, S., Pencikova, K., Krcmar, P., Neca, J., Hulinkova, P., Palkova, L., Ciganek, M., Milcova, A., Topinka, J., Vondracek, J., Machala, M. (2011), Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells, CHEMICAL RESEARCH IN TOXICOLOGY 24, 866-876 [AIS=0.965, IF=4.14 H]
• Kilander, MBC., Dijksterhuis, JP., Ganji, RS., Bryja, V., Schulte, G. (2011), WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins, CELLULAR SIGNALLING 23, 550-554 [AIS=1.666, IF=4.094 H]
• Benes, P., Knopfova, L., Trcka, F., Nemajerova, A., Pinheiro, D., Soucek, K., Fojta, M., Smarda, J. (2011), Inhibition of topoisomerase II alpha: Novel function of wedelolactone, CANCER LETTERS 303, 29-38 [AIS=1.007, IF=3.741 H]
• Slabakova, E., Pernicova, Z., Slavickova, E., Starsichova, A., Kozubik, A., Soucek, K. (2011), TGF-beta 1-Induced EMT of Non-Transformed Prostate Hyperplasia Cells Is Characterized by Early Induction of SNAI2/Slug, PROSTATE 71, 1332-1343 [AIS=0.999, IF=3.377 VH]
• Andrysik, Z., Vondracek, J., Marvanova, S., Ciganek, M., Neca, J., Pencikova, K., Mahadevan, B., Topinka, J., Baird, WM., Kozubik, A., Machala, M. (2011), Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 714, 53-62 [AIS=1.366, IF=3.204 H]
• Mikes, J., Hyzdalova, M., Koci, L., Jendzelovsky, R., Koval, J., Vaculova, A., Hofmanova, J., Kozubik, A., Fedorocko, P. (2011), Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin, PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 10, 626-632 [AIS=0.815, IF=2.708 H]

2010

• Andrysik, Z., Bernstein, WZ., Deng, L., Myer, DL., Li, YQ., Tischfield, JA., Stambrook, PJ., Bahassi, E. (2010), The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus, NUCLEIC ACIDS RESEARCH 38, 2931-2943 [AIS=3, IF=7.48 H]
• Witte, F., Bernatik, O., Kirchner, K., Masek, J., Mahl, A., Krejci, P., Mundlos, S., Schambony, A., Bryja, V., Stricker, S. (2010), Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2, FASEB JOURNAL 24, 2417-2426 [AIS=2.521, IF=6.401 H]
• Lindqvist, M., Horn, Z., Bryja, V., Schulte, G., Papachristou, P., Ajima, R., Dyberg, C., Arenas, E., Yamaguchi, TP., Lagercrantz, H., Ringstedt, T. (2010), Vang-like protein 2 and Rac1 interact to regulate adherens junctions, JOURNAL OF CELL SCIENCE 123, 472-483 [AIS=3.251, IF=6.144 H]
• Krejci, P., Murakami, S., Prochazkova, J., Trantirek, L., Chlebova, K., Ouyang, ZF., Aklian, A., Smutny, J., Bryja, V., Kozubik, A., Wilcox, WR. (2010), NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells, JOURNAL OF BIOLOGICAL CHEMISTRY 285, 20644-20653 [AIS=2.223, IF=5.328 H]
• Schulte, G., Schambony, A., Bryja, V. (2010), beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?, BRITISH JOURNAL OF PHARMACOLOGY 159, 1051-1058 [AIS=1.316, IF=5.204 H]
• Andersson, E., Bryjova, L., Biris, K., Yamaguchi, TP., Arenas, E., Bryja, V. (2010), Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development, DEVELOPMENTAL DYNAMICS 239, 237-245 [AIS=1.4, IF=2.833 H]
• Soucek, K., Slabakova, E., Ovesna, P., Malenovska, A., Kozubik, A., Hampl, A. (2010), Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma, HUMAN REPRODUCTION 25, 2962-2971 [AIS=0.978, IF=3.859 VH]
• Sousa, KM., Villaescusa, JC., Cajanek, L., Ondr, JK., Castelo-Branco, G., Hofstra, W., Bryja, V., Palmberg, C., Bergman, T., Wainwright, B., Lang, RA., Arenas, E. (2010), Wnt2 Regulates Progenitor Proliferation in the Developing Ventral Midbrain, JOURNAL OF BIOLOGICAL CHEMISTRY 285, 7246-7253 [AIS=2.222, IF=5.328 H]
• Foldynova-Trantirkova, S., Sekyrova, P., Tmejova, K., Brumovska, E., Bernatik, O., Blankenfeldt, W., Krejci, P., Kozubik, A., Dolezal, T., Trantirek, L., Bryja, V. (2010), Breast cancer-specific mutations in CK1 epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration, BREAST CANCER RESEARCH 12, R30 [AIS=1.788, IF=5.326 H]
• Starsichova, A., Lincova, E., Pernicova, Z., Kozubik, A., Soucek, K. (2010), TGF-beta 1 suppresses IL-6-induced STAT3 activation through regulation of Jak2 expression in prostate epithelial cells, CELLULAR SIGNALLING 22, 1734-1744 [AIS=1.666, IF=4.094 VH]
• Krejci, P., Prochazkova, J., Smutny, J., Chlebova, K., Lin, P., Aklian, A., Bryja, V., Kozubik, A., Wilcox, WR. (2010), FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence, BONE 47, 102-110 [AIS=1.414, IF=4.089 H]
• Hruba, E., Trilecova, L., Marvanova, S., Krcmar, P., Vykopalova, L., Milcova, A., Libalova, H., Topinka, J., Starsichova, A., Soucek, K., Vondracek, J., Machala, M. (2010), Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells, TOXICOLOGY LETTERS 197, 227-235 [AIS=0.831, IF=3.479]
• Uhlirova, R., Horakova, AH., Galiova, G., Legartova, S., Matula, P., Fojtova, M., Varecha, M., Amrichova, J., Vondracek, J., Kozubek, S., Bartova, E. (2010), SUV39h-and A-Type Lamin-Dependent Telomere Nuclear Rearrangement, JOURNAL OF CELLULAR BIOCHEMISTRY 109, 915-926 [AIS=1.151, IF=2.935 V]
• Cajanek, L., Adlerz, L., Bryja, V., Arenas, E. (2010), WNT Unrelated Activities in Commercially Available Preparations of Recombinant WNT3a, JOURNAL OF CELLULAR BIOCHEMISTRY 111, 1077-1079 [AIS=1.151, IF=2.935 H]
• Kulikova, L., Mikes, J., Hyzdalova, M., Palumbo, G., Fedorocko, P. (2010), NF-kappa B is Not Directly Responsible for Photoresistance Induced by Fractionated Light Delivery in HT-29 Colon Adenocarcinoma Cells, PHOTOCHEMISTRY AND PHOTOBIOLOGY 86, 1285-1293 [AIS=0.707, IF=2.253 H]
• Soucek, K., Gajduskova, P., Brazdova, M., Hyzd'alova, M., Koci, L., Vydra, D., Trojanec, R., Pernicova, Z., Lentvorska, L., Hajduch, M., Hofmanova, J., Kozubik, A. (2010), Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation, CANCER GENETICS AND CYTOGENETICS 197, 107-116 [AIS=0.42, IF=1.537 VH]
• Svihalkova-Sindlerova, L., Foltinova, V., Vaculova, A., Horvath, V., Soucek, K., Sova, P., Hofmanova, J., Kozubik, A. (2010), LA-12 Overcomes Confluence-dependent Resistance of HT-29 Colon Cancer Cells to Pt (II) Compounds, ANTICANCER RESEARCH 30, 1183-1188 [AIS=0.363, IF=1.428 VH]
• Konopka, R., Hyzdalova, M., Kubala, L., Pachernik, J. (2010), New Luminescence-Based Approach to Measurement of Luciferase Gene Expression Reporter Activity and Adenosine Triphosphate-Based Determination of Cell Viability, FOLIA BIOLOGICA 56, 66-71 [AIS=0.295, IF=0.924 V]

