Adamantylamide dipeptide stimulates hematopoiesis and increases survival in irradiated mice

Publikace: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY 22, 91-97 Autoři: Hofer, M., Vacek, A., Masek, K., Juchelkova, L., Pipalova, I. Rok: 2000


It has been demonstrated that the synthetic immunostimulatory compound, adamantylamide dipeptide (AdDP) produces hematopoiesis-stimulating effects in mice exposed to sublethal doses of ionizing radiation and increases survival in experimental animals irradiated with a lethal dose. These findings might suggest contingent extension of clinical indications for the administration of AdDP for the conditions of hematopoietic suppression, especially in oncology. (C) 2000 International Society for Immunopharmacology. Published by Elsevier Science Ltd. All rights reserved.