Modulation of neutrophil oxidative burst via histamine receptors

Publikace: BRITISH JOURNAL OF PHARMACOLOGY 170, 17-22 Autoři: Ciz, M., Lojek, A. Rok: 2013


Histamine has the ability to influence the activity of immune cells including neutrophils and plays a pivotal role in inflammatory processes, which are a complex network of cellular and humoral events. One of the main functions manifested by activated neutrophils is oxidative burst, which is linked to the production of reactive oxygen species; therefore, the effects of histamine receptor agonists and antagonists on the oxidative burst of neutrophils is reviewed. A role for the well-characterized histamine H-1 and H-2 receptors in this process is discussed and compared to that of the recently discovered H-4 receptor.