2009

• Cajanek, L., Ribeiro, D., Liste, I., Parish, CL., Bryja, V., Arenas, E. (2009), Wnt/beta-Catenin Signaling Blockade Promotes Neuronal Induction and Dopaminergic Differentiation in Embryonic Stem Cells, STEM CELLS 27, 2917-2927 [AIS=2.69, IF=7.75 H]
• Krejci, P., Prochazkova, J., Bryja, V., Kozubik, A., Wilcox, WR. (2009), Molecular Pathology of the Fibroblast Growth Factor Family, HUMAN MUTATION 30, 1245-1255 [AIS=2.585, IF=6.887 H]
• Bryja, V., Andersson, ER., Schambony, A., Esner, M., Bryjova, L., Biris, KK., Hall, AC., Kraft, B., Cajanek, L., Yamaguchi, TP., Buckingham, M., Arenas, E. (2009), The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo, MOLECULAR BIOLOGY OF THE CELL 20, 924-936 [AIS=3.27, IF=5.98 H]
• Takacova, M., Holotnakova, T., Vondracek, J., Machala, M., Pencikova, K., Gradin, K., Poellinger, L., Pastorek, J., Pastorekova, S., Kopacek, J. (2009), Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX, BIOCHEMICAL JOURNAL 419, 419-425 [AIS=1.787, IF=5.155 H]
• Simeckova, P., Vondracek, J., Andrysik, Z., Zatloukalova, J., Krcmar, P., Kozubik, A., Machala, M. (2009), The 2,2',4,4',5,5'-Hexachlorobiphenyl-Enhanced Degradation of Connexin 43 Involves Both Proteasomal and Lysosomal Activities, TOXICOLOGICAL SCIENCES 107, 9-18 [AIS=1.27, IF=4.81 H]
• Hofmanova, J., Vaculova, A., Koubkova, Z., Hyzd'alova, M., Kozubik, A. (2009), Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs, MOLECULAR NUTRITION & FOOD RESEARCH 53, S102-S113 [AIS=1.07, IF=4.36 VH]
• Lincova, E., Hampl, A., Pernicova, Z., Starsichova, A., Krcmar, P., Machala, M., Kozubik, A., Soucek, K. (2009), Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs, BIOCHEMICAL PHARMACOLOGY 78, 561-572 [AIS=1.166, IF=4.254 VH]
• Krejci, P., Prochazkova, J., Bryja, V., Jelinkova, P., Pejchalova, K., Kozubik, A., Thompson, LM., Wilcox, WR. (2009), Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes, CELLULAR SIGNALLING 21, 151-160 [AIS=1.667, IF=4.094 H]
• Vaculova, A., Hofmanova, J., Zatloukalova, J., Kozubik, A. (2009), Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines, EXPERIMENTAL CELL RESEARCH 315, 3259-3266 [AIS=1.475, IF=3.589 VH]
• Valovicova, Z., Marvanova, S., Meszarosova, M., Srancikova, A., Trilecova, L., Milcova, A., Libalova, H., Vondracek, J., Machala, M., Topinka, J., Gabelova, A. (2009), Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 665, 51-60 [AIS=1.17, IF=3.56 H]
• Vanhara, P., Lincova, E., Kozubik, A., Jurdic, P., Soucek, K., Smarda, J. (2009), Growth/differentiation factor-15 inhibits differentiation into osteoclasts-A novel factor involved in control of osteoclast differentiation, DIFFERENTIATION 78, 213-222 [AIS=1.248, IF=3.311 VH]
• Ondrouskova, E., Slovackova, J., Pelkova, V., Prochazkova, J., Soucek, K., Benes, P., Smarda, J. (2009), Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase, BIOLOGICAL CHEMISTRY 390, 49-58 [AIS=1.104, IF=2.732 H]
• Jendzelovsky, R., Mikes, J., Koval, J., Soucek, K., Prochazkova, J., Kello, M., Sackova, V., Hofmanova, J., Kozubik, A., Fedorocko, P. (2009), Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells, PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 8, 1716-1723 [AIS=0.81, IF=2.71 H]
• Prochazkova, J., Stixova, L., Soucek, K., Hofmanova, J., Kozubik, A. (2009), Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery, EUROPEAN JOURNAL OF HAEMATOLOGY 83, 35-47 [AIS=0.643, IF=2.345 VH]
• Castagna, R., Davis, PA., Vasu, VT., Soucek, K., Cross, CE., Greci, L., Valacchi, G. (2009), Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells, TOXICOLOGY IN VITRO 23, 365-370 [AIS=0.55, IF=2.06 H]
• Stixova, L., Prochazkova, J., Soucek, K., Hofmanova, J., Kozubik, A. (2009), 5-Lipoxygenase inhibitors potentiate 1 alpha,25-dihydroxyvitamin D-3-induced monocytic differentiation by activating p38 MAPK pathway, MOLECULAR AND CELLULAR BIOCHEMISTRY 330, 229-238 [AIS=0.6, IF=1.9 VH]
• Starsichova, A., Kubala, L., Lincova, E., Pernicova, Z., Kozubik, A., Soucek, K. (2009), Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-beta 1, BIOLOGICAL PROCEDURES ONLINE 11, 316-324 [AIS=0.617, IF=1.29 VH]
• Kunke, D., Bryja, V., Mygland, L., Arenas, E., Krauss, S. (2009), Inhibition of canonical Wnt signaling promotes gliogenesis in P0-NSCs, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 386, 628-633 [AIS=0.905, IF=2.548 H]
• Yang, DH., Yoon, JY., Lee, SH., Bryja, V., Andersson, ER., Arenas, E., Kwon, YG., Choi, KY. (2009), Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/beta-Catenin and Protein Kinase C alpha, CIRCULATION RESEARCH 104, 372-379 [AIS=3.903, IF=9.214 H]
• Salazar, L., Kashiwada, T., Krejci, P., Muchowski, P., Donoghue, D., Wilcox, WR., Thompson, LM. (2009), A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells, HUMAN MOLECULAR GENETICS 18, 1951-1961 [AIS=3.379, IF=7.386 H]
• Matsushita, T., Wilcox, WR., Chan, YY., Kawanami, A., Bukulmez, H., Balmes, G., Krejci, P., Mekikian, PB., Otani, K., Yamaura, I., Warman, ML., Givol, D., Murakami, S. (2009), FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway, HUMAN MOLECULAR GENETICS 18, 227-240 [AIS=3.379, IF=7.386 H]
• Chlebova, K., Bryja, V., Dvorak, P., Kozubik, A., Wilcox, WR., Krejci, P. (2009), High molecular weight FGF2: the biology of a nuclear growth factor, CELLULAR AND MOLECULAR LIFE SCIENCES 66, 225-235 [AIS=2.34, IF=6.09 H]
• Andersson, T., Sodersten, E., Duckworth, JK., Cascante, A., Fritz, N., Sacchetti, P., Cervenka, I., Bryja, V., Hermanson, O. (2009), CXXC5 Is a Novel BMP4-regulated Modulator of Wnt Signaling in Neural Stem Cells, JOURNAL OF BIOLOGICAL CHEMISTRY 284, 3672-3681 [AIS=2.222, IF=5.328 H]
• Simeckova, P., Vondracek, J., Prochazkova, J., Kozubik, A., Krcmar, P., Machala, M. (2009), 2,2 ',4,4 ',5,5 '-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells, TOXICOLOGY 260, 104-111 [AIS=0.8, IF=3.24 H]
• Vondracek, J., Krcmar, P., Prochazkova, J., Trilecova, L., Gavelova, M., Skalova, L., Szotakova, B., Buncek, M., Radilova, H., Kozubik, A., Machala, M. (2009), The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells, CHEMICO-BIOLOGICAL INTERACTIONS 180, 226-237 [AIS=0.745, IF=2.457 H]
• Maioli, E., Greci, L., Soucek, K., Hyzdalova, M., Pecorelli, A., Fortino, V., Valacchi, G. (2009), Rottlerin Inhibits ROS Formation and Prevents NF kappa B Activation in MCF-7 and HT-29 Cells, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY [AIS=0.787, IF=1.75 H]
• Krejcova, D., Prochazkova, J., Kubala, L., Pachernik, J. (2009), Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha, GENERAL PHYSIOLOGY AND BIOPHYSICS 28, 294-301 [AIS=0.209, IF=0.741 V]

