Peroral IMUNOR (R), a low-molecular-weight immunomodulator prepared from disintegrated and ultrafiltered leukocytes, enhances recovery from myelosuppression induced by cisplatin or 5-fluorouracil

Časopis: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 28, 1-11
Autoři: Hofer, M., Vacek, A., Hola, J., Weiterova, L., Streitova, D.
Rok: 2006

Abstrakt

A single dose of IMUNOR (R), a low-molecular-weight immunodulator prepared from disintegrated and ultrafiltered pig leukocytes, was found to enhance recovery of murine pool of hemopoietic progenitor cells for granulocytes and macrophages damaged by a single injection of cytotoxic drugs 5-fluorouracil or cisplatin. The best results were obtained after the treatment with IMUNOR (R) on days 3 or 4 after the injection of 5-fluorouracil or cisplatin. These results together with previous findings obtained in our laboratory suggest that IMUNOR (R) has the potential to become a part of treatment schemes in oncological practice aimed at alleviation of myelosuppression evoked by cytotoxic anti-tumor therapy.