Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA

Publikace: PHYSICAL CHEMISTRY CHEMICAL PHYSICS 13, 10869-10871 Autoři: Mladek, A., Sponer, J., Sumpter, BG., Fuentes-Cabrera, M., Sponer, JE. Rok: 2011


Quantum chemical calculations reveal that neither steric hindrance nor less polar solvent medium is able to reduce the otherwise high hydrolysis rate of arsenate-esters. These results question the stability of As-DNA not only in aqueous but also in non-aqueous environments.