2008

• Weiss, C., Faust, D., Schreck, I., Ruff, A., Farwerck, T., Melenberg, A., Schneider, S., Oesch-Bartlomowicz, B., Zatloukalova, J., Vondracek, J., Oesch, F., Dietrich, C. (2008), TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A, ONCOGENE 27, 2198-2207 [AIS=2.79, IF=7.13 H]
• Andersson, ER., Prakash, N., Cajanek, L., Minina, E., Bryja, V., Bryjova, L., Yamaguchi, TP., Hall, AC., Wurst, W., Arenas, E. (2008), Wnt5a Regulates Ventral Midbrain Morphogenesis and the Development of A9-A10 Dopaminergic Cells In Vivo, PLOS ONE 3 [AIS=1.92, IF=4.35 H]
• Upham, BL., Blaha, L., Babica, P., Park, JS., Sovadinova, I., Pudrith, C., Rummel, AM., Weis, LM., Sai, K., Tithof, PK., Guzvic, M., Vondracek, J., Machala, M., Trosko, JE. (2008), Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C, CANCER SCIENCE 99, 696-705 [AIS=1.216, IF=3.771 H]
• Marvanova, S., Vondracek, J., Pencikova, K., Trilecova, L., Krcmar, P., Topinka, J., Novakova, Z., Milcova, A., Machala, M. (2008), Toxic effects of methylated benz[a]anthracenes in liver cells, CHEMICAL RESEARCH IN TOXICOLOGY 21, 503-512 [AIS=0.963, IF=3.74 H]
• Kummer, V., Maskova, J., Zraly, Z., Neca, J., Simeckova, P., Vondracek, J., Machala, M. (2008), Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats, TOXICOLOGY LETTERS 180, 212-221 [AIS=0.83, IF=3.48 H]
• Machala, M., Svihalkova-Sindlerova, L., Pencikova, K., Krcmar, P., Topinka, J., Milcova, A., Novakova, Z., Kozubik, A., Vondracek, J. (2008), Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells, TOXICOLOGY 247, 93-101 [AIS=0.8, IF=3.24 VH]
• Umannova, L., Neca, J., Andrysik, Z., Vondracek, J., Upham, BL., Trosko, JE., Hofmanova, J., Kozubik, A., Machala, M. (2008), Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: A partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1/2 signalling, TOXICOLOGY 247, 55-60 [AIS=0.8, IF=3.24 VH]
• Hyzd'alova, M., Hofmanova, J., Pachernik, J., Vaculova, A., Kozubik, A. (2008), The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappa B activation, CYTOKINE 44, 33-43 [AIS=0.931, IF=3.123 VH]
• Bryja, V., Pachernik, J., Vondracek, J., Soucek, K., Cajanek, L., Horvath, V., Holubcova, Z., Dvorak, P., Hampl, A. (2008), Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin, CELL PROLIFERATION 41, 875-893 [AIS=0.828, IF=2.917 H]
• Torricelli, C., Fortino, V., Capurro, E., Valacchi, G., Pacini, A., Muscettola, M., Soucek, K., Maioli, E. (2008), Rottlerin inhibits the nuclear factor kappa B/Cyclin-D1 cascade in MCF-7 breast cancer cells, LIFE SCIENCES 82, 638-643 [AIS=0.691, IF=2.56 H]
• Ondrouskova, E., Soucek, K., Horvath, V., Smarda, J. (2008), Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis, LEUKEMIA RESEARCH 32, 599-609 [AIS=0.663, IF=2.358 H]
• Kleban, J., Mikes, J., Horvath, V., Sackova, V., Hofmanova, J., Kozubik, A., Fedorocko, P. (2008), Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 93, 108-118 [AIS=0.539, IF=1.871 H]
• Hofmanova, J., Vaculova, A., Hyzd'Alova, M., Kozubik, A. (2008), Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers, ONCOLOGY REPORTS 19, 567-573 [AIS=0.45, IF=1.59 VH]
• Bryja, V., Schambony, A., Cajanek, L., Dominguez, I., Arenas, E., Schulte, G. (2008), beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways, EMBO REPORTS 9, 1244-1250 [AIS=3.993, IF=6.907 H]
• Krejci, P., Salazar, L., Goodridge, HS., Kashiwada, TA., Schibler, MJ., Jelinkova, P., Thompson, LM., Wilcox, WR. (2008), STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes, JOURNAL OF CELL SCIENCE 121, 272-281 [AIS=3.246, IF=6.144 H]
• Topinka, J., Marvanova, S., Vondracek, J., Sevastyanova, O., Novakova, Z., Krcmar, P., Pencikova, K., Machala, M. (2008), DNA adducts formation and induction of apoptosis in rat liver epithelial 'stem-like' cells exposed to carcinogenic polycyclic aromatic hydrocarbons, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 638, 122-132 [AIS=1.171, IF=3.556 H]
• Umannova, L., Machala, M., Topinka, J., Novakova, Z., Milcova, A., Kozubik, A., Vondracek, J. (2008), Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P4501B1 expression, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 640, 162-169 [AIS=1.171, IF=3.556 VH]

