Diffractive-optics-based sensor as a tool for detection of biocompatibility of titanium and titanium-doped hydrocarbon samples

Published: APPLIED OPTICS 49, 5583-5591 Authors: Silvennoinen, R., Hason, S., Vetterl, V., Penttinen, N., Silvennoinen, M., Myller, K., Cernochova, P., Bartakova, S., Prachar, P., Cvrcek, L. Year: 2010


Adsorption of the elongated human plasma fibrinogen (HPF) and globular human serum albumin molecules on a titanium-based surface is monitored by analyzing permittivity and optical roughness of protein-modified surfaces by using a diffractive optical element (DOE)-based sensor and variable angle spectro-ellipsometry (VASE). Both DOE and VASE confirmed that fibrinogen forms a thicker and more packed surface adlayer compared to a more porous and weakly adsorbed albumin adlayer. A linear relation of the permittivity (e') and dielectric loss (e '') was found for some of the dry titanium-doped hydrocarbon (TDHC) surfaces with excellent HPF adsorption ability. We discuss some aspects of TDHC's aging and its possible effects on fibrinogen adsorption. (C) 2010 Optical Society of America