Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Published: CARCINOGENESIS 36, S2-S18 Authors: Nahta, R., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Andrade-Vieira, R., Bay, S., Brown, DG., Calaf, GM., Castellino, RC., Cohen-Solal, KA., Colacci, A., Cruickshanks, N., Dent, P., Di Fiore, R., Forte, S., Goldberg, GS., Hamid, RA., Krishnan, H., Laird, DW., Lasfar, A., Marignani, PA., Memeo, L., Mondello, C., Naus, CC., Ponce-Cusi, R., Raju, J., Roy, D., Roy, R., Ryan, EP., Salem, HK., Scovassi, AI., Singh, N., Vaccari, M., Vento, R., Vondracek, J., Wade, M., Woodrick, J., Bisson, WH. Year: 2015

Abstract

There is an urgent need to understand the molecular mechanisms by which sustained exposure to low-dose environmental chemical mixtures promotes carcinogenesis. This Halifax Project review specifically examines the effects of environmental chemicals on the cancer hallmark of evading growth suppression.As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.