2007

• Schulte, G., Bryja, V. (2007), The Frizzled family of unconventional G-protein-coupled receptors, TRENDS IN PHARMACOLOGICAL SCIENCES 28, 518-525 [AIS=3.33, IF=9.06 H]
• Zatloukalova, J., Svihalkova-Sindlerova, L., Kozubik, A., Krcmar, P., Machala, M., Vondracek, J. (2007), beta-naphthoflavone and 3 '-methoxy-4 '-nitroflavone exert ambiguous effects on Ah receptor-dependent cell proliferation and gene expression in rat liver 'stem-like' cells, BIOCHEMICAL PHARMACOLOGY 73, 1622-1634 [AIS=1.166, IF=4.254 VH]
• Navratilova, J., Horvath, V., Kozubik, A., Lojek, A., Lipsick, J., Smarda, J. (2007), p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts, DIFFERENTIATION 75, 592-604 [AIS=1.248, IF=3.311]
• Horvath, V., Soucek, K., Svihalkova-Sindlerova, L., Vondracek, J., Blanarova, O., Hofmanova, J., Sova, P., Kozubik, A. (2007), Different cell cycle modulation following treatment of human ovarian carcinoma cells with a new platinum(IV) complex vs cisplatin, INVESTIGATIONAL NEW DRUGS 25, 435-443 [AIS=0.727, IF=3.072 VH]
• Prochazka, L., Turanek, J., Tesarik, R., Knotigova, P., Polaskova, P., Andrysik, Z., Kozubik, A., Zak, F., Sova, P., Neuzil, J., Machala, M. (2007), Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 462, 54-61 [AIS=0.975, IF=3.046 H]
• Pejchalova, K., Krejci, P., Wilcox, WR. (2007), C-natriuretic peptide: An important regulator of cartilage, MOLECULAR GENETICS AND METABOLISM 92, 210-215 [AIS=0.9, IF=2.9 H]
• Mikes, J., Kleban, J., Sackova, V., Horvath, V., Jamborova, E., Vaculova, A., Kozubik, A., Hofmanova, J., Fedorocko, P. (2007), Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin, PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 6, 758-766 [AIS=0.81, IF=2.71 H]
• Vondracek, J., Svihalkova-Sindlerova, L., Pencikova, K., Marvanova, S., Krcmar, P., Ciganek, M., Neca, J., Trosko, JE., Upham, B., Kozubik, A., Machala, M. (2007), Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 26, 2308-2316 [AIS=0.721, IF=2.565 H]
• Vanhara, P., Bryja, V., Horvath, V., Kozubik, A., Hampl, A., Smarda, J. (2007), c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353, 92-97 [AIS=0.905, IF=2.548 H]
• Benes, P., Maceckova, V., Zatloukalova, J., Kovarova, L., Smardova, J., Smarda, J. (2007), Retinoic acid enhances differentiation of v-myb-transformed monoblasts induced by okadaic acid, LEUKEMIA RESEARCH 31, 1421-1431 [AIS=0.663, IF=2.358 H]
• Kleban, J., Mikes, J., Szilardiova, B., Koval, J., Sackova, V., Solar, P., Horvath, V., Hofmanova, J., Kozubik, A., Fedorocko, P. (2007), Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells, PHOTOCHEMISTRY AND PHOTOBIOLOGY 83, 1174-1185 [AIS=0.71, IF=2.25 H]
• Solar, P., Horvath, V., Kleban, J., Koval, J., Solarova, Z., Kozubik, A., Fedorocko, P. (2007), Hsp90 inhibitor Geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin, NEOPLASMA 54, 127-130 [AIS=0.275, IF=1.192 H]
• Pachernik, J., Horvath, V., Kubala, L., Dvorak, P., Kozubik, A., Hampl, A. (2007), Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells, FOLIA BIOLOGICA 53, 157-163 [AIS=0.295, IF=0.924]
• Umannova, L., Zatloukalova, J., Machala, M., Krcmar, P., Majkova, Z., Hennig, B., Kozubik, A., Vondracek, J. (2007), Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver "stem-like" cells, TOXICOLOGICAL SCIENCES 99, 79-89 [AIS=1.27, IF=4.814 VH]
• Andrysik, Z., Vondracek, J., Machala, M., Krcmar, P., Svihalkova-Sindlerova, L., Kranz, A., Weiss, C., Faust, D., Kozubik, A., Dietrich, C. (2007), The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 615, 87-97 [AIS=1.171, IF=3.556 VH]
• Svihalkova-Sindlerova, L., Machala, M., Pencikova, K., Marvanova, S., Neca, J., Topinka, J., Sevastyanova, O., Kozubik, A., Vondracek, J. (2007), Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells, TOXICOLOGY 232, 147-159 [AIS=0.796, IF=3.241 VH]
• Krejci, P., Pejchalova, K., Wilcox, WR. (2007), Simple, mammalian cell-based assay for identification of inhibitors of the Erk MAP kinase pathway, INVESTIGATIONAL NEW DRUGS 25, 391-395 [AIS=0.733, IF=3.072 H]
• Bartova, E., Pachernik, J., Kozubik, A., Kozubek, S. (2007), Differentiation-specific association of HP1 alpha and HP1 beta with chromocentres is correlated with clustering of TIF1 beta at these sites, JOURNAL OF HISTOCHEMISTRY AND CELL BIOLOGY 127, 375-388 [AIS=0.964, IF=3.021 V]
• Streitova, D., Weiterova, L., Hofer, M., Hola, J., Horvath, V., Kozubik, A., Znojil, V. (2007), Effect of adenosine on the growth of human T-lymphocyte leukemia cell line MOLT-4, CANCER INVESTIGATION 25, 419-426 [AIS=0.596, IF=2.105 V]

2006

• Stika, J., Vondracek, J., Hofmanova, J., Simek, V., Kozubik, A. (2006), MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis, CANCER LETTERS 237, 263-271 [AIS=1.005, IF=3.741 H]
• Horvath, V., Blanarova, O., Svihalkova-Sindlerova, L., Soucek, K., Hofmanova, J., Sova, P., Kroutil, A., Fedorocko, P., Kozubik, A. (2006), Platinum(IV) complex with adamantylamine overcomes intrinsic resistance to cisplatin in ovarian cancer cells, GYNECOLOGIC ONCOLOGY 102, 32-40 [AIS=0.814, IF=3.733 VH]
• Vondracek, J., Svihalkova-Sindlerova, L., Pencikova, K., Krcmar, P., Andrysik, Z., Chramostova, K., Marvanova, S., Valovicova, Z., Kozubik, A., Gabelova, A., Machala, M. (2006), 7H-Dibenzo[c,g]carbazole and 5,9-dimethyldibenzo[c,g]carbazole exert multiple toxic events contributing to tumor promotion in rat liver epithelial 'stem-like' cells, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 596, 43-56 [AIS=1.17, IF=3.56 H]
• Vaculova, A., Hofmanova, J., Soucek, K., Kozubik, A. (2006), Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells, FEBS LETTERS 580, 6565-6569 [AIS=1.299, IF=3.541 VH]
• Andrysik, Z., Machala, M., Chramostova, K., Hofmanova, J., Kozubik, A., Vodracek, J. (2006), Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis, TOXICOLOGY AND APPLIED PHARMACOLOGY 211, 198-208 [AIS=1.05, IF=3.36 VH]
• Vondracek, J., Soucek, K., Sheard, MA., Chramostova, K., Andrysik, Z., Hofmanova, J., Kozubik, A. (2006), Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization, LEUKEMIA RESEARCH 30, 81-89 [AIS=0.663, IF=2.358 VH]
• Kleban, J., Szilardiova, B., Mikes, J., Horvath, V., Sackova, V., Brezani, P., Hofmanova, J., Kozubik, A., Fedorocko, P. (2006), Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 84, 79-88 [AIS=0.539, IF=1.871 H]
• Hofer, M., Pospisil, M., Znojil, V., Hola, J., Vacek, A., Weiterova, L., Streitova, D., Kozubik, A. (2006), Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice, RADIATION RESEARCH 166, 556-560 [AIS=0.903, IF=2.948 V]
• Soucek, K., Pachernik, J., Kubala, L., Vondracek, J., Hofmanova, J., Kozubik, A. (2006), Transforming growth factor-beta 1 inhibits all-trans retinoic acid-induced apoptosis, LEUKEMIA RESEARCH 30, 607-623 [AIS=0.663, IF=2.358 VH]

2005

• Bryja, V., Cajanek, L., Pachernik, J., Hall, AC., Horvath, V., Dvorak, P., Hampl, A. (2005), Abnormal development of mouse embryoid bodies lacking p27(Kip1) cell cycle regulator, STEM CELLS 23, 965-974 [AIS=2.69, IF=7.75 H]
• Vondracek, J., Machala, M., Bryja, V., Chramostova, K., Krcmar, P., Dietrich, C., Hampl, A., Kozubik, A. (2005), Aryl hydrocarbon receptor-activating polychlorinated biphenyls and their hydroxylated metabolites induce cell proliferation in contact-inhibited rat liver epithelial cells, TOXICOLOGICAL SCIENCES 83, 53-63 [AIS=1.27, IF=4.81 VH]
• Pliskova, M., Vondracek, J., Vojtesek, B., Kozubik, A., Machala, M. (2005), Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events, TOXICOLOGICAL SCIENCES 83, 246-256 [AIS=1.27, IF=4.81 VH]
• Boon, EMJ., Kovarikova, M., Derksen, PWB., van der Neut, R. (2005), MET signalling in primary colon epithelial cells leads to increased transformation irrespective of aberrant Wnt signalling, BRITISH JOURNAL OF CANCER 92, 1078-1083 [AIS=1.467, IF=4.346 H]
• Kozubik, A., Horvath, V., Svihalkova-Sindlerova, L., Soucek, K., Hofmanova, J., Sova, P., Kroutil, A., Zak, F., Mistr, A., Turanek, J. (2005), High effectiveness of platinum(IV) complex with adamantylamine in overcoming resistance to cisplatin and suppressing proliferation of ovarian cancer cells in vitro, BIOCHEMICAL PHARMACOLOGY 69, 373-383 [AIS=1.166, IF=4.254 VH]
• Hofmanova, J., Vaculova, A., Kozubik, A. (2005), Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis, CANCER LETTERS 218, 33-41 [AIS=1.005, IF=3.741 VH]
• Vaculova, A., Hofmanova, J., Andera, L., Kozubik, A. (2005), TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death, CANCER LETTERS 229, 43-48 [AIS=1.005, IF=3.741 VH]
• Pliskova, M., Vondracek, J., Kren, V., Gazak, R., Sedmera, P., Walterova, D., Psotova, J., Simanek, V., Machala, M. (2005), Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation, TOXICOLOGY 215, 80-89 [AIS=0.8, IF=3.24 H]
• Pachernik, J., Bryja, V., Esner, M., Kubala, L., Dvorak, P., Hampl, A. (2005), Neural differentiation of pluripotent mouse embryonal carcinoma cells by retinoic acid: Inhibitory effect of serum, PHYSIOLOGICAL RESEARCH 54, 115-122 [AIS=0.41, IF=1.43]
• Hofmanova, J., Zadak, Z., Hyspler, R., Mikeska, J., Zdansky, P., Vaculova, A., Netikova, J., Kozubik, A. (2005), The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro, PHYSIOLOGICAL RESEARCH 54, 409-418 [AIS=0.41, IF=1.43 VH]
• Bartova, E., Pachernik, J., Harnicarova, A., Kovarik, A., Kovarikova, M., Hofmanova, J., Skalnikova, M., Kozubek, M., Kozubek, S. (2005), Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases, JOURNAL OF CELL SCIENCE 118, 5035-5046 [AIS=3.251, IF=6.144 V]
• Hofmanova, J., Vaculova, A., Lojek, A., Kozubik, A. (2005), Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells, EUROPEAN JOURNAL OF NUTRITION 44, 40-51 [AIS=0.827, IF=2.866 VH]

2004

• Bryja, V., Pachernik, J., Soucek, K., Horvath, V., Dvorak, P., Hampl, A. (2004), Increased apoptosis in differentiating p27-deficient mouse embryonic stem cells, CELLULAR AND MOLECULAR LIFE SCIENCES 61, 1384-1400 [AIS=2.34, IF=6.09 H]
• Zak, F., Turanek, J., Kroutil, A., Sova, P., Mistr, A., Poulova, A., Mikolin, P., Zak, Z., Kasna, A., Zaluska, D., Neca, J., Sindlerova, L., Kozubik, A. (2004), Platinum(IV) complex with adamantylamine as nonleaving amine group: Synthesis, characterization, and in vitro antitumor activity against a panel of cisplatin-resistant cancer cell lines, JOURNAL OF MEDICINAL CHEMISTRY 47, 761-763 [AIS=1.285, IF=4.802 H]
• Machala, M., Blaha, L., Lehmler, HJ., Pliskova, M., Majkova, Z., Kapplova, P., Sovadinova, I., Vondracek, J., Malmberg, T., Robertson, LW. (2004), Toxicity of hydroxylated and quinoid PCB metabolites: Inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells, CHEMICAL RESEARCH IN TOXICOLOGY 17, 340-347 [AIS=0.963, IF=3.74 H]
• Vaculova, A., Hofmanova, J., Soucek, K., Andera, L., Kozubik, A. (2004), Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis, FEBS LETTERS 577, 309-313 [AIS=1.299, IF=3.541 VH]
• Chramostova, K., Vondracek, J., Sindlerova, L., Vojtesek, B., Kozubik, A., Machala, M. (2004), Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells, TOXICOLOGY AND APPLIED PHARMACOLOGY 196, 136-148 [AIS=1.05, IF=3.36 VH]
• Kovarikova, M., Hofmanova, J., Soucek, K., Kozubik, A. (2004), The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status, DIFFERENTIATION 72, 23-31 [AIS=1.248, IF=3.311 VH]
• Vondracek, J., Chramostova, K., Pliskova, M., Blaha, L., Brack, W., Kozubik, A., Machala, M. (2004), Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 23, 2214-2220 [AIS=0.721, IF=2.565 H]
• Turanek, J., Kasna, A., Zaluska, D., Neca, J., Kvardova, V., Knotigova, P., Horvath, V., Sindlerova, L., Kozubik, A., Sova, P., Kroutil, A., Zak, FE., Mistr, A. (2004), New platinum(IV) complex with adamantylamine ligand as a promising anti-cancer drug: comparison of in vitro cytotoxic potential towards A2780/cisR cisplatin-resistant cell line within homologous series of platinum(IV) complexes, ANTI-CANCER DRUGS 15, 537-543 [AIS=0.576, IF=2.23 H]
• Vacek, J., Andrysik, Z., Trnkova, L., Kizek, R. (2004), Determination of azidothymidine - an antiproliferative and virostatic drug by square-wave voltammetry, ELECTROANALYSIS 16, 224-230 [AIS=0.615, IF=2.63 V]
• Hoferova, Z., Soucek, K., Hofmanova, J., Hofer, M., Chramostova, K., Fedorocko, P., Kozubik, A. (2004), In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase, CANCER INVESTIGATION 22, 234-247 [AIS=0.596, IF=2.105 V]

2003

• Zahradnickova, E., Soucek, K., Sevcikova, S., Smardova, J., Smarda, K. (2003), c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts, CELLULAR AND MOLECULAR LIFE SCIENCES 60, 2736-2748 [AIS=2.34, IF=6.09 H]
• Machala, M., Blaha, L., Vondracek, J., Trosko, JE., Scott, J., Upham, BL. (2003), Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: Inhibitory potencies and screening for potential mode(s) of action, TOXICOLOGICAL SCIENCES 76, 102-111 [AIS=1.27, IF=4.81 H]
• Bryja, V., Sedlacek, J., Zahradnickova, E., Sevcikova, S., Pachernik, J., Soucek, K., Hofmanova, J., Kozubik, A., Smarda, J. (2003), Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2, PROSTAGLANDINS & OTHER LIPID MEDIATORS 72, 131-145 [AIS=0.72, IF=2.56 H]
• Hofer, M., Hoferova, Z., Pospisil, M., Znojil, V., Chramostova, K. (2003), Effects of adenosine on the growth of murine G : 5 : 113 fibrosarcoma cells in vitro, FOLIA BIOLOGICA 49, 207-210 [AIS=0.295, IF=0.924 V]
• Hoferova, Z., Hofer, M., Pospisil, M., Znojil, V., Chramostova, K. (2003), Effects of synthetic adenosine receptor agonists on growth characteristics of G : 5 : 113 fibrosarcoma cells in vitro, DRUG DEVELOPMENT RESEARCH 60, 303-311 [AIS=0.275, IF=0.67 V]
• Nemajerova, A., Smarda, J., Jurdic, P., Kubala, L., Soucek, K., Smardova, J. (2003), Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells, JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH 12, 225-235 [AIS=0, IF=0]
• Bartova, E., Jirsova, P., Fojtova, M., Soucek, K., Kozubek, S. (2003), Chromosomal territory segmentation in apoptotic cells, CELLULAR AND MOLECULAR LIFE SCIENCES 60, 979-990 [AIS=2.34, IF=6.09 V]
• Hoferova, Z., Vacek, A., Hofer, M., Mackova, NO., Soucek, K., Egyed, A., Fedorocko, P. (2003), Tumor-host interactions accompanying the growth of the G : 5 : 113 fibrosarcoma in the mouse: Possibilities for a new therapeutic approach?, CANCER INVESTIGATION 21, 227-236 [AIS=0.596, IF=2.105 V]
• Bryja, V., Pachernik, H., Kubala, L., Hampl, A., Dvorak, P. (2003), The reverse tetracycline-controlled transactivator rtTA2(S)-S2 is toxic in mouse embryonic stem cells, REPRODUCTION NUTRITION DEVELOPMENT 43, 477-486 [AIS=0.403, IF=1.461]
• Fajkus, J., Borsky, M., Kunicka, Z., Kovarikova, M., Dvorakova, D., Hofmanova, J., Kozubik, A. (2003), Changes in telomerase activity, expression and splicing in response to differentiation of normal and carcinoma colon cells, ANTICANCER RESEARCH 23, 1605-1612 [AIS=0.361, IF=1.428 V]
• Hoferova, Z., Fedorocko, P., Hofer, M., Hofmanova, J., Kozubik, A., Eliasova, V. (2003), Lipoxygenase inhibitors suppress proliferation of G5 : 113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo, NEOPLASMA 50, 102-109 [AIS=0.275, IF=1.192 V]

2002

• Sevcikova, S., Soucek, K., Kubala, L., Bryja, V., Smarda, J. (2002), Differential effects of v-Jun and C-Jun proteins on v-myb-transformed monoblasts, CELLULAR AND MOLECULAR LIFE SCIENCES 59, 1690-1705 [AIS=2.34, IF=6.09]
• Blaha, L., Kapplova, P., Vondracek, J., Upham, B., Machala, M. (2002), Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons, TOXICOLOGICAL SCIENCES 65, 43-51 [AIS=1.27, IF=4.81 H]
• Vondracek, J., Kozubik, A., Machala, M. (2002), Modulation of estrogen receptor-dependent reporter construct activation and G(0)/G(1)-S-phase transition by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells, TOXICOLOGICAL SCIENCES 70, 193-201 [AIS=1.27, IF=4.81 VH]
• Solar, P., Cavarga, I., Hofmanova, J., Cekanova-Figurova, M., Miskovsky, P., Brezani, P., Hrckova, G., Kozubik, A., Fedorocko, P. (2002), Effect of acetazolamide on hypericin photocytotoxicity, PLANTA MEDICA 68, 658-660 [AIS=0.49, IF=2.04 H]
• Pachernik, J., Hampl, A., Soucek, K., Kovarikova, M., Andrysik, Z., Hofmanova, O., Kozubik, A. (2002), Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes, ARCHIVES OF DERMATOLOGICAL RESEARCH 293, 626-633 [AIS=0.503, IF=1.844 VH]
• Vaculova, A., Hofmanova, J., Soucek, K., Kovarikova, M., Kozubik, A. (2002), Tumor necrosis factor-alpha induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells, ANTICANCER RESEARCH 22, 1635-1639 [AIS=0.361, IF=1.428 VH]
• Hofmanova, J., Soucek, K., Pachernik, J., Kovarikova, M., Hoferova, Z., Minksova, K., Netikova, J., Kozubik, A. (2002), Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle, NEOPLASMA 49, 362-367 [AIS=0.275, IF=1.192 VH]
• Pachernik, J., Janik, R., Hofmanova, J., Bryja, V., Kozubik, A. (2002), Conditions for gene transfection into the HL-60 human leukaemia cell line by electroporation, FOLIA BIOLOGICA 48, 154-156 [AIS=0.295, IF=0.924 VH]
• Kubala, L., Ciz, M., Vondracek, J., Cerny, J., Nemec, P., Studenik, P., Cizova, H., Lojek, A. (2002), Perioperative and postoperative course of cytokines and the metabolic activity of neutrophils in human cardiac operations and heart transplantation, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 124, 1122-1129 [AIS=1.248, IF=3.063 V]
• Hoferova, Z., Fedorocko, P., Hofmanova, J., Hofer, M., Znojil, V., Minksova, K., Soucek, K., Egyed, A., Kozubik, A. (2002), The effect of nonsteroidal anti-inflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma, CANCER INVESTIGATION 20, 490-498 [AIS=0.596, IF=2.105 VH]

2001

• Dvorakova, D., Krejci, P., Mayer, J., Fajkus, J., Hampl, A., Dvorak, P. (2001), Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells, BRITISH JOURNAL OF HAEMATOLOGY 113, 832-835 [AIS=1.495, IF=4.597]
• Vondracek, J., Stika, J., Soucek, K., Minksova, K., Blaha, L., Hofmanova, J., Kozubik, A. (2001), Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells, EUROPEAN JOURNAL OF PHARMACOLOGY 424, 1-11 [AIS=0.688, IF=2.585 VH]
• Machala, M., Ciganek, M., Blaha, L., Minksova, K., Vondrack, J. (2001), Aryl hydrocarbon receptor-mediated and estrogenic activities of oxygenated polycyclic aromatic hydrocarbons and azaarenes originally identified in extracts of river sediments, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 20, 2736-2743 [AIS=0.721, IF=2.565 H]
• Vondracek, J., Machala, M., Minksova, K., Blaha, L., Murk, AJ., Kozubik, A., Hofmanova, J., Hilscherova, K., Ulrich, R., Ciganek, M., Neca, J., Svrckova, D., Holoubek, I. (2001), Monitoring river sediments contaminated predominantly with polyaromatic hydrocarbons by chemical and in vitro bioassay techniques, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 20, 1499-1506 [AIS=0.721, IF=2.565 H]
• Machala, M., Vondracek, J., Blaha, L., Ciganek, M., Neca, J. (2001), Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 497, 49-62 [AIS=0.6, IF=2.55 H]
• Pachernik, J., Soucek, K., Hampl, A., Hofmanova, J., Kozubik, A. (2001), Transforming growth factor-beta 1 induces junB mRNA accumulation, G1-phase arrest, and pRb dephosphorylation in human leukemia HL-60 cells, FOLIA BIOLOGICA 47, 32-35 [AIS=0.295, IF=0.924 VH]
• Kubinova, R., Machala, M., Minksova, K., Neca, J., Suchy, V. (2001), Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes, PHARMAZIE 56, 242-243 [AIS=0.167, IF=0.812 H]
• Vondracek, J., Sheard, MA., Krejci, P., Minksova, K., Hofmanova, J., Kozubik, A. (2001), Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells, JOURNAL OF LEUKOCYTE BIOLOGY 69, 794-802 [AIS=1.672, IF=4.403 VH]
• Kubala, L., Ciz, M., Vondracek, J., Cizova, H., Cerny, J., Nemec, P., Studenik, P., Duskova, M., Lojek, A. (2001), Peri- and post-operative course of cytokines and the metabolic activity of neutrophils in human liver transplantation, CYTOKINE 16, 97-101 [AIS=0.931, IF=3.123]

2000

• Kovarikova, M., Pachernik, J., Hofmanova, J., Zadak, Z., Kozubik, A. (2000), TNF-alpha modulates the differentiation induced by butyrate in the HT-29 human colon adenocarcinoma cell line, EUROPEAN JOURNAL OF CANCER 36, 1844-1852 [AIS=1.364, IF=4.121 VH]
• Hampl, A., Pachernik, J., Dvorak, P. (2000), Levels and interactions of p27, cyclin D3, and CDK4 during the formation and maintenance of the corpus luteum in mice, BIOLOGY OF REPRODUCTION 62, 1393-1401 [AIS=1.039, IF=3.3 H]
• Vodicka, P., Sevcikova, S., Smardova, J., Soucek, K., Smarda, J. (2000), The effects of RAR alpha and RXR alpha proteins on growth, viability, and differentiation of v-MYB-transformed monoblasts, BLOOD CELLS MOLECULES AND DISEASES 26, 395-406 [AIS=0.895, IF=2.901 H]
• Hofmanova, J., Soucek, K., Dusek, L., Netikova, J., Kozubik, A. (2000), Inhibition of cytochrome P-450 modulates all-trans-retinoic acid-induced differentiation and apoptosis of HL-60 cells, CANCER DETECTION AND PREVENTION 24, 325-342 [AIS=0.673, IF=2.056 VH]
• Hofmanova, J., Machala, M., Kozubik, A. (2000), Epigenetic mechanisms of the carcinogenic effects of xenobiotics and in vitro methods of their detection, FOLIA BIOLOGICA 46, 165-173 [AIS=0.295, IF=0.924 VH]